| Full name: cystatin B | Alias Symbol: CST6|PME | ||
| Type: protein-coding gene | Cytoband: 21q22.3 | ||
| Entrez ID: 1476 | HGNC ID: HGNC:2482 | Ensembl Gene: ENSG00000160213 | OMIM ID: 601145 |
| Drug and gene relationship at DGIdb | |||
Expression of CSTB:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CSTB | 1476 | 201201_at | -0.6311 | 0.1787 | |
| GSE20347 | CSTB | 1476 | 201201_at | -1.4565 | 0.0000 | |
| GSE23400 | CSTB | 1476 | 201201_at | -1.4018 | 0.0000 | |
| GSE26886 | CSTB | 1476 | 201201_at | -2.1504 | 0.0000 | |
| GSE29001 | CSTB | 1476 | 201201_at | -1.1779 | 0.0001 | |
| GSE38129 | CSTB | 1476 | 201201_at | -0.8258 | 0.0225 | |
| GSE45670 | CSTB | 1476 | 201201_at | -0.4285 | 0.0069 | |
| GSE53622 | CSTB | 1476 | 57322 | -2.5577 | 0.0000 | |
| GSE53624 | CSTB | 1476 | 57322 | -2.9675 | 0.0000 | |
| GSE63941 | CSTB | 1476 | 201201_at | 0.2563 | 0.6031 | |
| GSE77861 | CSTB | 1476 | 201201_at | -0.8999 | 0.0134 | |
| GSE97050 | CSTB | 1476 | A_23_P154894 | -1.6899 | 0.1453 | |
| SRP007169 | CSTB | 1476 | RNAseq | -5.8424 | 0.0000 | |
| SRP008496 | CSTB | 1476 | RNAseq | -5.5528 | 0.0000 | |
| SRP064894 | CSTB | 1476 | RNAseq | -4.2711 | 0.0000 | |
| SRP133303 | CSTB | 1476 | RNAseq | -4.7317 | 0.0000 | |
| SRP159526 | CSTB | 1476 | RNAseq | -4.7993 | 0.0000 | |
| SRP193095 | CSTB | 1476 | RNAseq | -4.0580 | 0.0000 | |
| SRP219564 | CSTB | 1476 | RNAseq | -4.1901 | 0.0000 | |
| TCGA | CSTB | 1476 | RNAseq | 0.2653 | 0.0337 |
Upregulated datasets: 0; Downregulated datasets: 13.
Survival by CSTB expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CSTB:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CSTB | 1476 | 2 | 8 | 20 | |
| GSE20123 | CSTB | 1476 | 2 | 8 | 20 | |
| GSE43470 | CSTB | 1476 | 0 | 13 | 30 | |
| GSE46452 | CSTB | 1476 | 1 | 21 | 37 | |
| GSE47630 | CSTB | 1476 | 6 | 17 | 17 | |
| GSE54993 | CSTB | 1476 | 8 | 1 | 61 | |
| GSE54994 | CSTB | 1476 | 4 | 8 | 41 | |
| GSE60625 | CSTB | 1476 | 0 | 0 | 11 | |
| GSE74703 | CSTB | 1476 | 0 | 10 | 26 | |
| GSE74704 | CSTB | 1476 | 1 | 4 | 15 | |
| TCGA | CSTB | 1476 | 7 | 40 | 49 |
Total number of gains: 31; Total number of losses: 130; Total Number of normals: 327.
Somatic mutations of CSTB:
Generating mutation plots.
Highly correlated genes for CSTB:
Showing top 20/1749 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CSTB | PPL | 0.903335 | 12 | 0 | 12 |
| CSTB | CNFN | 0.894919 | 8 | 0 | 8 |
| CSTB | VSIG10L | 0.894019 | 7 | 0 | 7 |
| CSTB | TMPRSS11E | 0.882891 | 11 | 0 | 11 |
| CSTB | IL1RN | 0.880436 | 12 | 0 | 12 |
| CSTB | CLIC3 | 0.880038 | 10 | 0 | 10 |
| CSTB | SLURP1 | 0.879653 | 12 | 0 | 12 |
| CSTB | CRCT1 | 0.877651 | 12 | 0 | 12 |
| CSTB | NCCRP1 | 0.877036 | 4 | 0 | 4 |
| CSTB | S100A16 | 0.873459 | 8 | 0 | 8 |
| CSTB | ANXA1 | 0.873457 | 12 | 0 | 12 |
| CSTB | SCEL | 0.865738 | 13 | 0 | 12 |
| CSTB | MALL | 0.865569 | 12 | 0 | 12 |
| CSTB | SPINK7 | 0.865064 | 8 | 0 | 8 |
| CSTB | RAET1E | 0.861655 | 7 | 0 | 7 |
| CSTB | TGM3 | 0.860194 | 12 | 0 | 12 |
| CSTB | EMP1 | 0.859954 | 12 | 0 | 11 |
| CSTB | C5orf66-AS1 | 0.85962 | 6 | 0 | 6 |
| CSTB | S100A14 | 0.859596 | 12 | 0 | 12 |
| CSTB | SERPINB1 | 0.858629 | 12 | 0 | 12 |
For details and further investigation, click here
