| Full name: potassium voltage-gated channel subfamily H member 6 | Alias Symbol: Kv11.2|erg2|HERG2 | ||
| Type: protein-coding gene | Cytoband: 17q23.3 | ||
| Entrez ID: 81033 | HGNC ID: HGNC:18862 | Ensembl Gene: ENSG00000173826 | OMIM ID: 608168 |
| Drug and gene relationship at DGIdb | |||
Expression of KCNH6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KCNH6 | 81033 | 221023_s_at | -0.0417 | 0.8709 | |
| GSE20347 | KCNH6 | 81033 | 221023_s_at | 0.0002 | 0.9982 | |
| GSE23400 | KCNH6 | 81033 | 221023_s_at | -0.1103 | 0.0014 | |
| GSE26886 | KCNH6 | 81033 | 221023_s_at | 0.0108 | 0.9448 | |
| GSE29001 | KCNH6 | 81033 | 221023_s_at | -0.0628 | 0.7565 | |
| GSE38129 | KCNH6 | 81033 | 221023_s_at | -0.0764 | 0.3006 | |
| GSE45670 | KCNH6 | 81033 | 221023_s_at | 0.0537 | 0.5644 | |
| GSE53622 | KCNH6 | 81033 | 52680 | 0.1257 | 0.4541 | |
| GSE53624 | KCNH6 | 81033 | 52680 | 0.4728 | 0.0002 | |
| GSE63941 | KCNH6 | 81033 | 221023_s_at | 0.0698 | 0.6245 | |
| GSE77861 | KCNH6 | 81033 | 221023_s_at | 0.0397 | 0.7328 | |
| GSE97050 | KCNH6 | 81033 | A_23_P170541 | -0.0908 | 0.7660 | |
| SRP133303 | KCNH6 | 81033 | RNAseq | -0.0452 | 0.8814 | |
| TCGA | KCNH6 | 81033 | RNAseq | -3.7841 | 0.0012 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by KCNH6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KCNH6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KCNH6 | 81033 | 3 | 1 | 26 | |
| GSE20123 | KCNH6 | 81033 | 3 | 1 | 26 | |
| GSE43470 | KCNH6 | 81033 | 4 | 0 | 39 | |
| GSE46452 | KCNH6 | 81033 | 31 | 0 | 28 | |
| GSE47630 | KCNH6 | 81033 | 7 | 1 | 32 | |
| GSE54993 | KCNH6 | 81033 | 2 | 5 | 63 | |
| GSE54994 | KCNH6 | 81033 | 9 | 5 | 39 | |
| GSE60625 | KCNH6 | 81033 | 4 | 0 | 7 | |
| GSE74703 | KCNH6 | 81033 | 4 | 0 | 32 | |
| GSE74704 | KCNH6 | 81033 | 3 | 1 | 16 | |
| TCGA | KCNH6 | 81033 | 31 | 8 | 57 |
Total number of gains: 101; Total number of losses: 22; Total Number of normals: 365.
Somatic mutations of KCNH6:
Generating mutation plots.
Highly correlated genes for KCNH6:
Showing top 20/457 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KCNH6 | BIRC7 | 0.71058 | 5 | 0 | 5 |
| KCNH6 | FBXL18 | 0.708475 | 3 | 0 | 3 |
| KCNH6 | MLNR | 0.702418 | 3 | 0 | 3 |
| KCNH6 | UGT2B17 | 0.691921 | 3 | 0 | 3 |
| KCNH6 | USP29 | 0.682327 | 4 | 0 | 3 |
| KCNH6 | TAS2R8 | 0.673514 | 3 | 0 | 3 |
| KCNH6 | OR6A2 | 0.672139 | 4 | 0 | 3 |
| KCNH6 | LILRA3 | 0.663986 | 3 | 0 | 3 |
| KCNH6 | RNF17 | 0.663888 | 3 | 0 | 3 |
| KCNH6 | CITED1 | 0.661478 | 4 | 0 | 4 |
| KCNH6 | LINC00950 | 0.660862 | 4 | 0 | 3 |
| KCNH6 | OVGP1 | 0.657262 | 5 | 0 | 5 |
| KCNH6 | APOA4 | 0.652457 | 3 | 0 | 3 |
| KCNH6 | ARHGEF38 | 0.646467 | 5 | 0 | 4 |
| KCNH6 | ZMAT4 | 0.645714 | 5 | 0 | 5 |
| KCNH6 | LINC00574 | 0.645164 | 4 | 0 | 3 |
| KCNH6 | LAMC3 | 0.641285 | 5 | 0 | 5 |
| KCNH6 | ARHGEF1 | 0.636885 | 3 | 0 | 3 |
| KCNH6 | RUNX2 | 0.636228 | 4 | 0 | 3 |
| KCNH6 | ALDOB | 0.636067 | 5 | 0 | 4 |
For details and further investigation, click here
