| Full name: homeostatic iron regulator | Alias Symbol: HLA-H | ||
| Type: protein-coding gene | Cytoband: 6p22.2 | ||
| Entrez ID: 3077 | HGNC ID: HGNC:4886 | Ensembl Gene: ENSG00000010704 | OMIM ID: 613609 |
| Drug and gene relationship at DGIdb | |||
Expression of HFE:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HFE | 3077 | 206087_x_at | 0.3292 | 0.4909 | |
| GSE20347 | HFE | 3077 | 211332_x_at | -0.0779 | 0.4372 | |
| GSE23400 | HFE | 3077 | 210864_x_at | -0.2216 | 0.0000 | |
| GSE26886 | HFE | 3077 | 211332_x_at | 0.0497 | 0.7474 | |
| GSE29001 | HFE | 3077 | 206087_x_at | 0.4916 | 0.0746 | |
| GSE38129 | HFE | 3077 | 206087_x_at | 0.1216 | 0.2665 | |
| GSE45670 | HFE | 3077 | 206087_x_at | 0.0982 | 0.6309 | |
| GSE53622 | HFE | 3077 | 60092 | 0.0808 | 0.5143 | |
| GSE53624 | HFE | 3077 | 60092 | 0.3796 | 0.0005 | |
| GSE63941 | HFE | 3077 | 206087_x_at | -0.0276 | 0.9624 | |
| GSE77861 | HFE | 3077 | 211332_x_at | -0.2728 | 0.0241 | |
| GSE97050 | HFE | 3077 | A_24_P111996 | 0.0404 | 0.8514 | |
| SRP007169 | HFE | 3077 | RNAseq | 0.3846 | 0.5223 | |
| SRP008496 | HFE | 3077 | RNAseq | 0.4650 | 0.3529 | |
| SRP064894 | HFE | 3077 | RNAseq | 0.2996 | 0.1771 | |
| SRP133303 | HFE | 3077 | RNAseq | 0.2601 | 0.1409 | |
| SRP159526 | HFE | 3077 | RNAseq | 0.5234 | 0.2049 | |
| SRP193095 | HFE | 3077 | RNAseq | 0.3286 | 0.0396 | |
| SRP219564 | HFE | 3077 | RNAseq | 0.0390 | 0.9463 | |
| TCGA | HFE | 3077 | RNAseq | 0.0337 | 0.7110 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by HFE expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HFE:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HFE | 3077 | 4 | 2 | 24 | |
| GSE20123 | HFE | 3077 | 4 | 2 | 24 | |
| GSE43470 | HFE | 3077 | 5 | 0 | 38 | |
| GSE46452 | HFE | 3077 | 1 | 9 | 49 | |
| GSE47630 | HFE | 3077 | 8 | 5 | 27 | |
| GSE54993 | HFE | 3077 | 1 | 1 | 68 | |
| GSE54994 | HFE | 3077 | 10 | 4 | 39 | |
| GSE60625 | HFE | 3077 | 0 | 1 | 10 | |
| GSE74703 | HFE | 3077 | 5 | 0 | 31 | |
| GSE74704 | HFE | 3077 | 0 | 1 | 19 | |
| TCGA | HFE | 3077 | 15 | 20 | 61 |
Total number of gains: 53; Total number of losses: 45; Total Number of normals: 390.
Somatic mutations of HFE:
Generating mutation plots.
Highly correlated genes for HFE:
Showing top 20/230 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HFE | KCNQ3 | 0.778257 | 3 | 0 | 3 |
| HFE | TNFSF4 | 0.731884 | 3 | 0 | 3 |
| HFE | GSK3A | 0.728952 | 3 | 0 | 3 |
| HFE | PPP5C | 0.720134 | 3 | 0 | 3 |
| HFE | NEK11 | 0.710879 | 3 | 0 | 3 |
| HFE | IL18BP | 0.701367 | 4 | 0 | 3 |
| HFE | MBLAC2 | 0.699971 | 3 | 0 | 3 |
| HFE | CISH | 0.697837 | 4 | 0 | 4 |
| HFE | COMMD5 | 0.696357 | 3 | 0 | 3 |
| HFE | CTSS | 0.693422 | 3 | 0 | 3 |
| HFE | CDON | 0.692859 | 3 | 0 | 3 |
| HFE | KLHL20 | 0.690835 | 3 | 0 | 3 |
| HFE | SLC25A27 | 0.690288 | 3 | 0 | 3 |
| HFE | FCHO1 | 0.688333 | 3 | 0 | 3 |
| HFE | C8orf37 | 0.686954 | 3 | 0 | 3 |
| HFE | ZNF654 | 0.685989 | 3 | 0 | 3 |
| HFE | ADAMTSL5 | 0.685832 | 3 | 0 | 3 |
| HFE | KCNJ6 | 0.682357 | 3 | 0 | 3 |
| HFE | NCAM1 | 0.682268 | 3 | 0 | 3 |
| HFE | THRB | 0.674354 | 4 | 0 | 4 |
For details and further investigation, click here
