| Full name: potassium inwardly rectifying channel subfamily J member 8 | Alias Symbol: Kir6.1 | ||
| Type: protein-coding gene | Cytoband: 12p12.1 | ||
| Entrez ID: 3764 | HGNC ID: HGNC:6269 | Ensembl Gene: ENSG00000121361 | OMIM ID: 600935 |
| Drug and gene relationship at DGIdb | |||
KCNJ8 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04022 | cGMP-PKG signaling pathway |
Expression of KCNJ8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KCNJ8 | 3764 | 205303_at | 0.1035 | 0.8841 | |
| GSE20347 | KCNJ8 | 3764 | 205303_at | 0.1324 | 0.4435 | |
| GSE23400 | KCNJ8 | 3764 | 205303_at | 0.0130 | 0.8865 | |
| GSE26886 | KCNJ8 | 3764 | 205303_at | 0.8636 | 0.0149 | |
| GSE29001 | KCNJ8 | 3764 | 205303_at | 0.1741 | 0.5851 | |
| GSE38129 | KCNJ8 | 3764 | 205303_at | -0.2984 | 0.3677 | |
| GSE45670 | KCNJ8 | 3764 | 205303_at | -0.6729 | 0.0239 | |
| GSE53622 | KCNJ8 | 3764 | 56564 | -0.0446 | 0.8347 | |
| GSE53624 | KCNJ8 | 3764 | 56564 | 0.3034 | 0.1303 | |
| GSE63941 | KCNJ8 | 3764 | 205303_at | -2.1509 | 0.0022 | |
| GSE77861 | KCNJ8 | 3764 | 205304_s_at | 0.0685 | 0.6435 | |
| GSE97050 | KCNJ8 | 3764 | A_23_P64879 | -0.2526 | 0.4723 | |
| SRP007169 | KCNJ8 | 3764 | RNAseq | 2.2596 | 0.0020 | |
| SRP064894 | KCNJ8 | 3764 | RNAseq | 1.3742 | 0.0001 | |
| SRP133303 | KCNJ8 | 3764 | RNAseq | 0.4214 | 0.3324 | |
| SRP159526 | KCNJ8 | 3764 | RNAseq | 0.5726 | 0.2604 | |
| SRP219564 | KCNJ8 | 3764 | RNAseq | 0.0261 | 0.9797 | |
| TCGA | KCNJ8 | 3764 | RNAseq | -0.5008 | 0.0007 |
Upregulated datasets: 2; Downregulated datasets: 1.
Survival by KCNJ8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KCNJ8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KCNJ8 | 3764 | 10 | 1 | 19 | |
| GSE20123 | KCNJ8 | 3764 | 9 | 2 | 19 | |
| GSE43470 | KCNJ8 | 3764 | 9 | 4 | 30 | |
| GSE46452 | KCNJ8 | 3764 | 10 | 1 | 48 | |
| GSE47630 | KCNJ8 | 3764 | 14 | 1 | 25 | |
| GSE54993 | KCNJ8 | 3764 | 1 | 9 | 60 | |
| GSE54994 | KCNJ8 | 3764 | 11 | 2 | 40 | |
| GSE60625 | KCNJ8 | 3764 | 0 | 1 | 10 | |
| GSE74703 | KCNJ8 | 3764 | 9 | 3 | 24 | |
| GSE74704 | KCNJ8 | 3764 | 6 | 1 | 13 | |
| TCGA | KCNJ8 | 3764 | 42 | 5 | 49 |
Total number of gains: 121; Total number of losses: 30; Total Number of normals: 337.
Somatic mutations of KCNJ8:
Generating mutation plots.
Highly correlated genes for KCNJ8:
Showing top 20/1340 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KCNJ8 | MRGPRF | 0.792656 | 7 | 0 | 7 |
| KCNJ8 | TNFSF12 | 0.782792 | 3 | 0 | 3 |
| KCNJ8 | C11orf96 | 0.780419 | 4 | 0 | 4 |
| KCNJ8 | LRCH2 | 0.773109 | 6 | 0 | 6 |
| KCNJ8 | PLEKHO1 | 0.762241 | 11 | 0 | 11 |
| KCNJ8 | ANXA6 | 0.761242 | 12 | 0 | 10 |
| KCNJ8 | DCHS1 | 0.755692 | 9 | 0 | 8 |
| KCNJ8 | ARHGAP17 | 0.752438 | 3 | 0 | 3 |
| KCNJ8 | HAGH | 0.750482 | 3 | 0 | 3 |
| KCNJ8 | HMCN1 | 0.749116 | 7 | 0 | 7 |
| KCNJ8 | MRFAP1 | 0.745943 | 3 | 0 | 3 |
| KCNJ8 | MAPRE2 | 0.743178 | 8 | 0 | 8 |
| KCNJ8 | CLMP | 0.739896 | 7 | 0 | 6 |
| KCNJ8 | LIX1L | 0.739426 | 7 | 0 | 6 |
| KCNJ8 | EFEMP2 | 0.735995 | 11 | 0 | 11 |
| KCNJ8 | AP1S2 | 0.735804 | 8 | 0 | 8 |
| KCNJ8 | PMP22 | 0.734188 | 11 | 0 | 11 |
| KCNJ8 | ITM2C | 0.730936 | 8 | 0 | 7 |
| KCNJ8 | BICC1 | 0.730335 | 11 | 0 | 9 |
| KCNJ8 | MAP1A | 0.729938 | 9 | 0 | 8 |
For details and further investigation, click here
