| Full name: integral membrane protein 2C | Alias Symbol: BRI3|E25|hRPC.1050_D_4|ITM3|BRICD2C | ||
| Type: protein-coding gene | Cytoband: 2q37.1 | ||
| Entrez ID: 81618 | HGNC ID: HGNC:6175 | Ensembl Gene: ENSG00000135916 | OMIM ID: 609554 |
| Drug and gene relationship at DGIdb | |||
Expression of ITM2C:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ITM2C | 81618 | 221004_s_at | 0.0375 | 0.9721 | |
| GSE20347 | ITM2C | 81618 | 221004_s_at | 0.5718 | 0.0003 | |
| GSE23400 | ITM2C | 81618 | 221004_s_at | 0.1981 | 0.0373 | |
| GSE26886 | ITM2C | 81618 | 221004_s_at | 1.1639 | 0.0000 | |
| GSE29001 | ITM2C | 81618 | 221004_s_at | 0.7661 | 0.0200 | |
| GSE38129 | ITM2C | 81618 | 221004_s_at | 0.2855 | 0.2359 | |
| GSE45670 | ITM2C | 81618 | 221004_s_at | -0.2354 | 0.2814 | |
| GSE53622 | ITM2C | 81618 | 4489 | 0.4317 | 0.0002 | |
| GSE53624 | ITM2C | 81618 | 4489 | 0.4911 | 0.0000 | |
| GSE63941 | ITM2C | 81618 | 221004_s_at | -0.6352 | 0.3161 | |
| GSE77861 | ITM2C | 81618 | 221004_s_at | 0.5960 | 0.0005 | |
| GSE97050 | ITM2C | 81618 | A_24_P379820 | 0.2753 | 0.4284 | |
| SRP007169 | ITM2C | 81618 | RNAseq | 2.5648 | 0.0000 | |
| SRP008496 | ITM2C | 81618 | RNAseq | 2.7210 | 0.0000 | |
| SRP064894 | ITM2C | 81618 | RNAseq | 0.3027 | 0.2953 | |
| SRP133303 | ITM2C | 81618 | RNAseq | 0.2481 | 0.2104 | |
| SRP159526 | ITM2C | 81618 | RNAseq | 0.7194 | 0.0134 | |
| SRP193095 | ITM2C | 81618 | RNAseq | 0.7076 | 0.0360 | |
| SRP219564 | ITM2C | 81618 | RNAseq | -0.3579 | 0.6550 | |
| TCGA | ITM2C | 81618 | RNAseq | -0.2155 | 0.0132 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by ITM2C expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ITM2C:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ITM2C | 81618 | 1 | 13 | 16 | |
| GSE20123 | ITM2C | 81618 | 1 | 13 | 16 | |
| GSE43470 | ITM2C | 81618 | 2 | 8 | 33 | |
| GSE46452 | ITM2C | 81618 | 0 | 5 | 54 | |
| GSE47630 | ITM2C | 81618 | 4 | 5 | 31 | |
| GSE54993 | ITM2C | 81618 | 2 | 2 | 66 | |
| GSE54994 | ITM2C | 81618 | 6 | 11 | 36 | |
| GSE60625 | ITM2C | 81618 | 0 | 3 | 8 | |
| GSE74703 | ITM2C | 81618 | 2 | 6 | 28 | |
| GSE74704 | ITM2C | 81618 | 1 | 6 | 13 | |
| TCGA | ITM2C | 81618 | 13 | 27 | 56 |
Total number of gains: 32; Total number of losses: 99; Total Number of normals: 357.
Somatic mutations of ITM2C:
Generating mutation plots.
Highly correlated genes for ITM2C:
Showing top 20/1530 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ITM2C | RFTN2 | 0.820162 | 3 | 0 | 3 |
| ITM2C | KHSRP | 0.818336 | 3 | 0 | 3 |
| ITM2C | PSMD3 | 0.815441 | 3 | 0 | 3 |
| ITM2C | PSMD14 | 0.780233 | 3 | 0 | 3 |
| ITM2C | JMY | 0.772551 | 3 | 0 | 3 |
| ITM2C | CCDC59 | 0.77009 | 3 | 0 | 3 |
| ITM2C | RIOK1 | 0.763321 | 3 | 0 | 3 |
| ITM2C | ADCY3 | 0.74147 | 5 | 0 | 5 |
| ITM2C | FAM32A | 0.739501 | 3 | 0 | 3 |
| ITM2C | RTKN | 0.73741 | 3 | 0 | 3 |
| ITM2C | DOCK11 | 0.736202 | 6 | 0 | 5 |
| ITM2C | PES1 | 0.735936 | 4 | 0 | 4 |
| ITM2C | KCNJ8 | 0.730936 | 8 | 0 | 7 |
| ITM2C | DERL3 | 0.730865 | 3 | 0 | 3 |
| ITM2C | HSPA5 | 0.730201 | 3 | 0 | 3 |
| ITM2C | ERRFI1 | 0.728706 | 3 | 0 | 3 |
| ITM2C | C20orf194 | 0.727657 | 3 | 0 | 3 |
| ITM2C | GHDC | 0.725568 | 3 | 0 | 3 |
| ITM2C | CRTC2 | 0.724141 | 3 | 0 | 3 |
| ITM2C | ALG1 | 0.723527 | 3 | 0 | 3 |
For details and further investigation, click here
