| Full name: lysyl oxidase like 4 | Alias Symbol: FLJ21889|LOXC | ||
| Type: protein-coding gene | Cytoband: 10q24.2 | ||
| Entrez ID: 84171 | HGNC ID: HGNC:17171 | Ensembl Gene: ENSG00000138131 | OMIM ID: 607318 |
| Drug and gene relationship at DGIdb | |||
Expression of LOXL4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LOXL4 | 84171 | 227145_at | 0.2428 | 0.8710 | |
| GSE26886 | LOXL4 | 84171 | 227145_at | 1.4229 | 0.0034 | |
| GSE45670 | LOXL4 | 84171 | 227145_at | -0.0373 | 0.9201 | |
| GSE53622 | LOXL4 | 84171 | 125101 | 0.7319 | 0.0129 | |
| GSE53624 | LOXL4 | 84171 | 125101 | 0.6475 | 0.0026 | |
| GSE63941 | LOXL4 | 84171 | 227145_at | -1.1541 | 0.3610 | |
| GSE77861 | LOXL4 | 84171 | 227145_at | 0.2888 | 0.5644 | |
| GSE97050 | LOXL4 | 84171 | A_24_P406754 | -0.1576 | 0.5410 | |
| SRP007169 | LOXL4 | 84171 | RNAseq | 4.4398 | 0.0002 | |
| SRP064894 | LOXL4 | 84171 | RNAseq | 0.4987 | 0.2898 | |
| SRP133303 | LOXL4 | 84171 | RNAseq | -0.1356 | 0.7088 | |
| SRP159526 | LOXL4 | 84171 | RNAseq | 2.3150 | 0.0001 | |
| SRP193095 | LOXL4 | 84171 | RNAseq | 2.3469 | 0.0000 | |
| SRP219564 | LOXL4 | 84171 | RNAseq | 1.5015 | 0.1651 | |
| TCGA | LOXL4 | 84171 | RNAseq | 0.5214 | 0.1050 |
Upregulated datasets: 4; Downregulated datasets: 0.
Survival by LOXL4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LOXL4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LOXL4 | 84171 | 1 | 8 | 21 | |
| GSE20123 | LOXL4 | 84171 | 1 | 7 | 22 | |
| GSE43470 | LOXL4 | 84171 | 0 | 7 | 36 | |
| GSE46452 | LOXL4 | 84171 | 0 | 11 | 48 | |
| GSE47630 | LOXL4 | 84171 | 2 | 14 | 24 | |
| GSE54993 | LOXL4 | 84171 | 8 | 0 | 62 | |
| GSE54994 | LOXL4 | 84171 | 2 | 11 | 40 | |
| GSE60625 | LOXL4 | 84171 | 0 | 0 | 11 | |
| GSE74703 | LOXL4 | 84171 | 0 | 5 | 31 | |
| GSE74704 | LOXL4 | 84171 | 0 | 4 | 16 | |
| TCGA | LOXL4 | 84171 | 5 | 28 | 63 |
Total number of gains: 19; Total number of losses: 95; Total Number of normals: 374.
Somatic mutations of LOXL4:
Generating mutation plots.
Highly correlated genes for LOXL4:
Showing top 20/228 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LOXL4 | SNX19 | 0.818887 | 3 | 0 | 3 |
| LOXL4 | TUBGCP4 | 0.742036 | 3 | 0 | 3 |
| LOXL4 | POLDIP3 | 0.734298 | 3 | 0 | 3 |
| LOXL4 | STRADA | 0.729598 | 3 | 0 | 3 |
| LOXL4 | NECAP1 | 0.725134 | 3 | 0 | 3 |
| LOXL4 | BAD | 0.722656 | 3 | 0 | 3 |
| LOXL4 | BRCA2 | 0.721786 | 3 | 0 | 3 |
| LOXL4 | CTPS2 | 0.721586 | 3 | 0 | 3 |
| LOXL4 | LRRK1 | 0.720728 | 3 | 0 | 3 |
| LOXL4 | TCTN3 | 0.720152 | 3 | 0 | 3 |
| LOXL4 | SLC38A10 | 0.720027 | 4 | 0 | 3 |
| LOXL4 | HERC2 | 0.712307 | 4 | 0 | 4 |
| LOXL4 | KDM5A | 0.711952 | 3 | 0 | 3 |
| LOXL4 | NAPEPLD | 0.70883 | 3 | 0 | 3 |
| LOXL4 | KCNE3 | 0.706284 | 4 | 0 | 3 |
| LOXL4 | LYN | 0.704909 | 3 | 0 | 3 |
| LOXL4 | IDS | 0.703775 | 3 | 0 | 3 |
| LOXL4 | RBL2 | 0.702022 | 3 | 0 | 3 |
| LOXL4 | LTBR | 0.700371 | 3 | 0 | 3 |
| LOXL4 | EIF3F | 0.697869 | 3 | 0 | 3 |
For details and further investigation, click here
