CHD8

 

Full name: chromodomain helicase DNA binding protein 8 Alias Symbol: KIAA1564|DUPLIN
Type: protein-coding gene Cytoband: 14q11.2
Entrez ID: 57680 HGNC ID: HGNC:20153 Ensembl Gene: ENSG00000100888 OMIM ID: 610528
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 23/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

CHD8 involved pathways:

KEGG pathway Description View
hsa04310Wnt signaling pathway

 

Expression of CHD8:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 CHD8 57680 212571_at 0.7113 0.3317
GSE20347 CHD8 57680 212571_at 0.2431 0.0741
GSE23400 CHD8 57680 212571_at 0.4007 0.0000
GSE26886 CHD8 57680 212571_at 0.2701 0.1074
GSE29001 CHD8 57680 212571_at 0.1679 0.4257
GSE38129 CHD8 57680 212571_at 0.1352 0.1659
GSE45670 CHD8 57680 212571_at 0.5634 0.0001
GSE53622 CHD8 57680 7872 0.0711 0.3226
GSE53624 CHD8 57680 7872 0.3116 0.0000
GSE63941 CHD8 57680 212571_at 0.8340 0.0015
GSE77861 CHD8 57680 212571_at 0.8998 0.0343
GSE97050 CHD8 57680 A_24_P361167 0.1867 0.3716
SRP007169 CHD8 57680 RNAseq 1.0650 0.0151
SRP008496 CHD8 57680 RNAseq 0.9576 0.0025
SRP064894 CHD8 57680 RNAseq 0.1534 0.3238
SRP133303 CHD8 57680 RNAseq 0.3759 0.0765
SRP159526 CHD8 57680 RNAseq 0.1620 0.2510
SRP193095 CHD8 57680 RNAseq 0.2940 0.0053
SRP219564 CHD8 57680 RNAseq 0.2395 0.3496
TCGA CHD8 57680 RNAseq 0.0257 0.5550

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by CHD8 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of CHD8:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 CHD8 57680 9 3 18
GSE20123 CHD8 57680 9 3 18
GSE43470 CHD8 57680 7 2 34
GSE46452 CHD8 57680 18 2 39
GSE47630 CHD8 57680 10 10 20
GSE54993 CHD8 57680 3 11 56
GSE54994 CHD8 57680 18 5 30
GSE60625 CHD8 57680 0 2 9
GSE74703 CHD8 57680 6 2 28
GSE74704 CHD8 57680 4 2 14
TCGA CHD8 57680 27 16 53

Total number of gains: 111; Total number of losses: 58; Total Number of normals: 319.  

 

Somatic mutations of CHD8:

 

Generating mutation plots.

 

Highly correlated genes for CHD8:

 

Showing top 20/883 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
CHD8LYAR0.797285303
CHD8PMS10.79182303
CHD8ARF10.7855303
CHD8DGKH0.783953303
CHD8LYSMD10.759854303
CHD8RLIM0.751918303
CHD8DHX570.74823303
CHD8MTRR0.748124303
CHD8FLVCR10.738208303
CHD8PIP4K2C0.730403303
CHD8SIPA1L20.7287303
CHD8KDM5A0.727845303
CHD8ASS10.72676303
CHD8IL17RD0.725792303
CHD8NUCKS10.724706606
CHD8SFMBT10.722572303
CHD8ELOF10.7224403
CHD8FUCA20.721065404
CHD8MATR30.719095303
CHD8PNPLA60.714479303

For details and further investigation, click here