KEAP1

 

Full name: kelch like ECH associated protein 1 Alias Symbol: KIAA0132|MGC10630|MGC1114|MGC20887|MGC4407|MGC9454|INrf2|KLHL19
Type: protein-coding gene Cytoband: 19p13.2
Entrez ID: 9817 HGNC ID: HGNC:23177 Ensembl Gene: ENSG00000079999 OMIM ID: 606016
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 18/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of KEAP1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 KEAP1 9817 202417_at 0.3523 0.5722
GSE20347 KEAP1 9817 202417_at 0.3613 0.0027
GSE23400 KEAP1 9817 202417_at 0.4280 0.0000
GSE26886 KEAP1 9817 202417_at 0.0182 0.9567
GSE29001 KEAP1 9817 202417_at 0.2770 0.4318
GSE38129 KEAP1 9817 202417_at 0.4778 0.0002
GSE45670 KEAP1 9817 202417_at 0.3385 0.0589
GSE53622 KEAP1 9817 47533 0.1182 0.1540
GSE53624 KEAP1 9817 47533 0.2682 0.0001
GSE63941 KEAP1 9817 202417_at -0.2330 0.6224
GSE77861 KEAP1 9817 202417_at 0.6023 0.0341
GSE97050 KEAP1 9817 A_23_P119141 0.0477 0.8226
SRP007169 KEAP1 9817 RNAseq -0.2911 0.4337
SRP008496 KEAP1 9817 RNAseq -0.2255 0.2892
SRP064894 KEAP1 9817 RNAseq 0.2993 0.1644
SRP133303 KEAP1 9817 RNAseq 0.0708 0.6903
SRP159526 KEAP1 9817 RNAseq 0.3465 0.2091
SRP193095 KEAP1 9817 RNAseq 0.1114 0.4540
SRP219564 KEAP1 9817 RNAseq 0.2270 0.4524
TCGA KEAP1 9817 RNAseq 0.1827 0.0003

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by KEAP1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of KEAP1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 KEAP1 9817 4 3 23
GSE20123 KEAP1 9817 3 1 26
GSE43470 KEAP1 9817 3 6 34
GSE46452 KEAP1 9817 47 1 11
GSE47630 KEAP1 9817 4 7 29
GSE54993 KEAP1 9817 16 3 51
GSE54994 KEAP1 9817 7 13 33
GSE60625 KEAP1 9817 9 0 2
GSE74703 KEAP1 9817 3 4 29
GSE74704 KEAP1 9817 0 1 19
TCGA KEAP1 9817 14 15 67

Total number of gains: 110; Total number of losses: 54; Total Number of normals: 324.  

 

Somatic mutations of KEAP1:

 

Generating mutation plots.

 

Highly correlated genes for KEAP1:

 

Showing top 20/1005 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
KEAP1KLHL130.795835303
KEAP1MCOLN10.789999303
KEAP1YIPF30.783363303
KEAP1SNRPN0.775273303
KEAP1PRR130.756617303
KEAP1BRAT10.755181303
KEAP1TP53I130.754856303
KEAP1PRR140.742525404
KEAP1THADA0.741706303
KEAP1NACC10.741572404
KEAP1MRPL380.737522303
KEAP1MON1A0.734663303
KEAP1KLHDC30.731531303
KEAP1TMEM63B0.731082303
KEAP1SETD1A0.728394303
KEAP1MEX3C0.728124303
KEAP1CHST120.726472303
KEAP1EEFSEC0.725611303
KEAP1SLC45A40.722252303
KEAP1ZNF4080.720621303

For details and further investigation, click here