| Full name: Kell metallo-endopeptidase (Kell blood group) | Alias Symbol: ECE3|CD238 | ||
| Type: protein-coding gene | Cytoband: 7q34 | ||
| Entrez ID: 3792 | HGNC ID: HGNC:6308 | Ensembl Gene: ENSG00000197993 | OMIM ID: 613883 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of KEL:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KEL | 3792 | 206077_at | -0.3582 | 0.1872 | |
| GSE20347 | KEL | 3792 | 206077_at | -0.1322 | 0.2583 | |
| GSE23400 | KEL | 3792 | 206077_at | -0.1192 | 0.0002 | |
| GSE26886 | KEL | 3792 | 206077_at | -0.3165 | 0.0118 | |
| GSE29001 | KEL | 3792 | 206077_at | -0.3428 | 0.0390 | |
| GSE38129 | KEL | 3792 | 206077_at | -0.2441 | 0.0624 | |
| GSE45670 | KEL | 3792 | 206077_at | -0.3480 | 0.0083 | |
| GSE53622 | KEL | 3792 | 4501 | -1.1649 | 0.0000 | |
| GSE53624 | KEL | 3792 | 4501 | -2.2038 | 0.0000 | |
| GSE63941 | KEL | 3792 | 206077_at | 0.2909 | 0.0656 | |
| GSE77861 | KEL | 3792 | 206077_at | -0.2279 | 0.0389 | |
| GSE97050 | KEL | 3792 | A_23_P252758 | -0.1386 | 0.6594 | |
| SRP159526 | KEL | 3792 | RNAseq | -1.4798 | 0.0175 | |
| TCGA | KEL | 3792 | RNAseq | 0.1834 | 0.8161 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by KEL expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KEL:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KEL | 3792 | 4 | 2 | 24 | |
| GSE20123 | KEL | 3792 | 4 | 2 | 24 | |
| GSE43470 | KEL | 3792 | 2 | 4 | 37 | |
| GSE46452 | KEL | 3792 | 7 | 2 | 50 | |
| GSE47630 | KEL | 3792 | 6 | 7 | 27 | |
| GSE54993 | KEL | 3792 | 3 | 4 | 63 | |
| GSE54994 | KEL | 3792 | 5 | 8 | 40 | |
| GSE60625 | KEL | 3792 | 0 | 0 | 11 | |
| GSE74703 | KEL | 3792 | 2 | 4 | 30 | |
| GSE74704 | KEL | 3792 | 2 | 2 | 16 | |
| TCGA | KEL | 3792 | 28 | 24 | 44 |
Total number of gains: 63; Total number of losses: 59; Total Number of normals: 366.
Somatic mutations of KEL:
Generating mutation plots.
Highly correlated genes for KEL:
Showing top 20/996 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KEL | CAMKMT | 0.710799 | 3 | 0 | 3 |
| KEL | AMBRA1 | 0.705674 | 3 | 0 | 3 |
| KEL | METTL9 | 0.701282 | 3 | 0 | 3 |
| KEL | NUCB1 | 0.697958 | 4 | 0 | 4 |
| KEL | MROH8 | 0.694188 | 3 | 0 | 3 |
| KEL | C11orf68 | 0.689822 | 3 | 0 | 3 |
| KEL | SPRYD4 | 0.680971 | 4 | 0 | 4 |
| KEL | ARF5 | 0.672229 | 4 | 0 | 4 |
| KEL | SNORA68 | 0.670803 | 4 | 0 | 3 |
| KEL | C9orf16 | 0.667583 | 4 | 0 | 3 |
| KEL | SLC10A5 | 0.657603 | 3 | 0 | 3 |
| KEL | ASPG | 0.657508 | 6 | 0 | 6 |
| KEL | ZER1 | 0.654669 | 3 | 0 | 3 |
| KEL | C3orf80 | 0.653742 | 3 | 0 | 3 |
| KEL | CCDC12 | 0.652306 | 6 | 0 | 5 |
| KEL | DPH3 | 0.650886 | 3 | 0 | 3 |
| KEL | SLC18A1 | 0.648181 | 3 | 0 | 3 |
| KEL | MSH4 | 0.644666 | 4 | 0 | 3 |
| KEL | SUCLG2 | 0.643032 | 5 | 0 | 5 |
| KEL | LINC00661 | 0.642174 | 3 | 0 | 3 |
For details and further investigation, click here
