| Full name: prune homolog 2 with BCH domain | Alias Symbol: BMCC1|BNIPXL|A214N16.3|bA214N16.3 | ||
| Type: protein-coding gene | Cytoband: 9q21.2 | ||
| Entrez ID: 158471 | HGNC ID: HGNC:25209 | Ensembl Gene: ENSG00000106772 | OMIM ID: 610691 |
| Drug and gene relationship at DGIdb | |||
Expression of PRUNE2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PRUNE2 | 158471 | 212805_at | -2.8816 | 0.1056 | |
| GSE20347 | PRUNE2 | 158471 | 212805_at | -0.7488 | 0.0712 | |
| GSE23400 | PRUNE2 | 158471 | 212805_at | -0.9644 | 0.0004 | |
| GSE26886 | PRUNE2 | 158471 | 212805_at | 1.4457 | 0.0103 | |
| GSE29001 | PRUNE2 | 158471 | 212805_at | -0.9413 | 0.0646 | |
| GSE38129 | PRUNE2 | 158471 | 212805_at | -1.3777 | 0.0087 | |
| GSE45670 | PRUNE2 | 158471 | 212805_at | -4.0976 | 0.0000 | |
| GSE53622 | PRUNE2 | 158471 | 85505 | -2.5459 | 0.0000 | |
| GSE53624 | PRUNE2 | 158471 | 39765 | -2.5297 | 0.0000 | |
| GSE63941 | PRUNE2 | 158471 | 212805_at | -4.2237 | 0.0000 | |
| GSE77861 | PRUNE2 | 158471 | 212805_at | -0.0640 | 0.8293 | |
| GSE97050 | PRUNE2 | 158471 | A_33_P3294921 | -1.2772 | 0.1560 | |
| SRP007169 | PRUNE2 | 158471 | RNAseq | 4.2352 | 0.0000 | |
| SRP064894 | PRUNE2 | 158471 | RNAseq | -0.7519 | 0.1269 | |
| SRP133303 | PRUNE2 | 158471 | RNAseq | -0.3095 | 0.7302 | |
| SRP159526 | PRUNE2 | 158471 | RNAseq | -1.5417 | 0.0345 | |
| SRP193095 | PRUNE2 | 158471 | RNAseq | -0.5827 | 0.2871 | |
| SRP219564 | PRUNE2 | 158471 | RNAseq | -0.3813 | 0.6811 | |
| TCGA | PRUNE2 | 158471 | RNAseq | -1.0300 | 0.0006 |
Upregulated datasets: 2; Downregulated datasets: 7.
Survival by PRUNE2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PRUNE2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PRUNE2 | 158471 | 6 | 10 | 14 | |
| GSE20123 | PRUNE2 | 158471 | 6 | 10 | 14 | |
| GSE43470 | PRUNE2 | 158471 | 6 | 5 | 32 | |
| GSE46452 | PRUNE2 | 158471 | 6 | 14 | 39 | |
| GSE47630 | PRUNE2 | 158471 | 1 | 18 | 21 | |
| GSE54993 | PRUNE2 | 158471 | 4 | 2 | 64 | |
| GSE54994 | PRUNE2 | 158471 | 4 | 12 | 37 | |
| GSE60625 | PRUNE2 | 158471 | 0 | 0 | 11 | |
| GSE74703 | PRUNE2 | 158471 | 5 | 4 | 27 | |
| GSE74704 | PRUNE2 | 158471 | 3 | 7 | 10 | |
| TCGA | PRUNE2 | 158471 | 18 | 28 | 50 |
Total number of gains: 59; Total number of losses: 110; Total Number of normals: 319.
Somatic mutations of PRUNE2:
Generating mutation plots.
Highly correlated genes for PRUNE2:
Showing top 20/1135 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PRUNE2 | LMOD1 | 0.877186 | 13 | 0 | 13 |
| PRUNE2 | CASQ2 | 0.85564 | 10 | 0 | 10 |
| PRUNE2 | PLN | 0.855627 | 13 | 0 | 13 |
| PRUNE2 | MYOCD | 0.854114 | 7 | 0 | 7 |
| PRUNE2 | AFF3 | 0.840455 | 3 | 0 | 3 |
| PRUNE2 | CNN1 | 0.838935 | 11 | 0 | 11 |
| PRUNE2 | CHRDL1 | 0.837695 | 10 | 0 | 10 |
| PRUNE2 | SORCS1 | 0.831777 | 4 | 0 | 4 |
| PRUNE2 | MYH11 | 0.824894 | 12 | 0 | 12 |
| PRUNE2 | NEXN | 0.822629 | 9 | 0 | 9 |
| PRUNE2 | ACTG2 | 0.822152 | 13 | 0 | 13 |
| PRUNE2 | PCP4 | 0.810404 | 11 | 0 | 11 |
| PRUNE2 | PPP1R12B | 0.809919 | 12 | 0 | 11 |
| PRUNE2 | SYNM | 0.8091 | 12 | 0 | 11 |
| PRUNE2 | PDZRN4 | 0.808756 | 10 | 0 | 10 |
| PRUNE2 | C1QTNF7 | 0.808611 | 5 | 0 | 5 |
| PRUNE2 | MIR100HG | 0.808563 | 6 | 0 | 6 |
| PRUNE2 | PTCHD1 | 0.807129 | 5 | 0 | 5 |
| PRUNE2 | RBFOX3 | 0.806563 | 3 | 0 | 3 |
| PRUNE2 | PARD3B | 0.802941 | 5 | 0 | 5 |
For details and further investigation, click here
