| Full name: killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 | Alias Symbol: 103AS|15.212|CD158D | ||
| Type: protein-coding gene | Cytoband: 19q13.42 | ||
| Entrez ID: 3805 | HGNC ID: HGNC:6332 | Ensembl Gene: ENSG00000189013 | OMIM ID: 604945 |
| Drug and gene relationship at DGIdb | |||
KIR2DL4 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04612 | Antigen processing and presentation | |
| hsa04650 | Natural killer cell mediated cytotoxicity |
Expression of KIR2DL4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KIR2DL4 | 3805 | 208426_x_at | 0.2801 | 0.4061 | |
| GSE20347 | KIR2DL4 | 3805 | 211245_x_at | 0.1310 | 0.0810 | |
| GSE23400 | KIR2DL4 | 3805 | 208426_x_at | -0.1795 | 0.0000 | |
| GSE26886 | KIR2DL4 | 3805 | 211242_x_at | -0.0150 | 0.9348 | |
| GSE29001 | KIR2DL4 | 3805 | 208426_x_at | 0.0679 | 0.7859 | |
| GSE38129 | KIR2DL4 | 3805 | 211242_x_at | -0.0939 | 0.2886 | |
| GSE45670 | KIR2DL4 | 3805 | 208426_x_at | 0.2121 | 0.1406 | |
| GSE53622 | KIR2DL4 | 3805 | 29823 | 0.6325 | 0.0000 | |
| GSE53624 | KIR2DL4 | 3805 | 29823 | 0.5700 | 0.0000 | |
| GSE63941 | KIR2DL4 | 3805 | 211245_x_at | -0.0444 | 0.8228 | |
| GSE77861 | KIR2DL4 | 3805 | 211245_x_at | -0.0055 | 0.9703 | |
| GSE97050 | KIR2DL4 | 3805 | A_24_P288298 | 0.5932 | 0.3542 | |
| TCGA | KIR2DL4 | 3805 | RNAseq | 1.4036 | 0.0206 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by KIR2DL4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KIR2DL4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KIR2DL4 | 3805 | 3 | 4 | 23 | |
| GSE20123 | KIR2DL4 | 3805 | 3 | 3 | 24 | |
| GSE43470 | KIR2DL4 | 3805 | 3 | 11 | 29 | |
| GSE46452 | KIR2DL4 | 3805 | 45 | 1 | 13 | |
| GSE47630 | KIR2DL4 | 3805 | 8 | 6 | 26 | |
| GSE54993 | KIR2DL4 | 3805 | 17 | 4 | 49 | |
| GSE54994 | KIR2DL4 | 3805 | 4 | 13 | 36 | |
| GSE60625 | KIR2DL4 | 3805 | 9 | 0 | 2 | |
| GSE74703 | KIR2DL4 | 3805 | 3 | 7 | 26 | |
| GSE74704 | KIR2DL4 | 3805 | 3 | 1 | 16 | |
| TCGA | KIR2DL4 | 3805 | 19 | 14 | 63 |
Total number of gains: 117; Total number of losses: 64; Total Number of normals: 307.
Somatic mutations of KIR2DL4:
Generating mutation plots.
Highly correlated genes for KIR2DL4:
Showing top 20/487 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KIR2DL4 | RAC3 | 0.7033 | 3 | 0 | 3 |
| KIR2DL4 | NAT2 | 0.693837 | 5 | 0 | 5 |
| KIR2DL4 | LINC00574 | 0.693593 | 5 | 0 | 5 |
| KIR2DL4 | NTNG1 | 0.692958 | 4 | 0 | 4 |
| KIR2DL4 | RPGRIP1 | 0.688312 | 5 | 0 | 5 |
| KIR2DL4 | RNF185-AS1 | 0.6813 | 4 | 0 | 4 |
| KIR2DL4 | ITGAX | 0.678181 | 3 | 0 | 3 |
| KIR2DL4 | MED24 | 0.67467 | 8 | 0 | 6 |
| KIR2DL4 | SLC6A5 | 0.673757 | 4 | 0 | 3 |
| KIR2DL4 | TAF6L | 0.667456 | 4 | 0 | 3 |
| KIR2DL4 | NMBR | 0.666631 | 5 | 0 | 5 |
| KIR2DL4 | SLC17A1 | 0.65573 | 4 | 0 | 3 |
| KIR2DL4 | EXOC3L2 | 0.65286 | 3 | 0 | 3 |
| KIR2DL4 | SYN1 | 0.652827 | 6 | 0 | 5 |
| KIR2DL4 | FCAR | 0.652735 | 5 | 0 | 4 |
| KIR2DL4 | SPINK2 | 0.652219 | 3 | 0 | 3 |
| KIR2DL4 | MAS1 | 0.650114 | 5 | 0 | 4 |
| KIR2DL4 | CRHBP | 0.648777 | 4 | 0 | 4 |
| KIR2DL4 | IRF1 | 0.648193 | 4 | 0 | 4 |
| KIR2DL4 | KIR3DL3 | 0.647479 | 7 | 0 | 6 |
For details and further investigation, click here
