RAC3

 

Full name: Rac family small GTPase 3 Alias Symbol: 
Type: protein-coding gene Cytoband: 17q25.3
Entrez ID: 5881 HGNC ID: HGNC:9803 Ensembl Gene: ENSG00000169750 OMIM ID: 602050
Drug and gene relationship at DGIdb

 

RAC3 involved pathways:

KEGG pathway Description View
hsa04010MAPK signaling pathway
hsa04014Ras signaling pathway
hsa04015Rap1 signaling pathway
hsa04024cAMP signaling pathway
hsa04071Sphingolipid signaling pathway
hsa04310Wnt signaling pathway
hsa04360Axon guidance
hsa04370VEGF signaling pathway
hsa04510Focal adhesion
hsa04520Adherens junction
hsa04650Natural killer cell mediated cytotoxicity
hsa04662B cell receptor signaling pathway
hsa04664Fc epsilon RI signaling pathway
hsa04810Regulation of actin cytoskeleton
hsa05200Pathways in cancer
hsa05210Colorectal cancer
hsa05212Pancreatic cancer
hsa05231Choline metabolism in cancer

 

Expression of RAC3:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 RAC3 5881 206103_at 0.8799 0.1310
GSE20347 RAC3 5881 206103_at 0.0256 0.7627
GSE23400 RAC3 5881 206103_at 0.2336 0.0001
GSE26886 RAC3 5881 206103_at 0.3264 0.0150
GSE29001 RAC3 5881 206103_at 0.0298 0.8525
GSE38129 RAC3 5881 206103_at 0.3520 0.0260
GSE45670 RAC3 5881 206103_at 0.3333 0.0979
GSE63941 RAC3 5881 206103_at 1.5450 0.0018
GSE77861 RAC3 5881 206103_at 0.1279 0.4098
GSE97050 RAC3 5881 A_33_P3295523 0.1615 0.6717
SRP007169 RAC3 5881 RNAseq 0.9170 0.0659
SRP008496 RAC3 5881 RNAseq 0.2824 0.4924
SRP064894 RAC3 5881 RNAseq 1.8367 0.0000
SRP133303 RAC3 5881 RNAseq 0.6158 0.2151
SRP159526 RAC3 5881 RNAseq 1.4779 0.0047
SRP193095 RAC3 5881 RNAseq 1.0322 0.0000
SRP219564 RAC3 5881 RNAseq 1.0111 0.1161
TCGA RAC3 5881 RNAseq 0.3061 0.0702

Upregulated datasets: 4; Downregulated datasets: 0.  

 

Survival by RAC3 expression:

 

TCGA

 

Note: Click image to view full size file.  

Copy number change of RAC3:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 RAC3 5881 4 4 22
GSE20123 RAC3 5881 4 4 22
GSE43470 RAC3 5881 3 5 35
GSE46452 RAC3 5881 34 0 25
GSE47630 RAC3 5881 9 2 29
GSE54993 RAC3 5881 2 5 63
GSE54994 RAC3 5881 10 6 37
GSE60625 RAC3 5881 6 0 5
GSE74703 RAC3 5881 3 3 30
GSE74704 RAC3 5881 4 3 13
TCGA RAC3 5881 24 13 59

Total number of gains: 103; Total number of losses: 45; Total Number of normals: 340.  

 

Somatic mutations of RAC3:

 

Generating mutation plots.

 

Highly correlated genes for RAC3:

 

Showing top 20/669 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
RAC3SPATS20.757683303
RAC3CMTM40.748077303
RAC3ARFRP10.745617303
RAC3KPTN0.737247303
RAC3DNAH170.735967303
RAC3TAF4B0.72862303
RAC3DCXR0.721628303
RAC3SAMD10.716812505
RAC3KCNC40.713507404
RAC3MSTO10.712963403
RAC3PLXNB20.711765303
RAC3MEX3A0.705175303
RAC3FGF110.704983404
RAC3LAGE30.704504505
RAC3KIR2DL40.7033303
RAC3IL4I10.702729303
RAC3XKR80.696837303
RAC3DPP90.686301303
RAC3STK40.680883303
RAC3CHORDC10.678894303

For details and further investigation, click here