IRF1

 

Full name: interferon regulatory factor 1 Alias Symbol: MAR
Type: protein-coding gene Cytoband: 5q31.1
Entrez ID: 3659 HGNC ID: HGNC:6116 Ensembl Gene: ENSG00000125347 OMIM ID: 147575
Drug and gene relationship at DGIdb

 

IRF1 involved pathways:

KEGG pathway Description View
hsa04917Prolactin signaling pathway
hsa05133Pertussis
hsa05160Hepatitis C

 

Expression of IRF1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 IRF1 3659 202531_at 0.6631 0.1030
GSE20347 IRF1 3659 202531_at 0.5698 0.0052
GSE23400 IRF1 3659 202531_at 0.3328 0.0064
GSE26886 IRF1 3659 238725_at 0.5490 0.2892
GSE29001 IRF1 3659 202531_at 0.5110 0.0068
GSE38129 IRF1 3659 202531_at 0.3098 0.1876
GSE45670 IRF1 3659 202531_at 0.5122 0.1306
GSE53622 IRF1 3659 122025 0.4973 0.0053
GSE53624 IRF1 3659 122025 0.5846 0.0000
GSE63941 IRF1 3659 202531_at -0.1102 0.9175
GSE77861 IRF1 3659 202531_at 0.1384 0.6166
GSE97050 IRF1 3659 A_23_P41765 -0.4651 0.2206
SRP007169 IRF1 3659 RNAseq -0.2388 0.5836
SRP008496 IRF1 3659 RNAseq -0.1709 0.5292
SRP064894 IRF1 3659 RNAseq 0.0960 0.6874
SRP133303 IRF1 3659 RNAseq 0.5061 0.0450
SRP159526 IRF1 3659 RNAseq 0.1783 0.7561
SRP193095 IRF1 3659 RNAseq 0.4608 0.0248
SRP219564 IRF1 3659 RNAseq 0.9935 0.1851
TCGA IRF1 3659 RNAseq 0.1429 0.1492

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by IRF1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of IRF1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 IRF1 3659 1 11 18
GSE20123 IRF1 3659 2 11 17
GSE43470 IRF1 3659 2 9 32
GSE46452 IRF1 3659 0 27 32
GSE47630 IRF1 3659 0 21 19
GSE54993 IRF1 3659 9 1 60
GSE54994 IRF1 3659 2 14 37
GSE60625 IRF1 3659 0 0 11
GSE74703 IRF1 3659 2 6 28
GSE74704 IRF1 3659 1 5 14
TCGA IRF1 3659 3 39 54

Total number of gains: 22; Total number of losses: 144; Total Number of normals: 322.  

 

Somatic mutations of IRF1:

 

Generating mutation plots.

 

Highly correlated genes for IRF1:

 

Showing top 20/530 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
IRF1VAPB0.766404303
IRF1CCDC1270.762403303
IRF1PHTF10.760256303
IRF1HIC10.735881303
IRF1PPP3CB0.733191303
IRF1NAPB0.726943303
IRF1AZIN10.716405303
IRF1MAPRE10.709968303
IRF1WDR50.705239303
IRF1ASXL10.699578503
IRF1GZMB0.69739910010
IRF1IFNAR10.690371303
IRF1TAP10.6884511010
IRF1SLC12A40.686952303
IRF1BAG20.685098303
IRF1UQCC10.68338303
IRF1RRM2B0.682513404
IRF1TMEM185B0.679637303
IRF1DHX350.679095303
IRF1DHX380.678997303

For details and further investigation, click here