SH2B3

 

Full name: SH2B adaptor protein 3 Alias Symbol: LNK|IDDM20
Type: protein-coding gene Cytoband: 12q24.12
Entrez ID: 10019 HGNC ID: HGNC:29605 Ensembl Gene: ENSG00000111252 OMIM ID: 605093
Drug and gene relationship at DGIdb

 

SH2B3 involved pathways:

KEGG pathway Description View
hsa04722Neurotrophin signaling pathway

 

Expression of SH2B3:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 SH2B3 10019 203320_at 0.3781 0.5291
GSE20347 SH2B3 10019 203320_at 0.3701 0.0010
GSE23400 SH2B3 10019 203320_at 0.2342 0.0075
GSE26886 SH2B3 10019 203320_at 0.5798 0.1282
GSE29001 SH2B3 10019 203320_at 0.3241 0.1353
GSE38129 SH2B3 10019 203320_at 0.2472 0.2740
GSE45670 SH2B3 10019 203320_at -0.2065 0.5562
GSE53622 SH2B3 10019 10170 0.4550 0.0003
GSE53624 SH2B3 10019 10170 0.6178 0.0000
GSE63941 SH2B3 10019 203320_at -2.2239 0.0010
GSE77861 SH2B3 10019 203320_at 0.2177 0.1963
GSE97050 SH2B3 10019 A_24_P201739 0.5265 0.1616
SRP007169 SH2B3 10019 RNAseq 2.2839 0.0007
SRP008496 SH2B3 10019 RNAseq 2.3618 0.0000
SRP064894 SH2B3 10019 RNAseq 0.6553 0.0129
SRP133303 SH2B3 10019 RNAseq 0.0369 0.8312
SRP159526 SH2B3 10019 RNAseq 0.4578 0.1691
SRP193095 SH2B3 10019 RNAseq 0.9834 0.0000
SRP219564 SH2B3 10019 RNAseq 0.5889 0.2427
TCGA SH2B3 10019 RNAseq 0.0681 0.4257

Upregulated datasets: 2; Downregulated datasets: 1.  

 

Survival by SH2B3 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of SH2B3:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 SH2B3 10019 5 3 22
GSE20123 SH2B3 10019 5 3 22
GSE43470 SH2B3 10019 2 1 40
GSE46452 SH2B3 10019 9 1 49
GSE47630 SH2B3 10019 9 3 28
GSE54993 SH2B3 10019 0 5 65
GSE54994 SH2B3 10019 4 2 47
GSE60625 SH2B3 10019 0 0 11
GSE74703 SH2B3 10019 2 0 34
GSE74704 SH2B3 10019 2 2 16
TCGA SH2B3 10019 22 11 63

Total number of gains: 60; Total number of losses: 31; Total Number of normals: 397.  

 

Somatic mutations of SH2B3:

 

Generating mutation plots.

 

Highly correlated genes for SH2B3:

 

Showing top 20/1355 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
SH2B3FCGR3A0.807128303
SH2B3ENTPD40.786717303
SH2B3C19orf380.784284303
SH2B3CERKL0.761219303
SH2B3DERL30.759407303
SH2B3SAMM500.758727303
SH2B3GPR1410.749682303
SH2B3ZNF180.746883303
SH2B3DEGS10.744301303
SH2B3TMEM200A0.742842707
SH2B3DRAM10.73684413012
SH2B3ITGAM0.734832908
SH2B3SUSD10.728066404
SH2B3GLI20.724662404
SH2B3BICC10.720563909
SH2B3DNM3OS0.719149303
SH2B3KLHL210.717975303
SH2B3A1BG0.716341303
SH2B3TNFRSF1B0.71523211011
SH2B3C1S0.71206212012

For details and further investigation, click here