| Full name: kallikrein 1 | Alias Symbol: Klk6 | ||
| Type: protein-coding gene | Cytoband: 19q13.33 | ||
| Entrez ID: 3816 | HGNC ID: HGNC:6357 | Ensembl Gene: ENSG00000167748 | OMIM ID: 147910 |
| Drug and gene relationship at DGIdb | |||
KLK1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04961 | Endocrine and other factor-regulated calcium reabsorption |
Expression of KLK1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KLK1 | 3816 | 216699_s_at | -0.2018 | 0.5347 | |
| GSE20347 | KLK1 | 3816 | 216699_s_at | -0.2140 | 0.0744 | |
| GSE23400 | KLK1 | 3816 | 216699_s_at | -0.1574 | 0.0018 | |
| GSE26886 | KLK1 | 3816 | 216699_s_at | 0.4333 | 0.0037 | |
| GSE29001 | KLK1 | 3816 | 216699_s_at | -0.2405 | 0.2171 | |
| GSE38129 | KLK1 | 3816 | 216699_s_at | -0.0980 | 0.4464 | |
| GSE45670 | KLK1 | 3816 | 216699_s_at | 0.2254 | 0.0711 | |
| GSE53622 | KLK1 | 3816 | 55558 | -0.0984 | 0.7088 | |
| GSE53624 | KLK1 | 3816 | 55558 | -0.0335 | 0.8561 | |
| GSE63941 | KLK1 | 3816 | 216699_s_at | 0.4545 | 0.0160 | |
| GSE77861 | KLK1 | 3816 | 216699_s_at | 0.0467 | 0.8533 | |
| GSE97050 | KLK1 | 3816 | A_23_P16252 | 0.4284 | 0.3156 | |
| SRP064894 | KLK1 | 3816 | RNAseq | 0.0071 | 0.9884 | |
| SRP159526 | KLK1 | 3816 | RNAseq | -0.4127 | 0.6501 | |
| TCGA | KLK1 | 3816 | RNAseq | -0.0205 | 0.9564 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by KLK1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KLK1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KLK1 | 3816 | 3 | 4 | 23 | |
| GSE20123 | KLK1 | 3816 | 3 | 3 | 24 | |
| GSE43470 | KLK1 | 3816 | 4 | 11 | 28 | |
| GSE46452 | KLK1 | 3816 | 45 | 1 | 13 | |
| GSE47630 | KLK1 | 3816 | 9 | 6 | 25 | |
| GSE54993 | KLK1 | 3816 | 17 | 4 | 49 | |
| GSE54994 | KLK1 | 3816 | 4 | 14 | 35 | |
| GSE60625 | KLK1 | 3816 | 9 | 0 | 2 | |
| GSE74703 | KLK1 | 3816 | 4 | 7 | 25 | |
| GSE74704 | KLK1 | 3816 | 3 | 1 | 16 | |
| TCGA | KLK1 | 3816 | 14 | 19 | 63 |
Total number of gains: 115; Total number of losses: 70; Total Number of normals: 303.
Somatic mutations of KLK1:
Generating mutation plots.
Highly correlated genes for KLK1:
Showing top 20/394 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KLK1 | TSNAXIP1 | 0.703129 | 3 | 0 | 3 |
| KLK1 | FRS3 | 0.694124 | 3 | 0 | 3 |
| KLK1 | ABCA4 | 0.693112 | 3 | 0 | 3 |
| KLK1 | VWA5B1 | 0.677132 | 3 | 0 | 3 |
| KLK1 | TFF1 | 0.674994 | 3 | 0 | 3 |
| KLK1 | JSRP1 | 0.672229 | 3 | 0 | 3 |
| KLK1 | MAPK15 | 0.664387 | 4 | 0 | 3 |
| KLK1 | TOR2A | 0.663956 | 4 | 0 | 4 |
| KLK1 | LRFN2 | 0.65785 | 3 | 0 | 3 |
| KLK1 | FFAR1 | 0.656505 | 4 | 0 | 3 |
| KLK1 | NTNG2 | 0.654607 | 3 | 0 | 3 |
| KLK1 | FOXB1 | 0.651837 | 5 | 0 | 5 |
| KLK1 | NPBWR1 | 0.648337 | 3 | 0 | 3 |
| KLK1 | CACNA1A | 0.647661 | 6 | 0 | 5 |
| KLK1 | IER5L | 0.640513 | 3 | 0 | 3 |
| KLK1 | WAS | 0.635913 | 3 | 0 | 3 |
| KLK1 | WNT9A | 0.631257 | 5 | 0 | 4 |
| KLK1 | FAM181A | 0.629176 | 3 | 0 | 3 |
| KLK1 | ASCL5 | 0.627487 | 3 | 0 | 3 |
| KLK1 | CNTD2 | 0.624991 | 5 | 0 | 4 |
For details and further investigation, click here
