| Full name: transmembrane channel like 5 | Alias Symbol: FLJ13593 | ||
| Type: protein-coding gene | Cytoband: 16p12.3 | ||
| Entrez ID: 79838 | HGNC ID: HGNC:22999 | Ensembl Gene: ENSG00000103534 | OMIM ID: 617197 |
| Drug and gene relationship at DGIdb | |||
Expression of TMC5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE20347 | TMC5 | 79838 | 219580_s_at | -0.2647 | 0.1565 | |
| GSE23400 | TMC5 | 79838 | 219580_s_at | -0.1416 | 0.0148 | |
| GSE26886 | TMC5 | 79838 | 222904_s_at | -0.7353 | 0.1346 | |
| GSE29001 | TMC5 | 79838 | 219580_s_at | -0.3687 | 0.2304 | |
| GSE38129 | TMC5 | 79838 | 219580_s_at | -0.2062 | 0.4331 | |
| GSE53622 | TMC5 | 79838 | 38353 | -1.1789 | 0.0013 | |
| GSE53624 | TMC5 | 79838 | 38353 | -1.3797 | 0.0000 | |
| GSE77861 | TMC5 | 79838 | 240303_at | -0.2134 | 0.1567 | |
| GSE97050 | TMC5 | 79838 | A_23_P15101 | 0.8548 | 0.4170 | |
| SRP064894 | TMC5 | 79838 | RNAseq | -0.7702 | 0.1681 | |
| SRP133303 | TMC5 | 79838 | RNAseq | -0.4817 | 0.4612 | |
| SRP159526 | TMC5 | 79838 | RNAseq | -1.5500 | 0.0556 | |
| SRP193095 | TMC5 | 79838 | RNAseq | -0.6289 | 0.3054 | |
| SRP219564 | TMC5 | 79838 | RNAseq | 0.0205 | 0.9769 | |
| TCGA | TMC5 | 79838 | RNAseq | -1.5394 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by TMC5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TMC5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TMC5 | 79838 | 6 | 3 | 21 | |
| GSE20123 | TMC5 | 79838 | 6 | 2 | 22 | |
| GSE43470 | TMC5 | 79838 | 3 | 3 | 37 | |
| GSE46452 | TMC5 | 79838 | 38 | 1 | 20 | |
| GSE47630 | TMC5 | 79838 | 11 | 6 | 23 | |
| GSE54993 | TMC5 | 79838 | 3 | 5 | 62 | |
| GSE54994 | TMC5 | 79838 | 3 | 10 | 40 | |
| GSE60625 | TMC5 | 79838 | 4 | 0 | 7 | |
| GSE74703 | TMC5 | 79838 | 3 | 2 | 31 | |
| GSE74704 | TMC5 | 79838 | 3 | 1 | 16 | |
| TCGA | TMC5 | 79838 | 21 | 12 | 63 |
Total number of gains: 101; Total number of losses: 45; Total Number of normals: 342.
Somatic mutations of TMC5:
Generating mutation plots.
Highly correlated genes for TMC5:
Showing top 20/45 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TMC5 | TOX3 | 0.693495 | 5 | 0 | 5 |
| TMC5 | KLRC3 | 0.690283 | 3 | 0 | 3 |
| TMC5 | SLC44A4 | 0.642638 | 7 | 0 | 5 |
| TMC5 | LDHD | 0.628906 | 4 | 0 | 3 |
| TMC5 | SLC25A10 | 0.62144 | 4 | 0 | 3 |
| TMC5 | PLIN5 | 0.614051 | 4 | 0 | 3 |
| TMC5 | HSBP1 | 0.613961 | 3 | 0 | 3 |
| TMC5 | TFF2 | 0.613475 | 5 | 0 | 4 |
| TMC5 | LRG1 | 0.612404 | 5 | 0 | 4 |
| TMC5 | TSPAN8 | 0.610436 | 7 | 0 | 6 |
| TMC5 | MLPH | 0.593743 | 6 | 0 | 5 |
| TMC5 | VPS9D1 | 0.588885 | 3 | 0 | 3 |
| TMC5 | CLDN18 | 0.586017 | 4 | 0 | 3 |
| TMC5 | SERPINI2 | 0.577652 | 3 | 0 | 3 |
| TMC5 | RNF183 | 0.577225 | 5 | 0 | 3 |
| TMC5 | AGR2 | 0.573304 | 7 | 0 | 4 |
| TMC5 | SLC6A14 | 0.572129 | 4 | 0 | 3 |
| TMC5 | PROM1 | 0.571098 | 4 | 0 | 4 |
| TMC5 | GSTT2 | 0.568201 | 3 | 0 | 3 |
| TMC5 | GJB1 | 0.567481 | 3 | 0 | 3 |
For details and further investigation, click here
