| Full name: karyopherin subunit beta 1 | Alias Symbol: NTF97|IPOB|MGC2155|MGC2156|MGC2157|IMB1|Impnb|IPO1 | ||
| Type: protein-coding gene | Cytoband: 17q21.32 | ||
| Entrez ID: 3837 | HGNC ID: HGNC:6400 | Ensembl Gene: ENSG00000108424 | OMIM ID: 602738 |
| Drug and gene relationship at DGIdb | |||
Expression of KPNB1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KPNB1 | 3837 | 213507_s_at | 0.5275 | 0.0369 | |
| GSE20347 | KPNB1 | 3837 | 213507_s_at | 0.3243 | 0.0005 | |
| GSE23400 | KPNB1 | 3837 | 213507_s_at | 0.3363 | 0.0000 | |
| GSE26886 | KPNB1 | 3837 | 213507_s_at | 0.0558 | 0.7697 | |
| GSE29001 | KPNB1 | 3837 | 213507_s_at | 0.1406 | 0.4811 | |
| GSE38129 | KPNB1 | 3837 | 213507_s_at | 0.3570 | 0.0000 | |
| GSE45670 | KPNB1 | 3837 | 213507_s_at | 0.1966 | 0.0462 | |
| GSE53622 | KPNB1 | 3837 | 77259 | 0.0589 | 0.2598 | |
| GSE53624 | KPNB1 | 3837 | 77259 | 0.2611 | 0.0000 | |
| GSE63941 | KPNB1 | 3837 | 213507_s_at | -0.3689 | 0.2407 | |
| GSE77861 | KPNB1 | 3837 | 213507_s_at | 0.3252 | 0.0245 | |
| GSE97050 | KPNB1 | 3837 | A_32_P184727 | 0.1304 | 0.6211 | |
| SRP007169 | KPNB1 | 3837 | RNAseq | 0.6222 | 0.0714 | |
| SRP008496 | KPNB1 | 3837 | RNAseq | 0.4551 | 0.0320 | |
| SRP064894 | KPNB1 | 3837 | RNAseq | 0.1611 | 0.3389 | |
| SRP133303 | KPNB1 | 3837 | RNAseq | 0.1916 | 0.0480 | |
| SRP159526 | KPNB1 | 3837 | RNAseq | 0.1536 | 0.2393 | |
| SRP193095 | KPNB1 | 3837 | RNAseq | 0.0157 | 0.8529 | |
| SRP219564 | KPNB1 | 3837 | RNAseq | 0.1885 | 0.5670 | |
| TCGA | KPNB1 | 3837 | RNAseq | 0.0797 | 0.0417 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by KPNB1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KPNB1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KPNB1 | 3837 | 5 | 2 | 23 | |
| GSE20123 | KPNB1 | 3837 | 5 | 2 | 23 | |
| GSE43470 | KPNB1 | 3837 | 1 | 2 | 40 | |
| GSE46452 | KPNB1 | 3837 | 32 | 0 | 27 | |
| GSE47630 | KPNB1 | 3837 | 9 | 0 | 31 | |
| GSE54993 | KPNB1 | 3837 | 2 | 4 | 64 | |
| GSE54994 | KPNB1 | 3837 | 11 | 5 | 37 | |
| GSE60625 | KPNB1 | 3837 | 4 | 0 | 7 | |
| GSE74703 | KPNB1 | 3837 | 1 | 1 | 34 | |
| GSE74704 | KPNB1 | 3837 | 4 | 1 | 15 | |
| TCGA | KPNB1 | 3837 | 27 | 6 | 63 |
Total number of gains: 101; Total number of losses: 23; Total Number of normals: 364.
Somatic mutations of KPNB1:
Generating mutation plots.
Highly correlated genes for KPNB1:
Showing top 20/900 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KPNB1 | YY1 | 0.768 | 3 | 0 | 3 |
| KPNB1 | PEX13 | 0.751229 | 3 | 0 | 3 |
| KPNB1 | ZNF496 | 0.736677 | 3 | 0 | 3 |
| KPNB1 | CLPTM1L | 0.73659 | 3 | 0 | 3 |
| KPNB1 | KLHL8 | 0.734173 | 3 | 0 | 3 |
| KPNB1 | ZNF668 | 0.724514 | 3 | 0 | 3 |
| KPNB1 | ARFRP1 | 0.719689 | 3 | 0 | 3 |
| KPNB1 | SLC41A1 | 0.717895 | 3 | 0 | 3 |
| KPNB1 | KCTD15 | 0.704892 | 3 | 0 | 3 |
| KPNB1 | ZSCAN21 | 0.701124 | 3 | 0 | 3 |
| KPNB1 | CCDC14 | 0.699442 | 4 | 0 | 3 |
| KPNB1 | XXYLT1 | 0.693759 | 3 | 0 | 3 |
| KPNB1 | PTP4A2 | 0.688303 | 4 | 0 | 3 |
| KPNB1 | NACC1 | 0.676264 | 4 | 0 | 3 |
| KPNB1 | LRRC58 | 0.673099 | 4 | 0 | 3 |
| KPNB1 | FOXK2 | 0.671348 | 8 | 0 | 6 |
| KPNB1 | G2E3 | 0.666117 | 4 | 0 | 4 |
| KPNB1 | YWHAG | 0.664678 | 6 | 0 | 5 |
| KPNB1 | MRPS5 | 0.663413 | 5 | 0 | 4 |
| KPNB1 | PUF60 | 0.661658 | 7 | 0 | 7 |
For details and further investigation, click here
