| Full name: kelch like family member 8 | Alias Symbol: KIAA1378 | ||
| Type: protein-coding gene | Cytoband: 4q22.1 | ||
| Entrez ID: 57563 | HGNC ID: HGNC:18644 | Ensembl Gene: ENSG00000145332 | OMIM ID: 611967 |
| Drug and gene relationship at DGIdb | |||
Expression of KLHL8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KLHL8 | 57563 | 242648_at | 0.7810 | 0.0702 | |
| GSE26886 | KLHL8 | 57563 | 226874_at | 0.2163 | 0.3299 | |
| GSE45670 | KLHL8 | 57563 | 242648_at | 0.0573 | 0.7562 | |
| GSE53622 | KLHL8 | 57563 | 71294 | 0.1580 | 0.0073 | |
| GSE53624 | KLHL8 | 57563 | 71294 | 0.2191 | 0.0010 | |
| GSE63941 | KLHL8 | 57563 | 242648_at | -0.3591 | 0.4031 | |
| GSE77861 | KLHL8 | 57563 | 242648_at | 0.1730 | 0.5128 | |
| GSE97050 | KLHL8 | 57563 | A_24_P54808 | -0.1382 | 0.5138 | |
| SRP007169 | KLHL8 | 57563 | RNAseq | 0.5854 | 0.1647 | |
| SRP008496 | KLHL8 | 57563 | RNAseq | 0.9184 | 0.0005 | |
| SRP064894 | KLHL8 | 57563 | RNAseq | 0.2330 | 0.1835 | |
| SRP133303 | KLHL8 | 57563 | RNAseq | 0.3546 | 0.0300 | |
| SRP159526 | KLHL8 | 57563 | RNAseq | 0.4507 | 0.0333 | |
| SRP193095 | KLHL8 | 57563 | RNAseq | -0.0550 | 0.5593 | |
| SRP219564 | KLHL8 | 57563 | RNAseq | 0.3528 | 0.1962 | |
| TCGA | KLHL8 | 57563 | RNAseq | -0.0498 | 0.4117 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by KLHL8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KLHL8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KLHL8 | 57563 | 3 | 12 | 15 | |
| GSE20123 | KLHL8 | 57563 | 3 | 12 | 15 | |
| GSE43470 | KLHL8 | 57563 | 0 | 13 | 30 | |
| GSE46452 | KLHL8 | 57563 | 2 | 35 | 22 | |
| GSE47630 | KLHL8 | 57563 | 0 | 20 | 20 | |
| GSE54993 | KLHL8 | 57563 | 8 | 0 | 62 | |
| GSE54994 | KLHL8 | 57563 | 1 | 9 | 43 | |
| GSE60625 | KLHL8 | 57563 | 0 | 0 | 11 | |
| GSE74703 | KLHL8 | 57563 | 0 | 11 | 25 | |
| GSE74704 | KLHL8 | 57563 | 2 | 7 | 11 | |
| TCGA | KLHL8 | 57563 | 12 | 36 | 48 |
Total number of gains: 31; Total number of losses: 155; Total Number of normals: 302.
Somatic mutations of KLHL8:
Generating mutation plots.
Highly correlated genes for KLHL8:
Showing top 20/232 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KLHL8 | SPATA2 | 0.846078 | 3 | 0 | 3 |
| KLHL8 | POLR2K | 0.820212 | 3 | 0 | 3 |
| KLHL8 | ALMS1 | 0.763008 | 3 | 0 | 3 |
| KLHL8 | CELF1 | 0.759598 | 3 | 0 | 3 |
| KLHL8 | KBTBD7 | 0.759371 | 3 | 0 | 3 |
| KLHL8 | RBM26 | 0.753193 | 3 | 0 | 3 |
| KLHL8 | SLC39A10 | 0.752306 | 3 | 0 | 3 |
| KLHL8 | RBM34 | 0.751527 | 3 | 0 | 3 |
| KLHL8 | PIGU | 0.747577 | 3 | 0 | 3 |
| KLHL8 | NUP43 | 0.746916 | 4 | 0 | 4 |
| KLHL8 | BPNT1 | 0.742018 | 3 | 0 | 3 |
| KLHL8 | ZNF557 | 0.739167 | 3 | 0 | 3 |
| KLHL8 | POLR3F | 0.738921 | 3 | 0 | 3 |
| KLHL8 | CHML | 0.736435 | 3 | 0 | 3 |
| KLHL8 | KPNB1 | 0.734173 | 3 | 0 | 3 |
| KLHL8 | ADO | 0.728587 | 3 | 0 | 3 |
| KLHL8 | FNBP1L | 0.727948 | 3 | 0 | 3 |
| KLHL8 | ZNF184 | 0.726875 | 3 | 0 | 3 |
| KLHL8 | NDUFS2 | 0.722545 | 3 | 0 | 3 |
| KLHL8 | AGMAT | 0.714397 | 3 | 0 | 3 |
For details and further investigation, click here
