| Full name: protein tyrosine phosphatase 4A2 | Alias Symbol: HU-PP-1|PTPCAAX2|OV-1|ptp-IV1a|PRL-2|PRL2 | ||
| Type: protein-coding gene | Cytoband: 1p35.2 | ||
| Entrez ID: 8073 | HGNC ID: HGNC:9635 | Ensembl Gene: ENSG00000184007 | OMIM ID: 601584 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of PTP4A2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PTP4A2 | 8073 | 208616_s_at | 0.0688 | 0.8352 | |
| GSE20347 | PTP4A2 | 8073 | 208616_s_at | 0.3212 | 0.0034 | |
| GSE23400 | PTP4A2 | 8073 | 208616_s_at | 0.3280 | 0.0000 | |
| GSE26886 | PTP4A2 | 8073 | 208616_s_at | 0.3604 | 0.0630 | |
| GSE29001 | PTP4A2 | 8073 | 208616_s_at | 0.4747 | 0.0626 | |
| GSE38129 | PTP4A2 | 8073 | 208616_s_at | 0.1789 | 0.1178 | |
| GSE45670 | PTP4A2 | 8073 | 208616_s_at | 0.3279 | 0.0068 | |
| GSE53622 | PTP4A2 | 8073 | 19149 | -0.1623 | 0.0081 | |
| GSE53624 | PTP4A2 | 8073 | 19149 | 0.1481 | 0.0117 | |
| GSE63941 | PTP4A2 | 8073 | 208616_s_at | -0.7749 | 0.0151 | |
| GSE77861 | PTP4A2 | 8073 | 208616_s_at | 0.2901 | 0.2172 | |
| GSE97050 | PTP4A2 | 8073 | A_23_P23114 | 0.0133 | 0.9738 | |
| SRP007169 | PTP4A2 | 8073 | RNAseq | 0.5849 | 0.1615 | |
| SRP008496 | PTP4A2 | 8073 | RNAseq | 0.6268 | 0.0029 | |
| SRP064894 | PTP4A2 | 8073 | RNAseq | 0.3345 | 0.0153 | |
| SRP133303 | PTP4A2 | 8073 | RNAseq | 0.4206 | 0.0022 | |
| SRP159526 | PTP4A2 | 8073 | RNAseq | 0.7511 | 0.1324 | |
| SRP193095 | PTP4A2 | 8073 | RNAseq | -0.1022 | 0.5188 | |
| SRP219564 | PTP4A2 | 8073 | RNAseq | -0.0208 | 0.9491 | |
| TCGA | PTP4A2 | 8073 | RNAseq | -0.1512 | 0.0006 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PTP4A2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PTP4A2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PTP4A2 | 8073 | 1 | 5 | 24 | |
| GSE20123 | PTP4A2 | 8073 | 1 | 4 | 25 | |
| GSE43470 | PTP4A2 | 8073 | 6 | 4 | 33 | |
| GSE46452 | PTP4A2 | 8073 | 5 | 1 | 53 | |
| GSE47630 | PTP4A2 | 8073 | 8 | 3 | 29 | |
| GSE54993 | PTP4A2 | 8073 | 1 | 1 | 68 | |
| GSE54994 | PTP4A2 | 8073 | 11 | 2 | 40 | |
| GSE60625 | PTP4A2 | 8073 | 0 | 0 | 11 | |
| GSE74703 | PTP4A2 | 8073 | 4 | 3 | 29 | |
| GSE74704 | PTP4A2 | 8073 | 0 | 0 | 20 | |
| TCGA | PTP4A2 | 8073 | 12 | 20 | 64 |
Total number of gains: 49; Total number of losses: 43; Total Number of normals: 396.
Somatic mutations of PTP4A2:
Generating mutation plots.
Highly correlated genes for PTP4A2:
Showing top 20/795 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PTP4A2 | ZNF407 | 0.749211 | 3 | 0 | 3 |
| PTP4A2 | OSGEP | 0.735437 | 3 | 0 | 3 |
| PTP4A2 | MED29 | 0.734766 | 3 | 0 | 3 |
| PTP4A2 | SFPQ | 0.734063 | 5 | 0 | 4 |
| PTP4A2 | GPR107 | 0.701865 | 4 | 0 | 3 |
| PTP4A2 | LRRC14 | 0.701445 | 4 | 0 | 4 |
| PTP4A2 | ZNF595 | 0.697196 | 3 | 0 | 3 |
| PTP4A2 | LIMS1 | 0.692328 | 3 | 0 | 3 |
| PTP4A2 | ZNF267 | 0.691953 | 3 | 0 | 3 |
| PTP4A2 | PTGFRN | 0.691189 | 4 | 0 | 3 |
| PTP4A2 | ZCCHC17 | 0.689226 | 6 | 0 | 5 |
| PTP4A2 | KPNB1 | 0.688303 | 4 | 0 | 3 |
| PTP4A2 | S1PR3 | 0.686443 | 3 | 0 | 3 |
| PTP4A2 | AP5S1 | 0.681618 | 3 | 0 | 3 |
| PTP4A2 | NR3C1 | 0.680044 | 4 | 0 | 3 |
| PTP4A2 | ELF4 | 0.678474 | 4 | 0 | 4 |
| PTP4A2 | RNF139 | 0.675204 | 4 | 0 | 3 |
| PTP4A2 | NCKIPSD | 0.672463 | 4 | 0 | 3 |
| PTP4A2 | TPCN2 | 0.668298 | 3 | 0 | 3 |
| PTP4A2 | TMEM208 | 0.667402 | 4 | 0 | 3 |
For details and further investigation, click here
