| Full name: low density lipoprotein receptor class A domain containing 3 | Alias Symbol: LRAD3 | ||
| Type: protein-coding gene | Cytoband: 11p13 | ||
| Entrez ID: 143458 | HGNC ID: HGNC:27046 | Ensembl Gene: ENSG00000179241 | OMIM ID: 617986 |
| Drug and gene relationship at DGIdb | |||
Expression of LDLRAD3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LDLRAD3 | 143458 | 234985_at | -0.0299 | 0.9822 | |
| GSE26886 | LDLRAD3 | 143458 | 234985_at | -0.1873 | 0.7248 | |
| GSE45670 | LDLRAD3 | 143458 | 234985_at | -0.2861 | 0.1688 | |
| GSE53622 | LDLRAD3 | 143458 | 136676 | -0.0295 | 0.8754 | |
| GSE53624 | LDLRAD3 | 143458 | 136676 | -0.1664 | 0.1504 | |
| GSE63941 | LDLRAD3 | 143458 | 234985_at | 0.0861 | 0.9314 | |
| GSE77861 | LDLRAD3 | 143458 | 234985_at | 0.0340 | 0.8361 | |
| GSE97050 | LDLRAD3 | 143458 | A_24_P391574 | -0.2051 | 0.6286 | |
| SRP007169 | LDLRAD3 | 143458 | RNAseq | -0.7044 | 0.1156 | |
| SRP008496 | LDLRAD3 | 143458 | RNAseq | -0.3303 | 0.2581 | |
| SRP064894 | LDLRAD3 | 143458 | RNAseq | 0.8798 | 0.0250 | |
| SRP133303 | LDLRAD3 | 143458 | RNAseq | -0.1949 | 0.4214 | |
| SRP159526 | LDLRAD3 | 143458 | RNAseq | 0.5046 | 0.3103 | |
| SRP193095 | LDLRAD3 | 143458 | RNAseq | -0.2679 | 0.1992 | |
| SRP219564 | LDLRAD3 | 143458 | RNAseq | 0.5636 | 0.2946 | |
| TCGA | LDLRAD3 | 143458 | RNAseq | 0.4140 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by LDLRAD3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LDLRAD3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LDLRAD3 | 143458 | 0 | 8 | 22 | |
| GSE20123 | LDLRAD3 | 143458 | 0 | 7 | 23 | |
| GSE43470 | LDLRAD3 | 143458 | 3 | 4 | 36 | |
| GSE46452 | LDLRAD3 | 143458 | 7 | 5 | 47 | |
| GSE47630 | LDLRAD3 | 143458 | 3 | 10 | 27 | |
| GSE54993 | LDLRAD3 | 143458 | 3 | 2 | 65 | |
| GSE54994 | LDLRAD3 | 143458 | 3 | 10 | 40 | |
| GSE60625 | LDLRAD3 | 143458 | 0 | 0 | 11 | |
| GSE74703 | LDLRAD3 | 143458 | 2 | 2 | 32 | |
| GSE74704 | LDLRAD3 | 143458 | 0 | 5 | 15 | |
| TCGA | LDLRAD3 | 143458 | 13 | 23 | 60 |
Total number of gains: 34; Total number of losses: 76; Total Number of normals: 378.
Somatic mutations of LDLRAD3:
Generating mutation plots.
Highly correlated genes for LDLRAD3:
Showing top 20/88 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LDLRAD3 | CD44 | 0.733097 | 3 | 0 | 3 |
| LDLRAD3 | OPTN | 0.723243 | 3 | 0 | 3 |
| LDLRAD3 | ZNF638 | 0.722706 | 3 | 0 | 3 |
| LDLRAD3 | IL6R | 0.710744 | 3 | 0 | 3 |
| LDLRAD3 | PRSS12 | 0.699821 | 3 | 0 | 3 |
| LDLRAD3 | MEGF6 | 0.696239 | 3 | 0 | 3 |
| LDLRAD3 | SLC22A5 | 0.695883 | 3 | 0 | 3 |
| LDLRAD3 | PLD2 | 0.693333 | 3 | 0 | 3 |
| LDLRAD3 | CREG1 | 0.692501 | 3 | 0 | 3 |
| LDLRAD3 | METTL15 | 0.685057 | 4 | 0 | 3 |
| LDLRAD3 | GNAI1 | 0.679661 | 3 | 0 | 3 |
| LDLRAD3 | FOPNL | 0.678587 | 3 | 0 | 3 |
| LDLRAD3 | CD82 | 0.677998 | 4 | 0 | 4 |
| LDLRAD3 | EXT2 | 0.675568 | 3 | 0 | 3 |
| LDLRAD3 | PSMD12 | 0.665901 | 3 | 0 | 3 |
| LDLRAD3 | GPCPD1 | 0.664953 | 3 | 0 | 3 |
| LDLRAD3 | TULP4 | 0.655833 | 3 | 0 | 3 |
| LDLRAD3 | DPY19L3 | 0.653466 | 3 | 0 | 3 |
| LDLRAD3 | SPAG9 | 0.649278 | 3 | 0 | 3 |
| LDLRAD3 | YWHAE | 0.648122 | 3 | 0 | 3 |
For details and further investigation, click here
