GNAI1

 

Full name: G protein subunit alpha i1 Alias Symbol: 
Type: protein-coding gene Cytoband: 7q21.11
Entrez ID: 2770 HGNC ID: HGNC:4384 Ensembl Gene: ENSG00000127955 OMIM ID: 139310
Drug and gene relationship at DGIdb

 

GNAI1 involved pathways:

KEGG pathway Description View
hsa04015Rap1 signaling pathway
hsa04022cGMP-PKG signaling pathway
hsa04024cAMP signaling pathway
hsa04062Chemokine signaling pathway
hsa04071Sphingolipid signaling pathway
hsa04261Adrenergic signaling in cardiomyocytes
hsa04360Axon guidance
hsa04540Gap junction
hsa04611Platelet activation
hsa04670Leukocyte transendothelial migration
hsa04713Circadian entrainment
hsa04723Retrograde endocannabinoid signaling
hsa04724Glutamatergic synapse
hsa04725Cholinergic synapse
hsa04726Serotonergic synapse
hsa04727GABAergic synapse
hsa04728Dopaminergic synapse
hsa04730Long-term depression
hsa04914Progesterone-mediated oocyte maturation
hsa04915Estrogen signaling pathway
hsa04916Melanogenesis
hsa04921Oxytocin signaling pathway
hsa04923Regulation of lipolysis in adipocytes
hsa04924Renin secretion
hsa04971Gastric acid secretion
hsa05012Parkinson's disease
hsa05030Cocaine addiction
hsa05032Morphine addiction
hsa05034Alcoholism
hsa05133Pertussis
hsa05142Chagas disease (American trypanosomiasis)
hsa05145Toxoplasmosis

 

Expression of GNAI1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 GNAI1 2770 227692_at -0.3008 0.6676
GSE20347 GNAI1 2770 209576_at 0.1327 0.7794
GSE23400 GNAI1 2770 209576_at 0.6466 0.0000
GSE26886 GNAI1 2770 227692_at -0.2885 0.2860
GSE29001 GNAI1 2770 209576_at 0.7187 0.1015
GSE38129 GNAI1 2770 209576_at 0.1634 0.5893
GSE45670 GNAI1 2770 227692_at 0.0123 0.9617
GSE53622 GNAI1 2770 72635 -0.2442 0.0133
GSE53624 GNAI1 2770 72635 -0.1080 0.1691
GSE63941 GNAI1 2770 227692_at -1.1532 0.1959
GSE77861 GNAI1 2770 227692_at 0.4241 0.2995
GSE97050 GNAI1 2770 A_23_P122976 -0.4522 0.2764
SRP007169 GNAI1 2770 RNAseq 0.5509 0.2813
SRP008496 GNAI1 2770 RNAseq 0.5753 0.0482
SRP064894 GNAI1 2770 RNAseq 0.1199 0.6374
SRP133303 GNAI1 2770 RNAseq 0.4482 0.0812
SRP159526 GNAI1 2770 RNAseq -0.3637 0.2758
SRP193095 GNAI1 2770 RNAseq 0.5565 0.0028
SRP219564 GNAI1 2770 RNAseq 0.2777 0.5593
TCGA GNAI1 2770 RNAseq 0.0832 0.2637

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by GNAI1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of GNAI1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 GNAI1 2770 13 1 16
GSE20123 GNAI1 2770 12 1 17
GSE43470 GNAI1 2770 4 1 38
GSE46452 GNAI1 2770 11 0 48
GSE47630 GNAI1 2770 7 3 30
GSE54993 GNAI1 2770 1 7 62
GSE54994 GNAI1 2770 16 3 34
GSE60625 GNAI1 2770 0 0 11
GSE74703 GNAI1 2770 3 1 32
GSE74704 GNAI1 2770 8 1 11
TCGA GNAI1 2770 46 5 45

Total number of gains: 121; Total number of losses: 23; Total Number of normals: 344.  

 

Somatic mutations of GNAI1:

 

Generating mutation plots.

 

Highly correlated genes for GNAI1:

 

Showing top 20/250 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
GNAI1PARP20.812569303
GNAI1THOC10.788207303
GNAI1TGOLN20.776454303
GNAI1RRP150.754548303
GNAI1SKA20.7431303
GNAI1LIN520.731631303
GNAI1ERVW-10.699341303
GNAI1KRR10.695621303
GNAI1UBE2Q20.691459403
GNAI1THAP100.686662303
GNAI1EIF1B0.6823403
GNAI1LDLRAD30.679661303
GNAI1PSMD70.675769403
GNAI1DYRK20.674539403
GNAI1CCDC510.66803403
GNAI1INVS0.667466303
GNAI1THUMPD30.666286403
GNAI1CBLL10.666024403
GNAI1COMMD100.66581404
GNAI1UBE2E20.66282403

For details and further investigation, click here