| Full name: galectin 3 | Alias Symbol: MAC-2|GALIG | ||
| Type: protein-coding gene | Cytoband: 14q22.3 | ||
| Entrez ID: 3958 | HGNC ID: HGNC:6563 | Ensembl Gene: ENSG00000131981 | OMIM ID: 153619 |
| Drug and gene relationship at DGIdb | |||
Expression of LGALS3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LGALS3 | 3958 | 208949_s_at | -0.5912 | 0.1718 | |
| GSE20347 | LGALS3 | 3958 | 208949_s_at | -1.1167 | 0.0000 | |
| GSE23400 | LGALS3 | 3958 | 208949_s_at | -0.9306 | 0.0000 | |
| GSE26886 | LGALS3 | 3958 | 208949_s_at | -1.2496 | 0.0000 | |
| GSE29001 | LGALS3 | 3958 | 208949_s_at | -0.7935 | 0.0073 | |
| GSE38129 | LGALS3 | 3958 | 208949_s_at | -0.9392 | 0.0000 | |
| GSE45670 | LGALS3 | 3958 | 208949_s_at | -0.5425 | 0.0007 | |
| GSE53622 | LGALS3 | 3958 | 91371 | -1.2797 | 0.0000 | |
| GSE53624 | LGALS3 | 3958 | 91371 | -1.2435 | 0.0000 | |
| GSE63941 | LGALS3 | 3958 | 208949_s_at | -0.8946 | 0.1746 | |
| GSE77861 | LGALS3 | 3958 | 208949_s_at | -0.4758 | 0.1370 | |
| GSE97050 | LGALS3 | 3958 | A_23_P128919 | -0.6897 | 0.1279 | |
| SRP007169 | LGALS3 | 3958 | RNAseq | -3.3888 | 0.0000 | |
| SRP008496 | LGALS3 | 3958 | RNAseq | -3.1168 | 0.0000 | |
| SRP064894 | LGALS3 | 3958 | RNAseq | -1.7228 | 0.0000 | |
| SRP133303 | LGALS3 | 3958 | RNAseq | -1.2384 | 0.0000 | |
| SRP159526 | LGALS3 | 3958 | RNAseq | -2.3344 | 0.0000 | |
| SRP193095 | LGALS3 | 3958 | RNAseq | -1.9738 | 0.0000 | |
| SRP219564 | LGALS3 | 3958 | RNAseq | -1.0257 | 0.0549 | |
| TCGA | LGALS3 | 3958 | RNAseq | -0.1764 | 0.0147 |
Upregulated datasets: 0; Downregulated datasets: 10.
Survival by LGALS3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LGALS3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LGALS3 | 3958 | 8 | 3 | 19 | |
| GSE20123 | LGALS3 | 3958 | 8 | 3 | 19 | |
| GSE43470 | LGALS3 | 3958 | 9 | 1 | 33 | |
| GSE46452 | LGALS3 | 3958 | 16 | 3 | 40 | |
| GSE47630 | LGALS3 | 3958 | 11 | 10 | 19 | |
| GSE54993 | LGALS3 | 3958 | 3 | 8 | 59 | |
| GSE54994 | LGALS3 | 3958 | 19 | 4 | 30 | |
| GSE60625 | LGALS3 | 3958 | 0 | 2 | 9 | |
| GSE74703 | LGALS3 | 3958 | 8 | 1 | 27 | |
| GSE74704 | LGALS3 | 3958 | 3 | 2 | 15 | |
| TCGA | LGALS3 | 3958 | 33 | 14 | 49 |
Total number of gains: 118; Total number of losses: 51; Total Number of normals: 319.
Somatic mutations of LGALS3:
Generating mutation plots.
Highly correlated genes for LGALS3:
Showing top 20/861 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LGALS3 | NCCRP1 | 0.782875 | 3 | 0 | 3 |
| LGALS3 | IL18 | 0.775209 | 10 | 0 | 10 |
| LGALS3 | NCR1 | 0.773906 | 3 | 0 | 3 |
| LGALS3 | EMP1 | 0.770386 | 10 | 0 | 10 |
| LGALS3 | MUC22 | 0.765694 | 3 | 0 | 3 |
| LGALS3 | PTK6 | 0.762617 | 10 | 0 | 10 |
| LGALS3 | GPX6 | 0.7624 | 3 | 0 | 3 |
| LGALS3 | FAM163B | 0.758695 | 3 | 0 | 3 |
| LGALS3 | MAL | 0.756177 | 10 | 0 | 10 |
| LGALS3 | CYSRT1 | 0.753532 | 5 | 0 | 5 |
| LGALS3 | SDCBP2 | 0.753471 | 3 | 0 | 3 |
| LGALS3 | AHNAK | 0.751533 | 12 | 0 | 12 |
| LGALS3 | KRT4 | 0.751219 | 10 | 0 | 10 |
| LGALS3 | SLURP1 | 0.751092 | 10 | 0 | 10 |
| LGALS3 | SCEL | 0.750132 | 10 | 0 | 10 |
| LGALS3 | SMIM5 | 0.747706 | 5 | 0 | 5 |
| LGALS3 | NANOS2 | 0.739908 | 3 | 0 | 3 |
| LGALS3 | PPL | 0.739856 | 10 | 0 | 10 |
| LGALS3 | VSIG10L | 0.738687 | 6 | 0 | 6 |
| LGALS3 | C5orf66-AS1 | 0.738471 | 5 | 0 | 5 |
For details and further investigation, click here
