| Full name: keratin 4 | Alias Symbol: CK4|K4 | ||
| Type: protein-coding gene | Cytoband: 12q13.13 | ||
| Entrez ID: 3851 | HGNC ID: HGNC:6441 | Ensembl Gene: ENSG00000170477 | OMIM ID: 123940 |
| Drug and gene relationship at DGIdb | |||
Expression of KRT4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KRT4 | 3851 | 213240_s_at | -3.7617 | 0.0442 | |
| GSE20347 | KRT4 | 3851 | 213240_s_at | -4.9758 | 0.0000 | |
| GSE23400 | KRT4 | 3851 | 213240_s_at | -3.2212 | 0.0000 | |
| GSE26886 | KRT4 | 3851 | 213240_s_at | -8.0223 | 0.0000 | |
| GSE29001 | KRT4 | 3851 | 213240_s_at | -4.9837 | 0.0000 | |
| GSE38129 | KRT4 | 3851 | 213240_s_at | -3.6942 | 0.0001 | |
| GSE45670 | KRT4 | 3851 | 213240_s_at | -2.1831 | 0.0268 | |
| GSE53622 | KRT4 | 3851 | 62197 | -4.0130 | 0.0000 | |
| GSE53624 | KRT4 | 3851 | 62197 | -4.3284 | 0.0000 | |
| GSE63941 | KRT4 | 3851 | 213240_s_at | 3.0030 | 0.2189 | |
| GSE77861 | KRT4 | 3851 | 213240_s_at | -3.6932 | 0.0682 | |
| GSE97050 | KRT4 | 3851 | A_23_P2674 | -4.0498 | 0.0454 | |
| SRP007169 | KRT4 | 3851 | RNAseq | -11.0186 | 0.0000 | |
| SRP008496 | KRT4 | 3851 | RNAseq | -8.4584 | 0.0000 | |
| SRP064894 | KRT4 | 3851 | RNAseq | -5.0741 | 0.0000 | |
| SRP133303 | KRT4 | 3851 | RNAseq | -8.2770 | 0.0000 | |
| SRP159526 | KRT4 | 3851 | RNAseq | -7.7931 | 0.0000 | |
| SRP219564 | KRT4 | 3851 | RNAseq | -5.7602 | 0.0002 | |
| TCGA | KRT4 | 3851 | RNAseq | -0.3443 | 0.5923 |
Upregulated datasets: 0; Downregulated datasets: 16.
Survival by KRT4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KRT4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KRT4 | 3851 | 8 | 1 | 21 | |
| GSE20123 | KRT4 | 3851 | 8 | 1 | 21 | |
| GSE43470 | KRT4 | 3851 | 3 | 0 | 40 | |
| GSE46452 | KRT4 | 3851 | 7 | 1 | 51 | |
| GSE47630 | KRT4 | 3851 | 10 | 2 | 28 | |
| GSE54993 | KRT4 | 3851 | 0 | 5 | 65 | |
| GSE54994 | KRT4 | 3851 | 4 | 1 | 48 | |
| GSE60625 | KRT4 | 3851 | 0 | 0 | 11 | |
| GSE74703 | KRT4 | 3851 | 3 | 0 | 33 | |
| GSE74704 | KRT4 | 3851 | 5 | 1 | 14 | |
| TCGA | KRT4 | 3851 | 13 | 11 | 72 |
Total number of gains: 61; Total number of losses: 23; Total Number of normals: 404.
Somatic mutations of KRT4:
Generating mutation plots.
Highly correlated genes for KRT4:
Showing top 20/1216 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KRT4 | CRNN | 0.910204 | 12 | 0 | 12 |
| KRT4 | MAL | 0.904926 | 12 | 0 | 12 |
| KRT4 | SPINK5 | 0.882447 | 12 | 0 | 12 |
| KRT4 | TMPRSS11B | 0.874056 | 8 | 0 | 8 |
| KRT4 | C5orf66-AS1 | 0.874048 | 6 | 0 | 6 |
| KRT4 | CLCA4 | 0.873735 | 13 | 0 | 13 |
| KRT4 | KRT13 | 0.87363 | 13 | 0 | 13 |
| KRT4 | NCR1 | 0.873274 | 3 | 0 | 3 |
| KRT4 | EMP1 | 0.865801 | 12 | 0 | 12 |
| KRT4 | CYSRT1 | 0.861011 | 6 | 0 | 6 |
| KRT4 | MUC21 | 0.857735 | 3 | 0 | 3 |
| KRT4 | TGM3 | 0.852085 | 12 | 0 | 11 |
| KRT4 | PRSS27 | 0.846151 | 8 | 0 | 8 |
| KRT4 | SPRR3 | 0.842677 | 12 | 0 | 12 |
| KRT4 | CAPN14 | 0.83489 | 7 | 0 | 7 |
| KRT4 | SPINK7 | 0.833444 | 8 | 0 | 8 |
| KRT4 | FAM214A | 0.832223 | 6 | 0 | 6 |
| KRT4 | SLURP1 | 0.827113 | 13 | 0 | 12 |
| KRT4 | SCEL | 0.826714 | 13 | 0 | 12 |
| KRT4 | VSIG10L | 0.824873 | 7 | 0 | 7 |
For details and further investigation, click here
