| Full name: LHFPL tetraspan subfamily member 4 | Alias Symbol: GARLH4 | ||
| Type: protein-coding gene | Cytoband: 3p25.3 | ||
| Entrez ID: 375323 | HGNC ID: HGNC:29568 | Ensembl Gene: ENSG00000156959 | OMIM ID: 610240 |
| Drug and gene relationship at DGIdb | |||
Expression of LHFPL4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LHFPL4 | 375323 | 228422_at | -0.0514 | 0.8266 | |
| GSE26886 | LHFPL4 | 375323 | 228422_at | -0.2792 | 0.0381 | |
| GSE45670 | LHFPL4 | 375323 | 228422_at | -0.0575 | 0.5475 | |
| GSE53622 | LHFPL4 | 375323 | 32899 | -0.3376 | 0.0035 | |
| GSE53624 | LHFPL4 | 375323 | 32899 | -1.3909 | 0.0000 | |
| GSE63941 | LHFPL4 | 375323 | 228422_at | 0.1711 | 0.7642 | |
| GSE77861 | LHFPL4 | 375323 | 228422_at | -0.1047 | 0.3392 | |
| GSE97050 | LHFPL4 | 375323 | A_32_P94 | -0.1273 | 0.7054 | |
| SRP133303 | LHFPL4 | 375323 | RNAseq | -1.3070 | 0.0062 | |
| TCGA | LHFPL4 | 375323 | RNAseq | -1.4620 | 0.0177 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by LHFPL4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LHFPL4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LHFPL4 | 375323 | 1 | 18 | 11 | |
| GSE20123 | LHFPL4 | 375323 | 1 | 18 | 11 | |
| GSE43470 | LHFPL4 | 375323 | 1 | 20 | 22 | |
| GSE46452 | LHFPL4 | 375323 | 2 | 17 | 40 | |
| GSE47630 | LHFPL4 | 375323 | 3 | 22 | 15 | |
| GSE54993 | LHFPL4 | 375323 | 6 | 1 | 63 | |
| GSE54994 | LHFPL4 | 375323 | 3 | 31 | 19 | |
| GSE60625 | LHFPL4 | 375323 | 5 | 0 | 6 | |
| GSE74703 | LHFPL4 | 375323 | 1 | 16 | 19 | |
| GSE74704 | LHFPL4 | 375323 | 1 | 11 | 8 | |
| TCGA | LHFPL4 | 375323 | 5 | 65 | 26 |
Total number of gains: 29; Total number of losses: 219; Total Number of normals: 240.
Somatic mutations of LHFPL4:
Generating mutation plots.
Highly correlated genes for LHFPL4:
Showing top 20/60 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LHFPL4 | FFAR2 | 0.723869 | 3 | 0 | 3 |
| LHFPL4 | GPR173 | 0.688443 | 3 | 0 | 3 |
| LHFPL4 | CRYBB3 | 0.684606 | 3 | 0 | 3 |
| LHFPL4 | UPB1 | 0.681209 | 3 | 0 | 3 |
| LHFPL4 | KRTAP6-1 | 0.674526 | 3 | 0 | 3 |
| LHFPL4 | DNAI1 | 0.659104 | 3 | 0 | 3 |
| LHFPL4 | APOA1 | 0.648989 | 3 | 0 | 3 |
| LHFPL4 | GRM6 | 0.64376 | 3 | 0 | 3 |
| LHFPL4 | CCDC33 | 0.639713 | 4 | 0 | 3 |
| LHFPL4 | CPNE6 | 0.631474 | 3 | 0 | 3 |
| LHFPL4 | ROBO3 | 0.631105 | 4 | 0 | 3 |
| LHFPL4 | ADAM21 | 0.629865 | 3 | 0 | 3 |
| LHFPL4 | ZBTB17 | 0.628022 | 3 | 0 | 3 |
| LHFPL4 | MFSD6L | 0.620741 | 6 | 0 | 5 |
| LHFPL4 | HES5 | 0.616517 | 3 | 0 | 3 |
| LHFPL4 | PAX2 | 0.615764 | 4 | 0 | 3 |
| LHFPL4 | PRDM16 | 0.609668 | 4 | 0 | 3 |
| LHFPL4 | IL37 | 0.60761 | 3 | 0 | 3 |
| LHFPL4 | FSCN3 | 0.601932 | 4 | 0 | 3 |
| LHFPL4 | SLC7A14 | 0.60056 | 4 | 0 | 3 |
For details and further investigation, click here
