| Full name: lin-7 homolog B, crumbs cell polarity complex component | Alias Symbol: MALS-2|LIN-7B|VELI2 | ||
| Type: protein-coding gene | Cytoband: 19q13.33 | ||
| Entrez ID: 64130 | HGNC ID: HGNC:17788 | Ensembl Gene: ENSG00000104863 | OMIM ID: 612331 |
| Drug and gene relationship at DGIdb | |||
Expression of LIN7B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LIN7B | 64130 | 219760_at | -0.0740 | 0.8454 | |
| GSE20347 | LIN7B | 64130 | 219760_at | -0.3775 | 0.0004 | |
| GSE23400 | LIN7B | 64130 | 219760_at | -0.2366 | 0.0001 | |
| GSE26886 | LIN7B | 64130 | 219760_at | -0.2688 | 0.0259 | |
| GSE29001 | LIN7B | 64130 | 219760_at | -0.2914 | 0.2390 | |
| GSE38129 | LIN7B | 64130 | 219760_at | -0.3690 | 0.0002 | |
| GSE45670 | LIN7B | 64130 | 219760_at | -0.1878 | 0.1454 | |
| GSE63941 | LIN7B | 64130 | 219760_at | -0.9437 | 0.0048 | |
| GSE77861 | LIN7B | 64130 | 219760_at | 0.0803 | 0.7136 | |
| GSE97050 | LIN7B | 64130 | A_23_P164912 | -0.1146 | 0.7438 | |
| SRP064894 | LIN7B | 64130 | RNAseq | 0.2013 | 0.5457 | |
| SRP133303 | LIN7B | 64130 | RNAseq | -0.2368 | 0.4290 | |
| SRP159526 | LIN7B | 64130 | RNAseq | 0.0548 | 0.8348 | |
| SRP193095 | LIN7B | 64130 | RNAseq | -0.4504 | 0.0018 | |
| SRP219564 | LIN7B | 64130 | RNAseq | -0.4591 | 0.1106 | |
| TCGA | LIN7B | 64130 | RNAseq | 0.1495 | 0.2690 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by LIN7B expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of LIN7B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LIN7B | 64130 | 4 | 4 | 22 | |
| GSE20123 | LIN7B | 64130 | 4 | 3 | 23 | |
| GSE43470 | LIN7B | 64130 | 4 | 10 | 29 | |
| GSE46452 | LIN7B | 64130 | 45 | 1 | 13 | |
| GSE47630 | LIN7B | 64130 | 9 | 6 | 25 | |
| GSE54993 | LIN7B | 64130 | 17 | 4 | 49 | |
| GSE54994 | LIN7B | 64130 | 4 | 14 | 35 | |
| GSE60625 | LIN7B | 64130 | 9 | 0 | 2 | |
| GSE74703 | LIN7B | 64130 | 4 | 7 | 25 | |
| GSE74704 | LIN7B | 64130 | 4 | 1 | 15 | |
| TCGA | LIN7B | 64130 | 14 | 18 | 64 |
Total number of gains: 118; Total number of losses: 68; Total Number of normals: 302.
Somatic mutations of LIN7B:
Generating mutation plots.
Highly correlated genes for LIN7B:
Showing top 20/427 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LIN7B | DVL1 | 0.752921 | 3 | 0 | 3 |
| LIN7B | CDC16 | 0.736202 | 3 | 0 | 3 |
| LIN7B | STK38 | 0.733855 | 3 | 0 | 3 |
| LIN7B | UBE4B | 0.721662 | 3 | 0 | 3 |
| LIN7B | ZNF844 | 0.712871 | 3 | 0 | 3 |
| LIN7B | CPEB2 | 0.700612 | 3 | 0 | 3 |
| LIN7B | PTAR1 | 0.69612 | 3 | 0 | 3 |
| LIN7B | C19orf18 | 0.694881 | 3 | 0 | 3 |
| LIN7B | LYSMD3 | 0.688855 | 3 | 0 | 3 |
| LIN7B | PNMA1 | 0.687005 | 3 | 0 | 3 |
| LIN7B | NUDCD3 | 0.68203 | 3 | 0 | 3 |
| LIN7B | DMAP1 | 0.677369 | 3 | 0 | 3 |
| LIN7B | ZNF583 | 0.676893 | 3 | 0 | 3 |
| LIN7B | ZNF324 | 0.670901 | 5 | 0 | 5 |
| LIN7B | TMEM159 | 0.670866 | 4 | 0 | 4 |
| LIN7B | EXOC1 | 0.667765 | 3 | 0 | 3 |
| LIN7B | BRK1 | 0.667627 | 3 | 0 | 3 |
| LIN7B | CDADC1 | 0.667441 | 3 | 0 | 3 |
| LIN7B | CHIC2 | 0.666 | 4 | 0 | 4 |
| LIN7B | NEK1 | 0.662725 | 4 | 0 | 3 |
For details and further investigation, click here
