| Full name: exocyst complex component 1 | Alias Symbol: SEC3|FLJ10893|BM-102|Sec3p | ||
| Type: protein-coding gene | Cytoband: 4q12 | ||
| Entrez ID: 55763 | HGNC ID: HGNC:30380 | Ensembl Gene: ENSG00000090989 | OMIM ID: 607879 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of EXOC1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EXOC1 | 55763 | 222127_s_at | -0.7339 | 0.1802 | |
| GSE20347 | EXOC1 | 55763 | 222127_s_at | -1.1153 | 0.0000 | |
| GSE23400 | EXOC1 | 55763 | 222127_s_at | -0.5979 | 0.0000 | |
| GSE26886 | EXOC1 | 55763 | 222127_s_at | -1.2084 | 0.0000 | |
| GSE29001 | EXOC1 | 55763 | 222127_s_at | -1.0252 | 0.0018 | |
| GSE38129 | EXOC1 | 55763 | 222127_s_at | -0.6579 | 0.0012 | |
| GSE45670 | EXOC1 | 55763 | 222127_s_at | -0.3440 | 0.2370 | |
| GSE53622 | EXOC1 | 55763 | 63314 | -0.3902 | 0.0000 | |
| GSE53624 | EXOC1 | 55763 | 63314 | -0.6853 | 0.0000 | |
| GSE63941 | EXOC1 | 55763 | 222127_s_at | -0.8127 | 0.1004 | |
| GSE77861 | EXOC1 | 55763 | 222127_s_at | -0.8579 | 0.0014 | |
| GSE97050 | EXOC1 | 55763 | A_23_P113972 | -0.0377 | 0.8882 | |
| SRP007169 | EXOC1 | 55763 | RNAseq | -1.4388 | 0.0008 | |
| SRP008496 | EXOC1 | 55763 | RNAseq | -1.1820 | 0.0000 | |
| SRP064894 | EXOC1 | 55763 | RNAseq | -0.6880 | 0.0006 | |
| SRP133303 | EXOC1 | 55763 | RNAseq | -0.5134 | 0.0038 | |
| SRP159526 | EXOC1 | 55763 | RNAseq | -1.4998 | 0.0000 | |
| SRP193095 | EXOC1 | 55763 | RNAseq | -0.9809 | 0.0000 | |
| SRP219564 | EXOC1 | 55763 | RNAseq | -1.1430 | 0.0075 | |
| TCGA | EXOC1 | 55763 | RNAseq | -0.0457 | 0.3642 |
Upregulated datasets: 0; Downregulated datasets: 7.
Survival by EXOC1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of EXOC1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EXOC1 | 55763 | 3 | 11 | 16 | |
| GSE20123 | EXOC1 | 55763 | 2 | 11 | 17 | |
| GSE43470 | EXOC1 | 55763 | 0 | 14 | 29 | |
| GSE46452 | EXOC1 | 55763 | 1 | 36 | 22 | |
| GSE47630 | EXOC1 | 55763 | 1 | 18 | 21 | |
| GSE54993 | EXOC1 | 55763 | 7 | 0 | 63 | |
| GSE54994 | EXOC1 | 55763 | 2 | 10 | 41 | |
| GSE60625 | EXOC1 | 55763 | 0 | 0 | 11 | |
| GSE74703 | EXOC1 | 55763 | 0 | 12 | 24 | |
| GSE74704 | EXOC1 | 55763 | 1 | 6 | 13 | |
| TCGA | EXOC1 | 55763 | 20 | 26 | 50 |
Total number of gains: 37; Total number of losses: 144; Total Number of normals: 307.
Somatic mutations of EXOC1:
Generating mutation plots.
Highly correlated genes for EXOC1:
Showing top 20/1628 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EXOC1 | SH3PXD2A-AS1 | 0.81271 | 3 | 0 | 3 |
| EXOC1 | SFTA2 | 0.786532 | 3 | 0 | 3 |
| EXOC1 | SMAGP | 0.784246 | 9 | 0 | 9 |
| EXOC1 | SREK1 | 0.779625 | 3 | 0 | 3 |
| EXOC1 | TEKT5 | 0.779123 | 3 | 0 | 3 |
| EXOC1 | CAPN14 | 0.772926 | 5 | 0 | 5 |
| EXOC1 | EPS8L1 | 0.772391 | 9 | 0 | 9 |
| EXOC1 | ULK3 | 0.770665 | 6 | 0 | 6 |
| EXOC1 | RBM47 | 0.76676 | 9 | 0 | 9 |
| EXOC1 | ALG14 | 0.76493 | 4 | 0 | 4 |
| EXOC1 | NAGK | 0.759941 | 10 | 0 | 10 |
| EXOC1 | RASSF5 | 0.756672 | 6 | 0 | 6 |
| EXOC1 | C15orf48 | 0.756447 | 5 | 0 | 5 |
| EXOC1 | TPRG1 | 0.753573 | 6 | 0 | 6 |
| EXOC1 | SCNN1B | 0.752647 | 9 | 0 | 9 |
| EXOC1 | RAB11A | 0.751963 | 10 | 0 | 10 |
| EXOC1 | ARPC1A | 0.750957 | 3 | 0 | 3 |
| EXOC1 | NOA1 | 0.750252 | 4 | 0 | 4 |
| EXOC1 | A2ML1 | 0.749558 | 5 | 0 | 5 |
| EXOC1 | LNX1 | 0.749545 | 7 | 0 | 7 |
For details and further investigation, click here
