| Full name: transketolase | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 3p21.1 | ||
| Entrez ID: 7086 | HGNC ID: HGNC:11834 | Ensembl Gene: ENSG00000163931 | OMIM ID: 606781 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of TKT:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TKT | 7086 | 208700_s_at | 0.3762 | 0.1529 | |
| GSE20347 | TKT | 7086 | 208700_s_at | -0.1921 | 0.5706 | |
| GSE23400 | TKT | 7086 | 208700_s_at | 0.2609 | 0.0507 | |
| GSE26886 | TKT | 7086 | 208700_s_at | 0.0762 | 0.7773 | |
| GSE29001 | TKT | 7086 | 208700_s_at | -0.4095 | 0.3473 | |
| GSE38129 | TKT | 7086 | 208700_s_at | 0.1272 | 0.6571 | |
| GSE45670 | TKT | 7086 | 208700_s_at | 0.2100 | 0.3765 | |
| GSE53622 | TKT | 7086 | 57426 | -0.3577 | 0.0025 | |
| GSE53624 | TKT | 7086 | 57426 | -0.0488 | 0.5990 | |
| GSE63941 | TKT | 7086 | 208700_s_at | 0.5119 | 0.2423 | |
| GSE77861 | TKT | 7086 | 208700_s_at | 0.1471 | 0.7497 | |
| GSE97050 | TKT | 7086 | A_23_P92082 | -0.0504 | 0.8095 | |
| SRP007169 | TKT | 7086 | RNAseq | 0.5603 | 0.1577 | |
| SRP008496 | TKT | 7086 | RNAseq | 0.2485 | 0.4222 | |
| SRP064894 | TKT | 7086 | RNAseq | -0.1752 | 0.4367 | |
| SRP133303 | TKT | 7086 | RNAseq | -0.2950 | 0.0839 | |
| SRP159526 | TKT | 7086 | RNAseq | 0.7851 | 0.2034 | |
| SRP193095 | TKT | 7086 | RNAseq | 0.0267 | 0.8813 | |
| SRP219564 | TKT | 7086 | RNAseq | -0.1484 | 0.7777 | |
| TCGA | TKT | 7086 | RNAseq | 0.2764 | 0.0001 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by TKT expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TKT:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TKT | 7086 | 0 | 19 | 11 | |
| GSE20123 | TKT | 7086 | 0 | 20 | 10 | |
| GSE43470 | TKT | 7086 | 0 | 18 | 25 | |
| GSE46452 | TKT | 7086 | 2 | 17 | 40 | |
| GSE47630 | TKT | 7086 | 1 | 24 | 15 | |
| GSE54993 | TKT | 7086 | 6 | 2 | 62 | |
| GSE54994 | TKT | 7086 | 0 | 32 | 21 | |
| GSE60625 | TKT | 7086 | 5 | 0 | 6 | |
| GSE74703 | TKT | 7086 | 0 | 14 | 22 | |
| GSE74704 | TKT | 7086 | 0 | 13 | 7 | |
| TCGA | TKT | 7086 | 0 | 78 | 18 |
Total number of gains: 14; Total number of losses: 237; Total Number of normals: 237.
Somatic mutations of TKT:
Generating mutation plots.
Highly correlated genes for TKT:
Showing top 20/319 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TKT | FJX1 | 0.783368 | 3 | 0 | 3 |
| TKT | SAMD1 | 0.773893 | 3 | 0 | 3 |
| TKT | LINGO1 | 0.754093 | 3 | 0 | 3 |
| TKT | NUFIP2 | 0.740887 | 3 | 0 | 3 |
| TKT | MARS2 | 0.738812 | 3 | 0 | 3 |
| TKT | KHNYN | 0.731403 | 3 | 0 | 3 |
| TKT | AKT1 | 0.726325 | 3 | 0 | 3 |
| TKT | GOSR1 | 0.722504 | 3 | 0 | 3 |
| TKT | RAB22A | 0.721994 | 3 | 0 | 3 |
| TKT | TMEM18 | 0.714083 | 4 | 0 | 4 |
| TKT | PGAP1 | 0.711708 | 3 | 0 | 3 |
| TKT | INO80B | 0.710017 | 3 | 0 | 3 |
| TKT | PLCB2 | 0.703922 | 3 | 0 | 3 |
| TKT | SNAPC2 | 0.701924 | 3 | 0 | 3 |
| TKT | COA6 | 0.688934 | 5 | 0 | 4 |
| TKT | TXNL4A | 0.687132 | 3 | 0 | 3 |
| TKT | KDM1B | 0.683313 | 3 | 0 | 3 |
| TKT | ARFGAP2 | 0.678897 | 3 | 0 | 3 |
| TKT | TAF10 | 0.677619 | 4 | 0 | 3 |
| TKT | IL6R | 0.674724 | 3 | 0 | 3 |
For details and further investigation, click here
