| Full name: lysophosphatidic acid receptor 4 | Alias Symbol: P2Y9|P2Y5-LIKE|P2RY9|LPA4 | ||
| Type: protein-coding gene | Cytoband: Xq21.1 | ||
| Entrez ID: 2846 | HGNC ID: HGNC:4478 | Ensembl Gene: ENSG00000147145 | OMIM ID: 300086 |
| Drug and gene relationship at DGIdb | |||
LPAR4 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04015 | Rap1 signaling pathway | |
| hsa04072 | Phospholipase D signaling pathway | |
| hsa04151 | PI3K-Akt signaling pathway |
Expression of LPAR4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LPAR4 | 2846 | 206960_at | -0.1500 | 0.5750 | |
| GSE20347 | LPAR4 | 2846 | 206960_at | -0.1031 | 0.2593 | |
| GSE23400 | LPAR4 | 2846 | 206960_at | -0.0614 | 0.0003 | |
| GSE26886 | LPAR4 | 2846 | 206960_at | -0.1988 | 0.1718 | |
| GSE29001 | LPAR4 | 2846 | 206960_at | -0.5295 | 0.0129 | |
| GSE38129 | LPAR4 | 2846 | 206960_at | -0.3311 | 0.0101 | |
| GSE45670 | LPAR4 | 2846 | 206960_at | -0.9437 | 0.0000 | |
| GSE53622 | LPAR4 | 2846 | 121324 | -0.7927 | 0.0001 | |
| GSE53624 | LPAR4 | 2846 | 121324 | -1.1470 | 0.0000 | |
| GSE63941 | LPAR4 | 2846 | 206960_at | -0.2716 | 0.1188 | |
| GSE77861 | LPAR4 | 2846 | 206960_at | -0.0039 | 0.9712 | |
| GSE97050 | LPAR4 | 2846 | A_23_P33868 | -0.2256 | 0.5144 | |
| SRP133303 | LPAR4 | 2846 | RNAseq | -0.1549 | 0.4566 | |
| SRP159526 | LPAR4 | 2846 | RNAseq | -1.6958 | 0.0017 | |
| SRP219564 | LPAR4 | 2846 | RNAseq | 0.2095 | 0.7097 | |
| TCGA | LPAR4 | 2846 | RNAseq | 0.0061 | 0.9882 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by LPAR4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LPAR4:
No record found for this gene.
Somatic mutations of LPAR4:
Generating mutation plots.
Highly correlated genes for LPAR4:
Showing top 20/419 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LPAR4 | NOSTRIN | 0.688694 | 4 | 0 | 4 |
| LPAR4 | NEGR1 | 0.686679 | 5 | 0 | 5 |
| LPAR4 | RBPMS2 | 0.685706 | 4 | 0 | 3 |
| LPAR4 | ARHGAP31 | 0.661131 | 5 | 0 | 4 |
| LPAR4 | MRGPRF | 0.659392 | 5 | 0 | 4 |
| LPAR4 | CYP2U1 | 0.655221 | 5 | 0 | 5 |
| LPAR4 | PCDH18 | 0.653225 | 4 | 0 | 4 |
| LPAR4 | LINC01354 | 0.65202 | 4 | 0 | 3 |
| LPAR4 | RERG | 0.651525 | 4 | 0 | 3 |
| LPAR4 | PABPC5 | 0.649264 | 5 | 0 | 4 |
| LPAR4 | C3orf70 | 0.647108 | 4 | 0 | 4 |
| LPAR4 | POLK | 0.64323 | 5 | 0 | 5 |
| LPAR4 | CCL14 | 0.642724 | 3 | 0 | 3 |
| LPAR4 | KLHL30 | 0.642472 | 3 | 0 | 3 |
| LPAR4 | SULT1C4 | 0.641543 | 3 | 0 | 3 |
| LPAR4 | GRIA2 | 0.636514 | 5 | 0 | 4 |
| LPAR4 | GALNT15 | 0.635818 | 4 | 0 | 4 |
| LPAR4 | KCNT2 | 0.635749 | 5 | 0 | 3 |
| LPAR4 | NEXN | 0.633109 | 5 | 0 | 4 |
| LPAR4 | RCSD1 | 0.632763 | 5 | 0 | 4 |
For details and further investigation, click here
