ROCK1

 

Full name: Rho associated coiled-coil containing protein kinase 1 Alias Symbol: p160ROCK
Type: protein-coding gene Cytoband: 18q11.1
Entrez ID: 6093 HGNC ID: HGNC:10251 Ensembl Gene: ENSG00000067900 OMIM ID: 601702
Drug and gene relationship at DGIdb
Screen Evidence:

 

ROCK1 involved pathways:

KEGG pathway Description View
hsa04022cGMP-PKG signaling pathway
hsa04024cAMP signaling pathway
hsa04062Chemokine signaling pathway
hsa04071Sphingolipid signaling pathway
hsa04270Vascular smooth muscle contraction
hsa04350TGF-beta signaling pathway
hsa04360Axon guidance
hsa04510Focal adhesion
hsa04611Platelet activation
hsa04670Leukocyte transendothelial migration
hsa04810Regulation of actin cytoskeleton
hsa04921Oxytocin signaling pathway
hsa05130Pathogenic Escherichia coli infection
hsa05132Salmonella infection
hsa05205Proteoglycans in cancer

 

Expression of ROCK1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ROCK1 6093 213044_at -0.6479 0.0854
GSE20347 ROCK1 6093 213044_at -0.0881 0.6073
GSE23400 ROCK1 6093 213044_at -0.0014 0.9905
GSE26886 ROCK1 6093 213044_at 0.3219 0.1324
GSE29001 ROCK1 6093 213044_at 0.1792 0.5941
GSE38129 ROCK1 6093 213044_at -0.3106 0.0292
GSE45670 ROCK1 6093 213044_at -0.5338 0.0001
GSE53622 ROCK1 6093 102141 -0.1784 0.0181
GSE53624 ROCK1 6093 79413 -0.0947 0.1475
GSE63941 ROCK1 6093 213044_at -0.6713 0.1623
GSE77861 ROCK1 6093 213044_at 0.3261 0.1226
GSE97050 ROCK1 6093 A_23_P130429 -0.3508 0.3293
SRP007169 ROCK1 6093 RNAseq 2.2402 0.0000
SRP008496 ROCK1 6093 RNAseq 1.9578 0.0000
SRP064894 ROCK1 6093 RNAseq -0.2337 0.3648
SRP133303 ROCK1 6093 RNAseq 0.2254 0.0891
SRP159526 ROCK1 6093 RNAseq -0.1909 0.4821
SRP193095 ROCK1 6093 RNAseq 0.2474 0.0084
SRP219564 ROCK1 6093 RNAseq -0.4910 0.3394
TCGA ROCK1 6093 RNAseq -0.1852 0.0002

Upregulated datasets: 2; Downregulated datasets: 0.  

 

Survival by ROCK1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of ROCK1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ROCK1 6093 3 6 21
GSE20123 ROCK1 6093 2 6 22
GSE43470 ROCK1 6093 2 1 40
GSE46452 ROCK1 6093 3 22 34
GSE47630 ROCK1 6093 7 17 16
GSE54993 ROCK1 6093 7 1 62
GSE54994 ROCK1 6093 3 11 39
GSE60625 ROCK1 6093 0 4 7
GSE74703 ROCK1 6093 1 1 34
GSE74704 ROCK1 6093 2 4 14
TCGA ROCK1 6093 21 15 60

Total number of gains: 51; Total number of losses: 88; Total Number of normals: 349.  

 

Somatic mutations of ROCK1:

 

Generating mutation plots.

 

Highly correlated genes for ROCK1:

 

Showing top 20/902 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ROCK1FILIP10.805262404
ROCK1TMEM167B0.769042303
ROCK1LRCH10.763317505
ROCK1SBF20.746618404
ROCK1EBAG90.743064303
ROCK1PTPN210.739265303
ROCK1AMOTL10.736932404
ROCK1CDS20.726407404
ROCK1OCRL0.724476404
ROCK1RASSF30.723793505
ROCK1TMOD10.723126504
ROCK1TMEM430.712775503
ROCK1KDM3B0.708921303
ROCK1MRVI10.70758504
ROCK1CYYR10.70447404
ROCK1DAPK10.701496505
ROCK1MYOCD0.700482504
ROCK1ZNF6550.697041404
ROCK1LRFN50.696674404
ROCK1KCNMB10.691117606

For details and further investigation, click here