| Full name: leucine rich repeat containing 37 member A3 | Alias Symbol: FLJ34306|KIAA0563 | ||
| Type: protein-coding gene | Cytoband: 17q24.1 | ||
| Entrez ID: 374819 | HGNC ID: HGNC:32427 | Ensembl Gene: ENSG00000176809 | OMIM ID: 616557 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of LRRC37A3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LRRC37A3 | 374819 | 244478_at | -0.1326 | 0.6075 | |
| GSE26886 | LRRC37A3 | 374819 | 244478_at | 0.1806 | 0.1155 | |
| GSE45670 | LRRC37A3 | 374819 | 244478_at | -0.1384 | 0.2437 | |
| GSE53622 | LRRC37A3 | 374819 | 73839 | -1.1853 | 0.0000 | |
| GSE53624 | LRRC37A3 | 374819 | 73839 | -1.0776 | 0.0000 | |
| GSE63941 | LRRC37A3 | 374819 | 244478_at | 0.2976 | 0.1232 | |
| GSE77861 | LRRC37A3 | 374819 | 244478_at | 0.0382 | 0.8275 | |
| GSE97050 | LRRC37A3 | 374819 | A_33_P3293432 | -0.6026 | 0.1194 | |
| SRP007169 | LRRC37A3 | 374819 | RNAseq | -0.2166 | 0.6653 | |
| SRP008496 | LRRC37A3 | 374819 | RNAseq | 0.7465 | 0.1799 | |
| SRP064894 | LRRC37A3 | 374819 | RNAseq | 0.2095 | 0.4608 | |
| SRP133303 | LRRC37A3 | 374819 | RNAseq | -0.1088 | 0.6737 | |
| SRP159526 | LRRC37A3 | 374819 | RNAseq | 0.2384 | 0.6088 | |
| SRP193095 | LRRC37A3 | 374819 | RNAseq | -0.0259 | 0.8850 | |
| SRP219564 | LRRC37A3 | 374819 | RNAseq | 0.1288 | 0.8099 | |
| TCGA | LRRC37A3 | 374819 | RNAseq | 0.0891 | 0.5584 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by LRRC37A3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LRRC37A3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LRRC37A3 | 374819 | 3 | 1 | 26 | |
| GSE20123 | LRRC37A3 | 374819 | 3 | 1 | 26 | |
| GSE43470 | LRRC37A3 | 374819 | 5 | 0 | 38 | |
| GSE46452 | LRRC37A3 | 374819 | 32 | 0 | 27 | |
| GSE47630 | LRRC37A3 | 374819 | 7 | 1 | 32 | |
| GSE54993 | LRRC37A3 | 374819 | 2 | 5 | 63 | |
| GSE54994 | LRRC37A3 | 374819 | 9 | 4 | 40 | |
| GSE60625 | LRRC37A3 | 374819 | 4 | 0 | 7 | |
| GSE74703 | LRRC37A3 | 374819 | 5 | 0 | 31 | |
| GSE74704 | LRRC37A3 | 374819 | 3 | 1 | 16 | |
| TCGA | LRRC37A3 | 374819 | 30 | 8 | 58 |
Total number of gains: 103; Total number of losses: 21; Total Number of normals: 364.
Somatic mutations of LRRC37A3:
Generating mutation plots.
Highly correlated genes for LRRC37A3:
Showing top 20/186 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LRRC37A3 | IQCF1 | 0.715171 | 3 | 0 | 3 |
| LRRC37A3 | MORN3 | 0.688946 | 3 | 0 | 3 |
| LRRC37A3 | TEAD3 | 0.680604 | 3 | 0 | 3 |
| LRRC37A3 | UPK3B | 0.679191 | 3 | 0 | 3 |
| LRRC37A3 | C19orf57 | 0.675569 | 3 | 0 | 3 |
| LRRC37A3 | LRRC37A2 | 0.67074 | 7 | 0 | 5 |
| LRRC37A3 | PHF12 | 0.666064 | 3 | 0 | 3 |
| LRRC37A3 | ACOT8 | 0.656153 | 3 | 0 | 3 |
| LRRC37A3 | NCCRP1 | 0.655037 | 3 | 0 | 3 |
| LRRC37A3 | MUC5AC | 0.654405 | 3 | 0 | 3 |
| LRRC37A3 | TCP11L2 | 0.65268 | 5 | 0 | 5 |
| LRRC37A3 | ST6GALNAC1 | 0.652384 | 4 | 0 | 4 |
| LRRC37A3 | ZNRF1 | 0.641937 | 3 | 0 | 3 |
| LRRC37A3 | GYS2 | 0.639424 | 4 | 0 | 4 |
| LRRC37A3 | CRISP2 | 0.638732 | 5 | 0 | 4 |
| LRRC37A3 | TMPRSS11A | 0.638153 | 3 | 0 | 3 |
| LRRC37A3 | RHOF | 0.636821 | 3 | 0 | 3 |
| LRRC37A3 | MAST4 | 0.634537 | 3 | 0 | 3 |
| LRRC37A3 | SYNRG | 0.63 | 4 | 0 | 4 |
| LRRC37A3 | IKZF2 | 0.627717 | 5 | 0 | 4 |
For details and further investigation, click here
