POLA2

 

Full name: DNA polymerase alpha 2, accessory subunit Alias Symbol: FLJ21662
Type: protein-coding gene Cytoband: 11q13.1
Entrez ID: 23649 HGNC ID: HGNC:30073 Ensembl Gene: ENSG00000014138 OMIM ID: 
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of POLA2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 POLA2 23649 204441_s_at 0.6019 0.1185
GSE20347 POLA2 23649 204441_s_at 0.9656 0.0000
GSE23400 POLA2 23649 204441_s_at 0.5715 0.0000
GSE26886 POLA2 23649 204441_s_at 0.2089 0.4092
GSE29001 POLA2 23649 204441_s_at 0.7852 0.0003
GSE38129 POLA2 23649 204441_s_at 0.9046 0.0000
GSE45670 POLA2 23649 204441_s_at 0.5899 0.0009
GSE53622 POLA2 23649 148462 1.2643 0.0000
GSE53624 POLA2 23649 148462 1.5273 0.0000
GSE63941 POLA2 23649 204441_s_at 1.9726 0.0015
GSE77861 POLA2 23649 204441_s_at 0.2632 0.1679
GSE97050 POLA2 23649 A_23_P161615 0.7966 0.1727
SRP007169 POLA2 23649 RNAseq 1.2851 0.0006
SRP008496 POLA2 23649 RNAseq 1.2510 0.0000
SRP064894 POLA2 23649 RNAseq 0.8219 0.0000
SRP133303 POLA2 23649 RNAseq 0.9689 0.0000
SRP159526 POLA2 23649 RNAseq 1.2331 0.0002
SRP193095 POLA2 23649 RNAseq 0.8314 0.0000
SRP219564 POLA2 23649 RNAseq 0.4460 0.3569
TCGA POLA2 23649 RNAseq 0.4386 0.0000

Upregulated datasets: 6; Downregulated datasets: 0.  

 

Survival by POLA2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of POLA2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 POLA2 23649 7 6 17
GSE20123 POLA2 23649 7 6 17
GSE43470 POLA2 23649 4 1 38
GSE46452 POLA2 23649 11 3 45
GSE47630 POLA2 23649 7 5 28
GSE54993 POLA2 23649 3 0 67
GSE54994 POLA2 23649 6 5 42
GSE60625 POLA2 23649 0 3 8
GSE74703 POLA2 23649 3 0 33
GSE74704 POLA2 23649 5 4 11
TCGA POLA2 23649 23 7 66

Total number of gains: 76; Total number of losses: 40; Total Number of normals: 372.  

 

Somatic mutations of POLA2:

 

Generating mutation plots.

 

Highly correlated genes for POLA2:

 

Showing top 20/1870 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
POLA2PYCR20.787651303
POLA2KNSTRN0.784023606
POLA2SLC35B20.775926303
POLA2MMS22L0.770206303
POLA2DKC10.757712303
POLA2ZNF7070.757051303
POLA2SKA30.752116707
POLA2LRTOMT0.751114303
POLA2MCM20.74866711011
POLA2ZDHHC160.745334606
POLA2UBE2C0.74326612011
POLA2USP420.743185606
POLA2CDCA30.7414912011
POLA2SPC240.741381707
POLA2DNMT10.74102611011
POLA2SCNM10.740711303
POLA2CCNB20.74055111011
POLA2FEN10.737257909
POLA2MCM60.73713112012
POLA2NCAPG20.73381111011

For details and further investigation, click here