| Full name: semaphorin 4A | Alias Symbol: SemB|FLJ12287|CORD10 | ||
| Type: protein-coding gene | Cytoband: 1q22 | ||
| Entrez ID: 64218 | HGNC ID: HGNC:10729 | Ensembl Gene: ENSG00000196189 | OMIM ID: 607292 |
| Drug and gene relationship at DGIdb | |||
SEMA4A involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04360 | Axon guidance |
Expression of SEMA4A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SEMA4A | 64218 | 219259_at | -0.0622 | 0.9124 | |
| GSE20347 | SEMA4A | 64218 | 219259_at | -0.5255 | 0.0000 | |
| GSE23400 | SEMA4A | 64218 | 219259_at | -0.2525 | 0.0000 | |
| GSE26886 | SEMA4A | 64218 | 219259_at | -0.7163 | 0.0021 | |
| GSE29001 | SEMA4A | 64218 | 219259_at | -0.5603 | 0.0035 | |
| GSE38129 | SEMA4A | 64218 | 219259_at | -0.2505 | 0.1175 | |
| GSE45670 | SEMA4A | 64218 | 219259_at | -0.2606 | 0.1072 | |
| GSE53622 | SEMA4A | 64218 | 63194 | -0.2150 | 0.0787 | |
| GSE53624 | SEMA4A | 64218 | 63194 | -0.4589 | 0.0000 | |
| GSE63941 | SEMA4A | 64218 | 219259_at | 1.1416 | 0.0139 | |
| GSE77861 | SEMA4A | 64218 | 219259_at | -0.3234 | 0.1497 | |
| GSE97050 | SEMA4A | 64218 | A_23_P23438 | 0.0331 | 0.8923 | |
| SRP007169 | SEMA4A | 64218 | RNAseq | -1.7010 | 0.0000 | |
| SRP008496 | SEMA4A | 64218 | RNAseq | -1.4000 | 0.0000 | |
| SRP064894 | SEMA4A | 64218 | RNAseq | -0.4722 | 0.0230 | |
| SRP133303 | SEMA4A | 64218 | RNAseq | -0.7517 | 0.0090 | |
| SRP159526 | SEMA4A | 64218 | RNAseq | -0.0226 | 0.9480 | |
| SRP193095 | SEMA4A | 64218 | RNAseq | -0.4752 | 0.0148 | |
| SRP219564 | SEMA4A | 64218 | RNAseq | -0.2159 | 0.7357 | |
| TCGA | SEMA4A | 64218 | RNAseq | 0.2745 | 0.0006 |
Upregulated datasets: 1; Downregulated datasets: 2.
Survival by SEMA4A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SEMA4A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SEMA4A | 64218 | 14 | 0 | 16 | |
| GSE20123 | SEMA4A | 64218 | 13 | 0 | 17 | |
| GSE43470 | SEMA4A | 64218 | 7 | 2 | 34 | |
| GSE46452 | SEMA4A | 64218 | 2 | 1 | 56 | |
| GSE47630 | SEMA4A | 64218 | 14 | 0 | 26 | |
| GSE54993 | SEMA4A | 64218 | 0 | 5 | 65 | |
| GSE54994 | SEMA4A | 64218 | 16 | 0 | 37 | |
| GSE60625 | SEMA4A | 64218 | 0 | 0 | 11 | |
| GSE74703 | SEMA4A | 64218 | 7 | 2 | 27 | |
| GSE74704 | SEMA4A | 64218 | 6 | 0 | 14 | |
| TCGA | SEMA4A | 64218 | 38 | 2 | 56 |
Total number of gains: 117; Total number of losses: 12; Total Number of normals: 359.
Somatic mutations of SEMA4A:
Generating mutation plots.
Highly correlated genes for SEMA4A:
Showing top 20/1071 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SEMA4A | TMEM219 | 0.807304 | 3 | 0 | 3 |
| SEMA4A | FAM166A | 0.775977 | 3 | 0 | 3 |
| SEMA4A | RAB4B | 0.765877 | 4 | 0 | 4 |
| SEMA4A | USP21 | 0.764301 | 3 | 0 | 3 |
| SEMA4A | NLGN3 | 0.764209 | 4 | 0 | 4 |
| SEMA4A | SH3BP2 | 0.732696 | 3 | 0 | 3 |
| SEMA4A | PCNT | 0.730918 | 3 | 0 | 3 |
| SEMA4A | LRTOMT | 0.729473 | 3 | 0 | 3 |
| SEMA4A | CHCHD5 | 0.715328 | 3 | 0 | 3 |
| SEMA4A | RAD23B | 0.714698 | 3 | 0 | 3 |
| SEMA4A | SYNGR2 | 0.713955 | 3 | 0 | 3 |
| SEMA4A | JOSD2 | 0.711139 | 3 | 0 | 3 |
| SEMA4A | ZNF416 | 0.709416 | 3 | 0 | 3 |
| SEMA4A | ABHD14B | 0.709143 | 5 | 0 | 4 |
| SEMA4A | COX19 | 0.709082 | 3 | 0 | 3 |
| SEMA4A | SLC35A4 | 0.700839 | 5 | 0 | 4 |
| SEMA4A | TRAPPC1 | 0.70069 | 4 | 0 | 4 |
| SEMA4A | TXNDC11 | 0.698454 | 3 | 0 | 3 |
| SEMA4A | XRRA1 | 0.697749 | 3 | 0 | 3 |
| SEMA4A | RECQL5 | 0.695923 | 10 | 0 | 9 |
For details and further investigation, click here
