| Full name: ribosomal protein S6 kinase A4 | Alias Symbol: RSK-B|MSK2 | ||
| Type: protein-coding gene | Cytoband: 11q13.1 | ||
| Entrez ID: 8986 | HGNC ID: HGNC:10433 | Ensembl Gene: ENSG00000162302 | OMIM ID: 603606 |
| Drug and gene relationship at DGIdb | |||
RPS6KA4 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04010 | MAPK signaling pathway | |
| hsa04668 | TNF signaling pathway |
Expression of RPS6KA4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RPS6KA4 | 8986 | 204632_at | 0.4180 | 0.1438 | |
| GSE20347 | RPS6KA4 | 8986 | 204632_at | -0.0191 | 0.8521 | |
| GSE23400 | RPS6KA4 | 8986 | 204632_at | 0.1321 | 0.0021 | |
| GSE26886 | RPS6KA4 | 8986 | 204632_at | 0.0964 | 0.5463 | |
| GSE29001 | RPS6KA4 | 8986 | 204632_at | -0.0349 | 0.8530 | |
| GSE38129 | RPS6KA4 | 8986 | 204632_at | 0.0524 | 0.5739 | |
| GSE45670 | RPS6KA4 | 8986 | 204632_at | 0.2900 | 0.0330 | |
| GSE53622 | RPS6KA4 | 8986 | 50899 | 0.2949 | 0.0424 | |
| GSE53624 | RPS6KA4 | 8986 | 50899 | 0.6501 | 0.0000 | |
| GSE63941 | RPS6KA4 | 8986 | 204632_at | 0.6706 | 0.0179 | |
| GSE77861 | RPS6KA4 | 8986 | 204632_at | 0.0181 | 0.9314 | |
| GSE97050 | RPS6KA4 | 8986 | A_23_P35791 | 0.6406 | 0.1949 | |
| SRP007169 | RPS6KA4 | 8986 | RNAseq | -0.4493 | 0.2622 | |
| SRP008496 | RPS6KA4 | 8986 | RNAseq | -0.2643 | 0.3341 | |
| SRP064894 | RPS6KA4 | 8986 | RNAseq | 0.7168 | 0.0001 | |
| SRP133303 | RPS6KA4 | 8986 | RNAseq | 0.5127 | 0.0266 | |
| SRP159526 | RPS6KA4 | 8986 | RNAseq | -0.1192 | 0.6311 | |
| SRP193095 | RPS6KA4 | 8986 | RNAseq | 0.4092 | 0.0056 | |
| SRP219564 | RPS6KA4 | 8986 | RNAseq | 0.3521 | 0.4181 | |
| TCGA | RPS6KA4 | 8986 | RNAseq | 0.2118 | 0.0009 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by RPS6KA4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RPS6KA4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RPS6KA4 | 8986 | 6 | 5 | 19 | |
| GSE20123 | RPS6KA4 | 8986 | 6 | 5 | 19 | |
| GSE43470 | RPS6KA4 | 8986 | 1 | 3 | 39 | |
| GSE46452 | RPS6KA4 | 8986 | 8 | 4 | 47 | |
| GSE47630 | RPS6KA4 | 8986 | 4 | 6 | 30 | |
| GSE54993 | RPS6KA4 | 8986 | 3 | 0 | 67 | |
| GSE54994 | RPS6KA4 | 8986 | 6 | 5 | 42 | |
| GSE60625 | RPS6KA4 | 8986 | 0 | 3 | 8 | |
| GSE74703 | RPS6KA4 | 8986 | 1 | 1 | 34 | |
| GSE74704 | RPS6KA4 | 8986 | 4 | 3 | 13 | |
| TCGA | RPS6KA4 | 8986 | 21 | 9 | 66 |
Total number of gains: 60; Total number of losses: 44; Total Number of normals: 384.
Somatic mutations of RPS6KA4:
Generating mutation plots.
Highly correlated genes for RPS6KA4:
Showing top 20/585 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RPS6KA4 | FOXRED2 | 0.798001 | 3 | 0 | 3 |
| RPS6KA4 | SERPINA1 | 0.762836 | 3 | 0 | 3 |
| RPS6KA4 | NCAPD2 | 0.739054 | 3 | 0 | 3 |
| RPS6KA4 | PRELID1 | 0.727865 | 3 | 0 | 3 |
| RPS6KA4 | MRPL36 | 0.726706 | 3 | 0 | 3 |
| RPS6KA4 | TNFAIP1 | 0.725559 | 3 | 0 | 3 |
| RPS6KA4 | ARHGEF11 | 0.717163 | 4 | 0 | 3 |
| RPS6KA4 | RAVER1 | 0.714397 | 3 | 0 | 3 |
| RPS6KA4 | JAK3 | 0.703547 | 3 | 0 | 3 |
| RPS6KA4 | ILF3 | 0.702311 | 3 | 0 | 3 |
| RPS6KA4 | CDC42BPG | 0.69914 | 3 | 0 | 3 |
| RPS6KA4 | NPFF | 0.698826 | 3 | 0 | 3 |
| RPS6KA4 | RFC3 | 0.697768 | 4 | 0 | 3 |
| RPS6KA4 | FKBP4 | 0.69696 | 3 | 0 | 3 |
| RPS6KA4 | CXCR5 | 0.690307 | 3 | 0 | 3 |
| RPS6KA4 | MCMBP | 0.685564 | 4 | 0 | 3 |
| RPS6KA4 | CD22 | 0.675363 | 4 | 0 | 4 |
| RPS6KA4 | LTA | 0.674958 | 4 | 0 | 4 |
| RPS6KA4 | INO80B | 0.673268 | 6 | 0 | 5 |
| RPS6KA4 | NADSYN1 | 0.672989 | 4 | 0 | 3 |
For details and further investigation, click here
