| Full name: lysophospholipase 1 | Alias Symbol: LPL1|APT-1 | ||
| Type: protein-coding gene | Cytoband: 8q11.23 | ||
| Entrez ID: 10434 | HGNC ID: HGNC:6737 | Ensembl Gene: ENSG00000120992 | OMIM ID: 605599 |
Screen Evidence:
| |||
Expression of LYPLA1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LYPLA1 | 10434 | 212449_s_at | 0.0505 | 0.9510 | |
| GSE20347 | LYPLA1 | 10434 | 212449_s_at | -0.1381 | 0.3684 | |
| GSE23400 | LYPLA1 | 10434 | 212449_s_at | -0.0527 | 0.6764 | |
| GSE26886 | LYPLA1 | 10434 | 212449_s_at | -0.4668 | 0.0315 | |
| GSE29001 | LYPLA1 | 10434 | 203007_x_at | -0.1825 | 0.6828 | |
| GSE38129 | LYPLA1 | 10434 | 212449_s_at | 0.0333 | 0.8730 | |
| GSE45670 | LYPLA1 | 10434 | 212449_s_at | 0.0930 | 0.4783 | |
| GSE53622 | LYPLA1 | 10434 | 62294 | 0.0098 | 0.9202 | |
| GSE53624 | LYPLA1 | 10434 | 31433 | -0.4733 | 0.0000 | |
| GSE63941 | LYPLA1 | 10434 | 212449_s_at | 0.7019 | 0.0238 | |
| GSE77861 | LYPLA1 | 10434 | 212449_s_at | -0.3478 | 0.1216 | |
| GSE97050 | LYPLA1 | 10434 | A_23_P214091 | 0.8120 | 0.2055 | |
| SRP007169 | LYPLA1 | 10434 | RNAseq | -1.1812 | 0.0059 | |
| SRP008496 | LYPLA1 | 10434 | RNAseq | -1.1498 | 0.0000 | |
| SRP064894 | LYPLA1 | 10434 | RNAseq | -0.2270 | 0.4333 | |
| SRP133303 | LYPLA1 | 10434 | RNAseq | -0.0055 | 0.9779 | |
| SRP159526 | LYPLA1 | 10434 | RNAseq | -0.7128 | 0.0969 | |
| SRP193095 | LYPLA1 | 10434 | RNAseq | -0.6887 | 0.0001 | |
| SRP219564 | LYPLA1 | 10434 | RNAseq | -0.8348 | 0.0805 | |
| TCGA | LYPLA1 | 10434 | RNAseq | 0.0984 | 0.0494 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by LYPLA1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LYPLA1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LYPLA1 | 10434 | 14 | 2 | 14 | |
| GSE20123 | LYPLA1 | 10434 | 14 | 2 | 14 | |
| GSE43470 | LYPLA1 | 10434 | 13 | 3 | 27 | |
| GSE46452 | LYPLA1 | 10434 | 20 | 3 | 36 | |
| GSE47630 | LYPLA1 | 10434 | 23 | 1 | 16 | |
| GSE54993 | LYPLA1 | 10434 | 1 | 16 | 53 | |
| GSE54994 | LYPLA1 | 10434 | 28 | 0 | 25 | |
| GSE60625 | LYPLA1 | 10434 | 0 | 4 | 7 | |
| GSE74703 | LYPLA1 | 10434 | 12 | 2 | 22 | |
| GSE74704 | LYPLA1 | 10434 | 10 | 0 | 10 | |
| TCGA | LYPLA1 | 10434 | 43 | 9 | 44 |
Total number of gains: 178; Total number of losses: 42; Total Number of normals: 268.
Somatic mutations of LYPLA1:
Generating mutation plots.
Highly correlated genes for LYPLA1:
Showing top 20/466 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LYPLA1 | FAM110A | 0.727451 | 3 | 0 | 3 |
| LYPLA1 | SLC10A7 | 0.721968 | 4 | 0 | 3 |
| LYPLA1 | DNAJC7 | 0.717049 | 3 | 0 | 3 |
| LYPLA1 | FRMD8 | 0.682419 | 3 | 0 | 3 |
| LYPLA1 | ACTR3C | 0.672235 | 4 | 0 | 4 |
| LYPLA1 | PTBP3 | 0.664592 | 8 | 0 | 7 |
| LYPLA1 | IL1RL2 | 0.660857 | 6 | 0 | 4 |
| LYPLA1 | PHF23 | 0.660129 | 4 | 0 | 4 |
| LYPLA1 | RCC1 | 0.656305 | 3 | 0 | 3 |
| LYPLA1 | ZNF92 | 0.650391 | 3 | 0 | 3 |
| LYPLA1 | APRT | 0.646746 | 4 | 0 | 4 |
| LYPLA1 | RMDN1 | 0.645535 | 7 | 0 | 6 |
| LYPLA1 | ADCY7 | 0.645096 | 4 | 0 | 3 |
| LYPLA1 | TBC1D30 | 0.644855 | 3 | 0 | 3 |
| LYPLA1 | BUB3 | 0.641821 | 3 | 0 | 3 |
| LYPLA1 | XRCC4 | 0.640134 | 3 | 0 | 3 |
| LYPLA1 | TMEM161B | 0.634806 | 4 | 0 | 4 |
| LYPLA1 | ZNF823 | 0.629836 | 4 | 0 | 3 |
| LYPLA1 | RPF1 | 0.629245 | 3 | 0 | 3 |
| LYPLA1 | B4GALT5 | 0.627044 | 4 | 0 | 3 |
For details and further investigation, click here
