| Full name: X-ray repair cross complementing 4 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 5q14.2 | ||
| Entrez ID: 7518 | HGNC ID: HGNC:12831 | Ensembl Gene: ENSG00000152422 | OMIM ID: 194363 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of XRCC4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | XRCC4 | 7518 | 205071_x_at | 0.2853 | 0.5955 | |
| GSE20347 | XRCC4 | 7518 | 205071_x_at | 0.4257 | 0.0213 | |
| GSE23400 | XRCC4 | 7518 | 210812_at | -0.0080 | 0.7068 | |
| GSE26886 | XRCC4 | 7518 | 205071_x_at | -0.1010 | 0.7175 | |
| GSE29001 | XRCC4 | 7518 | 205071_x_at | 0.2776 | 0.1981 | |
| GSE38129 | XRCC4 | 7518 | 205071_x_at | 0.6866 | 0.0001 | |
| GSE45670 | XRCC4 | 7518 | 205071_x_at | 0.6913 | 0.0001 | |
| GSE53622 | XRCC4 | 7518 | 111142 | 0.6859 | 0.0000 | |
| GSE53624 | XRCC4 | 7518 | 111142 | 0.6045 | 0.0000 | |
| GSE63941 | XRCC4 | 7518 | 205071_x_at | 0.7347 | 0.0876 | |
| GSE77861 | XRCC4 | 7518 | 205071_x_at | 0.1131 | 0.6673 | |
| GSE97050 | XRCC4 | 7518 | A_23_P122174 | 0.6243 | 0.2463 | |
| SRP007169 | XRCC4 | 7518 | RNAseq | 0.7728 | 0.1585 | |
| SRP008496 | XRCC4 | 7518 | RNAseq | 0.5122 | 0.1752 | |
| SRP064894 | XRCC4 | 7518 | RNAseq | 0.5546 | 0.0013 | |
| SRP133303 | XRCC4 | 7518 | RNAseq | 0.8418 | 0.0001 | |
| SRP159526 | XRCC4 | 7518 | RNAseq | 0.0700 | 0.8437 | |
| SRP193095 | XRCC4 | 7518 | RNAseq | -0.1791 | 0.3027 | |
| SRP219564 | XRCC4 | 7518 | RNAseq | 0.1563 | 0.7631 | |
| TCGA | XRCC4 | 7518 | RNAseq | 0.3528 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by XRCC4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of XRCC4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | XRCC4 | 7518 | 1 | 14 | 15 | |
| GSE20123 | XRCC4 | 7518 | 1 | 14 | 15 | |
| GSE43470 | XRCC4 | 7518 | 2 | 10 | 31 | |
| GSE46452 | XRCC4 | 7518 | 0 | 28 | 31 | |
| GSE47630 | XRCC4 | 7518 | 1 | 19 | 20 | |
| GSE54993 | XRCC4 | 7518 | 8 | 1 | 61 | |
| GSE54994 | XRCC4 | 7518 | 1 | 18 | 34 | |
| GSE60625 | XRCC4 | 7518 | 0 | 0 | 11 | |
| GSE74703 | XRCC4 | 7518 | 1 | 7 | 28 | |
| GSE74704 | XRCC4 | 7518 | 1 | 7 | 12 | |
| TCGA | XRCC4 | 7518 | 4 | 47 | 45 |
Total number of gains: 20; Total number of losses: 165; Total Number of normals: 303.
Somatic mutations of XRCC4:
Generating mutation plots.
Highly correlated genes for XRCC4:
Showing top 20/1194 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| XRCC4 | PDE7A | 0.744489 | 3 | 0 | 3 |
| XRCC4 | RHBDF2 | 0.738751 | 3 | 0 | 3 |
| XRCC4 | MVP | 0.73209 | 3 | 0 | 3 |
| XRCC4 | GEN1 | 0.725565 | 3 | 0 | 3 |
| XRCC4 | ELOF1 | 0.721587 | 3 | 0 | 3 |
| XRCC4 | FLNB | 0.719096 | 3 | 0 | 3 |
| XRCC4 | MTHFD1L | 0.718125 | 3 | 0 | 3 |
| XRCC4 | RSL24D1 | 0.704029 | 5 | 0 | 4 |
| XRCC4 | SEC22C | 0.700114 | 3 | 0 | 3 |
| XRCC4 | TNFRSF21 | 0.697951 | 4 | 0 | 3 |
| XRCC4 | ZDHHC16 | 0.692847 | 4 | 0 | 3 |
| XRCC4 | PSMA2 | 0.692335 | 7 | 0 | 6 |
| XRCC4 | ANKRD50 | 0.687275 | 3 | 0 | 3 |
| XRCC4 | ZNF90 | 0.685901 | 3 | 0 | 3 |
| XRCC4 | MRPS12 | 0.684034 | 4 | 0 | 4 |
| XRCC4 | FAM89A | 0.682742 | 3 | 0 | 3 |
| XRCC4 | NOP58 | 0.681755 | 3 | 0 | 3 |
| XRCC4 | FITM2 | 0.680334 | 3 | 0 | 3 |
| XRCC4 | ZNF319 | 0.679021 | 4 | 0 | 3 |
| XRCC4 | NRM | 0.678124 | 4 | 0 | 4 |
For details and further investigation, click here
