BUB3

 

Full name: BUB3 mitotic checkpoint protein Alias Symbol: BUB3L
Type: protein-coding gene Cytoband: 10q26.13
Entrez ID: 9184 HGNC ID: HGNC:1151 Ensembl Gene: ENSG00000154473 OMIM ID: 603719
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

BUB3 involved pathways:

KEGG pathway Description View
hsa04110Cell cycle
hsa05166HTLV-I infection

 

Expression of BUB3:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 BUB3 9184 209974_s_at 0.2955 0.4038
GSE20347 BUB3 9184 209974_s_at 0.4579 0.0004
GSE23400 BUB3 9184 209974_s_at 0.7224 0.0000
GSE26886 BUB3 9184 209974_s_at 0.2156 0.1311
GSE29001 BUB3 9184 209974_s_at 0.6664 0.0016
GSE38129 BUB3 9184 209974_s_at 0.5370 0.0000
GSE45670 BUB3 9184 209974_s_at 0.2015 0.1066
GSE53622 BUB3 9184 90867 0.6116 0.0000
GSE53624 BUB3 9184 90867 0.7920 0.0000
GSE63941 BUB3 9184 201457_x_at 1.7972 0.0000
GSE77861 BUB3 9184 209974_s_at 0.1040 0.7516
GSE97050 BUB3 9184 A_23_P46924 0.6344 0.2292
SRP007169 BUB3 9184 RNAseq 0.0932 0.8352
SRP008496 BUB3 9184 RNAseq -0.0578 0.8150
SRP064894 BUB3 9184 RNAseq 0.2216 0.1535
SRP133303 BUB3 9184 RNAseq 0.3443 0.0266
SRP159526 BUB3 9184 RNAseq 0.0347 0.8932
SRP193095 BUB3 9184 RNAseq 0.1822 0.0972
SRP219564 BUB3 9184 RNAseq 0.2664 0.4518
TCGA BUB3 9184 RNAseq 0.1991 0.0000

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by BUB3 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of BUB3:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 BUB3 9184 1 6 23
GSE20123 BUB3 9184 1 6 23
GSE43470 BUB3 9184 0 9 34
GSE46452 BUB3 9184 0 11 48
GSE47630 BUB3 9184 2 14 24
GSE54993 BUB3 9184 8 1 61
GSE54994 BUB3 9184 1 9 43
GSE60625 BUB3 9184 0 0 11
GSE74703 BUB3 9184 0 6 30
GSE74704 BUB3 9184 1 2 17
TCGA BUB3 9184 4 27 65

Total number of gains: 18; Total number of losses: 91; Total Number of normals: 379.  

 

Somatic mutations of BUB3:

 

Generating mutation plots.

 

Highly correlated genes for BUB3:

 

Showing top 20/1476 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
BUB3AP1S30.785745303
BUB3KIF110.74327112012
BUB3KIAA15220.74315303
BUB3CHCHD50.730754303
BUB3TADA10.729172303
BUB3NFYB0.723074303
BUB3NOLC10.72128311011
BUB3GINS10.70986711011
BUB3BTF3L40.709596303
BUB3ARHGAP180.706363303
BUB3MKI670.70369212011
BUB3SLC19A10.702985303
BUB3SNAP470.700733303
BUB3CCNA20.70055312011
BUB3IRX30.700227303
BUB3INTS100.697964303
BUB3SMYD50.696249707
BUB3SASS60.69421808
BUB3CDK10.69377512011
BUB3ACTL6A0.69289611011

For details and further investigation, click here