TRAF3

 

Full name: TNF receptor associated factor 3 Alias Symbol: CAP-1|CD40bp|CRAF1|LAP1|RNF118
Type: protein-coding gene Cytoband: 14q32.32
Entrez ID: 7187 HGNC ID: HGNC:12033 Ensembl Gene: ENSG00000131323 OMIM ID: 601896
Drug and gene relationship at DGIdb
Screen Evidence:
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

TRAF3 involved pathways:

KEGG pathway Description View
hsa04064NF-kappa B signaling pathway
hsa04620Toll-like receptor signaling pathway
hsa04622RIG-I-like receptor signaling pathway
hsa05160Hepatitis C
hsa05168Herpes simplex infection
hsa05169Epstein-Barr virus infection
hsa05200Pathways in cancer
hsa05222Small cell lung cancer

 

Expression of TRAF3:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 TRAF3 7187 221571_at 0.9255 0.0250
GSE20347 TRAF3 7187 221571_at 0.4835 0.0014
GSE23400 TRAF3 7187 221571_at 0.5165 0.0000
GSE26886 TRAF3 7187 221571_at 0.3986 0.1676
GSE29001 TRAF3 7187 221571_at 0.9196 0.0002
GSE38129 TRAF3 7187 221571_at 0.5394 0.0003
GSE45670 TRAF3 7187 221571_at 0.7625 0.0004
GSE53622 TRAF3 7187 40044 0.7476 0.0000
GSE53624 TRAF3 7187 40044 0.8811 0.0000
GSE63941 TRAF3 7187 221571_at -0.2702 0.5947
GSE77861 TRAF3 7187 221571_at 0.6699 0.0431
GSE97050 TRAF3 7187 A_23_P37068 0.8300 0.1194
SRP007169 TRAF3 7187 RNAseq 1.6721 0.0000
SRP008496 TRAF3 7187 RNAseq 1.6939 0.0000
SRP064894 TRAF3 7187 RNAseq 0.8409 0.0000
SRP133303 TRAF3 7187 RNAseq 0.5861 0.0000
SRP159526 TRAF3 7187 RNAseq 0.7492 0.0088
SRP193095 TRAF3 7187 RNAseq 0.8092 0.0000
SRP219564 TRAF3 7187 RNAseq 0.5004 0.0249
TCGA TRAF3 7187 RNAseq 0.3165 0.0000

Upregulated datasets: 2; Downregulated datasets: 0.  

 

Survival by TRAF3 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of TRAF3:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 TRAF3 7187 12 4 14
GSE20123 TRAF3 7187 11 3 16
GSE43470 TRAF3 7187 6 4 33
GSE46452 TRAF3 7187 18 4 37
GSE47630 TRAF3 7187 10 9 21
GSE54993 TRAF3 7187 3 8 59
GSE54994 TRAF3 7187 21 4 28
GSE60625 TRAF3 7187 0 2 9
GSE74703 TRAF3 7187 5 3 28
GSE74704 TRAF3 7187 5 3 12
TCGA TRAF3 7187 31 21 44

Total number of gains: 122; Total number of losses: 65; Total Number of normals: 301.  

 

Somatic mutations of TRAF3:

 

Generating mutation plots.

 

Highly correlated genes for TRAF3:

 

Showing top 20/1694 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
TRAF3CDCA20.829828404
TRAF3ALG10.792494303
TRAF3TMTC40.775307303
TRAF3SPATA50.77059303
TRAF3SAAL10.764829404
TRAF3XPR10.752519505
TRAF3SEC22C0.751936303
TRAF3S1PR50.749843303
TRAF3ZC3HC10.744485404
TRAF3DMTF10.744311303
TRAF3SRGN0.739079303
TRAF3TMEM1380.738638605
TRAF3PSPC10.737342404
TRAF3MAN1A10.736498303
TRAF3C1orf2260.736445303
TRAF3NUDCD10.728904504
TRAF3DHX330.726997505
TRAF3NUP350.725341404
TRAF3SPNS10.723298303
TRAF3FAM200A0.72328303

For details and further investigation, click here