| Full name: VOPP1 WW domain binding protein | Alias Symbol: ECop|GASP|FLJ20532|DKFZp564K0822|WBP1L2 | ||
| Type: protein-coding gene | Cytoband: 7p11.2 | ||
| Entrez ID: 81552 | HGNC ID: HGNC:34518 | Ensembl Gene: ENSG00000154978 | OMIM ID: 611915 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of VOPP1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | VOPP1 | 81552 | 208091_s_at | 1.1083 | 0.0529 | |
| GSE20347 | VOPP1 | 81552 | 208091_s_at | 1.8242 | 0.0000 | |
| GSE23400 | VOPP1 | 81552 | 208091_s_at | 1.3904 | 0.0000 | |
| GSE26886 | VOPP1 | 81552 | 208091_s_at | 1.5737 | 0.0000 | |
| GSE29001 | VOPP1 | 81552 | 208091_s_at | 1.5368 | 0.0002 | |
| GSE38129 | VOPP1 | 81552 | 208091_s_at | 1.6059 | 0.0000 | |
| GSE45670 | VOPP1 | 81552 | 208091_s_at | 0.7694 | 0.0002 | |
| GSE53622 | VOPP1 | 81552 | 119835 | 1.2468 | 0.0000 | |
| GSE53624 | VOPP1 | 81552 | 119835 | 1.3055 | 0.0000 | |
| GSE63941 | VOPP1 | 81552 | 208091_s_at | -0.1394 | 0.8654 | |
| GSE77861 | VOPP1 | 81552 | 208091_s_at | 0.8077 | 0.0130 | |
| GSE97050 | VOPP1 | 81552 | A_23_P168211 | 1.1340 | 0.0684 | |
| SRP007169 | VOPP1 | 81552 | RNAseq | 2.1007 | 0.0000 | |
| SRP008496 | VOPP1 | 81552 | RNAseq | 2.7198 | 0.0000 | |
| SRP064894 | VOPP1 | 81552 | RNAseq | 1.6879 | 0.0000 | |
| SRP133303 | VOPP1 | 81552 | RNAseq | 1.1115 | 0.0000 | |
| SRP159526 | VOPP1 | 81552 | RNAseq | 1.1801 | 0.0007 | |
| SRP193095 | VOPP1 | 81552 | RNAseq | 0.9132 | 0.0000 | |
| SRP219564 | VOPP1 | 81552 | RNAseq | 1.1580 | 0.0011 | |
| TCGA | VOPP1 | 81552 | RNAseq | 0.1691 | 0.0417 |
Upregulated datasets: 13; Downregulated datasets: 0.
Survival by VOPP1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of VOPP1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | VOPP1 | 81552 | 13 | 0 | 17 | |
| GSE20123 | VOPP1 | 81552 | 11 | 0 | 19 | |
| GSE43470 | VOPP1 | 81552 | 5 | 0 | 38 | |
| GSE46452 | VOPP1 | 81552 | 13 | 0 | 46 | |
| GSE47630 | VOPP1 | 81552 | 10 | 1 | 29 | |
| GSE54993 | VOPP1 | 81552 | 0 | 10 | 60 | |
| GSE54994 | VOPP1 | 81552 | 18 | 1 | 34 | |
| GSE60625 | VOPP1 | 81552 | 0 | 0 | 11 | |
| GSE74703 | VOPP1 | 81552 | 5 | 0 | 31 | |
| GSE74704 | VOPP1 | 81552 | 6 | 0 | 14 | |
| TCGA | VOPP1 | 81552 | 56 | 5 | 35 |
Total number of gains: 137; Total number of losses: 17; Total Number of normals: 334.
Somatic mutations of VOPP1:
Generating mutation plots.
Highly correlated genes for VOPP1:
Showing top 20/2244 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| VOPP1 | WDR54 | 0.818284 | 7 | 0 | 7 |
| VOPP1 | MAN1A1 | 0.815055 | 3 | 0 | 3 |
| VOPP1 | XPR1 | 0.797655 | 7 | 0 | 7 |
| VOPP1 | ARPC1B | 0.78266 | 12 | 0 | 11 |
| VOPP1 | ALPK2 | 0.779125 | 3 | 0 | 3 |
| VOPP1 | PDE7A | 0.778889 | 7 | 0 | 7 |
| VOPP1 | CDCA2 | 0.761378 | 5 | 0 | 5 |
| VOPP1 | MFAP2 | 0.756248 | 11 | 0 | 11 |
| VOPP1 | KTI12 | 0.75537 | 3 | 0 | 3 |
| VOPP1 | DNMT1 | 0.75345 | 11 | 0 | 11 |
| VOPP1 | LAPTM4B | 0.752404 | 12 | 0 | 11 |
| VOPP1 | ADAR | 0.751692 | 10 | 0 | 10 |
| VOPP1 | GORAB | 0.751173 | 6 | 0 | 6 |
| VOPP1 | FMNL2 | 0.750992 | 7 | 0 | 7 |
| VOPP1 | SNX10 | 0.748897 | 11 | 0 | 10 |
| VOPP1 | LRRC8C | 0.7467 | 3 | 0 | 3 |
| VOPP1 | CDH11 | 0.746352 | 11 | 0 | 11 |
| VOPP1 | PDIA5 | 0.745252 | 3 | 0 | 3 |
| VOPP1 | TGFBR1 | 0.744329 | 3 | 0 | 3 |
| VOPP1 | ZNF628 | 0.743513 | 3 | 0 | 3 |
For details and further investigation, click here
