| Full name: mitogen-activated protein kinase kinase kinase 5 | Alias Symbol: MAPKKK5|ASK1 | ||
| Type: protein-coding gene | Cytoband: 6q23.3 | ||
| Entrez ID: 4217 | HGNC ID: HGNC:6857 | Ensembl Gene: ENSG00000197442 | OMIM ID: 602448 |
| Drug and gene relationship at DGIdb | |||
MAP3K5 involved pathways:
Expression of MAP3K5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MAP3K5 | 4217 | 203837_at | 0.4556 | 0.4456 | |
| GSE20347 | MAP3K5 | 4217 | 203837_at | -0.4556 | 0.0093 | |
| GSE23400 | MAP3K5 | 4217 | 203837_at | -0.0938 | 0.3408 | |
| GSE26886 | MAP3K5 | 4217 | 203837_at | -0.4619 | 0.1254 | |
| GSE29001 | MAP3K5 | 4217 | 203837_at | -0.0471 | 0.8631 | |
| GSE38129 | MAP3K5 | 4217 | 203837_at | -0.2417 | 0.1415 | |
| GSE45670 | MAP3K5 | 4217 | 203837_at | 0.1941 | 0.3511 | |
| GSE53622 | MAP3K5 | 4217 | 75145 | -0.2539 | 0.0006 | |
| GSE53624 | MAP3K5 | 4217 | 75145 | -0.3759 | 0.0003 | |
| GSE63941 | MAP3K5 | 4217 | 203837_at | -0.7194 | 0.3740 | |
| GSE77861 | MAP3K5 | 4217 | 203837_at | -0.1811 | 0.6385 | |
| GSE97050 | MAP3K5 | 4217 | A_23_P134125 | -0.1769 | 0.4409 | |
| SRP007169 | MAP3K5 | 4217 | RNAseq | -0.4250 | 0.3519 | |
| SRP008496 | MAP3K5 | 4217 | RNAseq | -0.6542 | 0.0102 | |
| SRP064894 | MAP3K5 | 4217 | RNAseq | -0.2835 | 0.3362 | |
| SRP133303 | MAP3K5 | 4217 | RNAseq | -0.1430 | 0.2588 | |
| SRP159526 | MAP3K5 | 4217 | RNAseq | -0.5500 | 0.2075 | |
| SRP193095 | MAP3K5 | 4217 | RNAseq | -0.4858 | 0.0028 | |
| SRP219564 | MAP3K5 | 4217 | RNAseq | 0.0503 | 0.8876 | |
| TCGA | MAP3K5 | 4217 | RNAseq | -0.2287 | 0.0008 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by MAP3K5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MAP3K5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MAP3K5 | 4217 | 4 | 4 | 22 | |
| GSE20123 | MAP3K5 | 4217 | 3 | 3 | 24 | |
| GSE43470 | MAP3K5 | 4217 | 5 | 0 | 38 | |
| GSE46452 | MAP3K5 | 4217 | 3 | 10 | 46 | |
| GSE47630 | MAP3K5 | 4217 | 9 | 4 | 27 | |
| GSE54993 | MAP3K5 | 4217 | 3 | 2 | 65 | |
| GSE54994 | MAP3K5 | 4217 | 9 | 7 | 37 | |
| GSE60625 | MAP3K5 | 4217 | 0 | 1 | 10 | |
| GSE74703 | MAP3K5 | 4217 | 4 | 0 | 32 | |
| GSE74704 | MAP3K5 | 4217 | 1 | 1 | 18 | |
| TCGA | MAP3K5 | 4217 | 12 | 17 | 67 |
Total number of gains: 53; Total number of losses: 49; Total Number of normals: 386.
Somatic mutations of MAP3K5:
Generating mutation plots.
Highly correlated genes for MAP3K5:
Showing top 20/168 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MAP3K5 | RAB42 | 0.705421 | 3 | 0 | 3 |
| MAP3K5 | PCMTD1 | 0.70035 | 3 | 0 | 3 |
| MAP3K5 | NAA15 | 0.696404 | 3 | 0 | 3 |
| MAP3K5 | CCNJ | 0.693052 | 3 | 0 | 3 |
| MAP3K5 | B4GALT5 | 0.691779 | 4 | 0 | 3 |
| MAP3K5 | COX19 | 0.686509 | 3 | 0 | 3 |
| MAP3K5 | AMBRA1 | 0.677894 | 3 | 0 | 3 |
| MAP3K5 | STK35 | 0.675436 | 3 | 0 | 3 |
| MAP3K5 | NBN | 0.671216 | 3 | 0 | 3 |
| MAP3K5 | EXOC2 | 0.670401 | 3 | 0 | 3 |
| MAP3K5 | GPBP1 | 0.668068 | 3 | 0 | 3 |
| MAP3K5 | ERAP1 | 0.666002 | 3 | 0 | 3 |
| MAP3K5 | RBMS1 | 0.664182 | 3 | 0 | 3 |
| MAP3K5 | REL | 0.660314 | 3 | 0 | 3 |
| MAP3K5 | QSER1 | 0.659471 | 4 | 0 | 4 |
| MAP3K5 | TRIM22 | 0.653424 | 4 | 0 | 4 |
| MAP3K5 | PPARGC1B | 0.651434 | 3 | 0 | 3 |
| MAP3K5 | ANKRD46 | 0.650464 | 4 | 0 | 3 |
| MAP3K5 | HDHD2 | 0.646776 | 4 | 0 | 3 |
| MAP3K5 | AKIP1 | 0.644829 | 3 | 0 | 3 |
For details and further investigation, click here
