| Full name: endoplasmic reticulum aminopeptidase 1 | Alias Symbol: ARTS-1|A-LAP|PILS-AP|KIAA0525|ERAAP1 | ||
| Type: protein-coding gene | Cytoband: 5q15 | ||
| Entrez ID: 51752 | HGNC ID: HGNC:18173 | Ensembl Gene: ENSG00000164307 | OMIM ID: 606832 |
| Drug and gene relationship at DGIdb | |||
Expression of ERAP1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ERAP1 | 51752 | 209788_s_at | 0.3150 | 0.5840 | |
| GSE20347 | ERAP1 | 51752 | 209788_s_at | -0.2315 | 0.3971 | |
| GSE23400 | ERAP1 | 51752 | 209788_s_at | 0.2848 | 0.0088 | |
| GSE26886 | ERAP1 | 51752 | 210385_s_at | 0.4442 | 0.3629 | |
| GSE29001 | ERAP1 | 51752 | 210385_s_at | 0.7454 | 0.0497 | |
| GSE38129 | ERAP1 | 51752 | 209788_s_at | -0.0572 | 0.7972 | |
| GSE45670 | ERAP1 | 51752 | 209788_s_at | 0.4366 | 0.1518 | |
| GSE53622 | ERAP1 | 51752 | 39631 | -0.7015 | 0.0007 | |
| GSE53624 | ERAP1 | 51752 | 39631 | -0.6250 | 0.0007 | |
| GSE63941 | ERAP1 | 51752 | 209788_s_at | 0.1691 | 0.8617 | |
| GSE77861 | ERAP1 | 51752 | 209788_s_at | 0.2339 | 0.6659 | |
| GSE97050 | ERAP1 | 51752 | A_33_P3413701 | -0.8350 | 0.0762 | |
| SRP007169 | ERAP1 | 51752 | RNAseq | 0.5762 | 0.2223 | |
| SRP008496 | ERAP1 | 51752 | RNAseq | 0.5393 | 0.1003 | |
| SRP064894 | ERAP1 | 51752 | RNAseq | 0.3202 | 0.1892 | |
| SRP133303 | ERAP1 | 51752 | RNAseq | 0.2917 | 0.1070 | |
| SRP159526 | ERAP1 | 51752 | RNAseq | 0.3718 | 0.3348 | |
| SRP193095 | ERAP1 | 51752 | RNAseq | -0.2888 | 0.0950 | |
| SRP219564 | ERAP1 | 51752 | RNAseq | 0.6013 | 0.2907 | |
| TCGA | ERAP1 | 51752 | RNAseq | -0.0513 | 0.4618 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ERAP1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ERAP1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ERAP1 | 51752 | 1 | 13 | 16 | |
| GSE20123 | ERAP1 | 51752 | 1 | 13 | 16 | |
| GSE43470 | ERAP1 | 51752 | 3 | 9 | 31 | |
| GSE46452 | ERAP1 | 51752 | 0 | 28 | 31 | |
| GSE47630 | ERAP1 | 51752 | 0 | 20 | 20 | |
| GSE54993 | ERAP1 | 51752 | 8 | 1 | 61 | |
| GSE54994 | ERAP1 | 51752 | 1 | 18 | 34 | |
| GSE60625 | ERAP1 | 51752 | 0 | 0 | 11 | |
| GSE74703 | ERAP1 | 51752 | 2 | 7 | 27 | |
| GSE74704 | ERAP1 | 51752 | 1 | 7 | 12 | |
| TCGA | ERAP1 | 51752 | 3 | 43 | 50 |
Total number of gains: 20; Total number of losses: 159; Total Number of normals: 309.
Somatic mutations of ERAP1:
Generating mutation plots.
Highly correlated genes for ERAP1:
Showing top 20/239 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ERAP1 | TTC17 | 0.723721 | 3 | 0 | 3 |
| ERAP1 | NOA1 | 0.706997 | 3 | 0 | 3 |
| ERAP1 | NUFIP2 | 0.703498 | 3 | 0 | 3 |
| ERAP1 | PDZD11 | 0.685509 | 3 | 0 | 3 |
| ERAP1 | MAP3K5 | 0.666002 | 3 | 0 | 3 |
| ERAP1 | FGL2 | 0.656492 | 3 | 0 | 3 |
| ERAP1 | DHRSX | 0.655458 | 3 | 0 | 3 |
| ERAP1 | ELP2 | 0.653762 | 3 | 0 | 3 |
| ERAP1 | SLC5A3 | 0.650598 | 3 | 0 | 3 |
| ERAP1 | CDC5L | 0.641423 | 4 | 0 | 4 |
| ERAP1 | LOXL4 | 0.636437 | 3 | 0 | 3 |
| ERAP1 | SLC25A40 | 0.635814 | 4 | 0 | 3 |
| ERAP1 | RNF166 | 0.635016 | 4 | 0 | 3 |
| ERAP1 | ORC5 | 0.632785 | 4 | 0 | 4 |
| ERAP1 | LRP4 | 0.629187 | 4 | 0 | 3 |
| ERAP1 | SCPEP1 | 0.629056 | 3 | 0 | 3 |
| ERAP1 | CEP70 | 0.628442 | 4 | 0 | 4 |
| ERAP1 | SNX25 | 0.625398 | 3 | 0 | 3 |
| ERAP1 | RAB11FIP2 | 0.616552 | 4 | 0 | 3 |
| ERAP1 | NDN | 0.615831 | 4 | 0 | 3 |
For details and further investigation, click here
