| Full name: PPARG coactivator 1 beta | Alias Symbol: PERC|PGC1B | ||
| Type: protein-coding gene | Cytoband: 5q32 | ||
| Entrez ID: 133522 | HGNC ID: HGNC:30022 | Ensembl Gene: ENSG00000155846 | OMIM ID: 608886 |
| Drug and gene relationship at DGIdb | |||
PPARGC1B involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04931 | Insulin resistance |
Expression of PPARGC1B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PPARGC1B | 133522 | 232181_at | 0.9398 | 0.0287 | |
| GSE26886 | PPARGC1B | 133522 | 232181_at | -1.2220 | 0.0004 | |
| GSE45670 | PPARGC1B | 133522 | 232181_at | -0.1601 | 0.5859 | |
| GSE53622 | PPARGC1B | 133522 | 42617 | -0.8173 | 0.0000 | |
| GSE53624 | PPARGC1B | 133522 | 42617 | -0.6181 | 0.0000 | |
| GSE63941 | PPARGC1B | 133522 | 232181_at | 1.4440 | 0.0405 | |
| GSE77861 | PPARGC1B | 133522 | 232181_at | 0.0227 | 0.9488 | |
| GSE97050 | PPARGC1B | 133522 | A_23_P213959 | -0.5323 | 0.2765 | |
| SRP007169 | PPARGC1B | 133522 | RNAseq | 0.0915 | 0.8759 | |
| SRP008496 | PPARGC1B | 133522 | RNAseq | -0.3910 | 0.2776 | |
| SRP064894 | PPARGC1B | 133522 | RNAseq | -0.6592 | 0.0196 | |
| SRP133303 | PPARGC1B | 133522 | RNAseq | -0.5072 | 0.0260 | |
| SRP159526 | PPARGC1B | 133522 | RNAseq | -0.3519 | 0.4226 | |
| SRP193095 | PPARGC1B | 133522 | RNAseq | -0.4346 | 0.0024 | |
| SRP219564 | PPARGC1B | 133522 | RNAseq | -0.3668 | 0.2160 | |
| TCGA | PPARGC1B | 133522 | RNAseq | -0.2982 | 0.0078 |
Upregulated datasets: 1; Downregulated datasets: 1.
Survival by PPARGC1B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PPARGC1B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PPARGC1B | 133522 | 1 | 12 | 17 | |
| GSE20123 | PPARGC1B | 133522 | 1 | 12 | 17 | |
| GSE43470 | PPARGC1B | 133522 | 1 | 10 | 32 | |
| GSE46452 | PPARGC1B | 133522 | 0 | 27 | 32 | |
| GSE47630 | PPARGC1B | 133522 | 0 | 20 | 20 | |
| GSE54993 | PPARGC1B | 133522 | 9 | 1 | 60 | |
| GSE54994 | PPARGC1B | 133522 | 2 | 15 | 36 | |
| GSE60625 | PPARGC1B | 133522 | 0 | 0 | 11 | |
| GSE74703 | PPARGC1B | 133522 | 1 | 7 | 28 | |
| GSE74704 | PPARGC1B | 133522 | 1 | 7 | 12 | |
| TCGA | PPARGC1B | 133522 | 5 | 38 | 53 |
Total number of gains: 21; Total number of losses: 149; Total Number of normals: 318.
Somatic mutations of PPARGC1B:
Generating mutation plots.
Highly correlated genes for PPARGC1B:
Showing top 20/152 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PPARGC1B | TP53RK | 0.773624 | 3 | 0 | 3 |
| PPARGC1B | EIF4H | 0.748582 | 3 | 0 | 3 |
| PPARGC1B | LGALSL | 0.735319 | 3 | 0 | 3 |
| PPARGC1B | SLC6A8 | 0.704207 | 3 | 0 | 3 |
| PPARGC1B | NUFIP2 | 0.703583 | 3 | 0 | 3 |
| PPARGC1B | DNAAF2 | 0.702747 | 3 | 0 | 3 |
| PPARGC1B | RNF149 | 0.697281 | 3 | 0 | 3 |
| PPARGC1B | DBT | 0.696085 | 3 | 0 | 3 |
| PPARGC1B | RPA1 | 0.68238 | 3 | 0 | 3 |
| PPARGC1B | HEXIM1 | 0.680536 | 3 | 0 | 3 |
| PPARGC1B | TBC1D14 | 0.680349 | 3 | 0 | 3 |
| PPARGC1B | AGL | 0.667029 | 3 | 0 | 3 |
| PPARGC1B | ARFGAP2 | 0.659802 | 3 | 0 | 3 |
| PPARGC1B | MAP3K5 | 0.651434 | 3 | 0 | 3 |
| PPARGC1B | VPS16 | 0.647511 | 3 | 0 | 3 |
| PPARGC1B | CRNKL1 | 0.645474 | 3 | 0 | 3 |
| PPARGC1B | GNG12 | 0.644606 | 3 | 0 | 3 |
| PPARGC1B | SS18L1 | 0.644194 | 3 | 0 | 3 |
| PPARGC1B | NFKBIZ | 0.6427 | 3 | 0 | 3 |
| PPARGC1B | AMMECR1 | 0.640222 | 3 | 0 | 3 |
For details and further investigation, click here
