| Full name: mitogen-activated protein kinase kinase kinase 6 | Alias Symbol: MAPKKK6|ASK2|MEKK6 | ||
| Type: protein-coding gene | Cytoband: 1p36.11 | ||
| Entrez ID: 9064 | HGNC ID: HGNC:6858 | Ensembl Gene: ENSG00000142733 | OMIM ID: 604468 |
| Drug and gene relationship at DGIdb | |||
MAP3K6 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04010 | MAPK signaling pathway |
Expression of MAP3K6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MAP3K6 | 9064 | 219278_at | -0.4556 | 0.3622 | |
| GSE20347 | MAP3K6 | 9064 | 219278_at | -0.7554 | 0.0002 | |
| GSE23400 | MAP3K6 | 9064 | 219278_at | -0.2358 | 0.0106 | |
| GSE26886 | MAP3K6 | 9064 | 219278_at | -0.6123 | 0.0742 | |
| GSE29001 | MAP3K6 | 9064 | 219278_at | -0.4522 | 0.2809 | |
| GSE38129 | MAP3K6 | 9064 | 219278_at | -0.5847 | 0.0002 | |
| GSE45670 | MAP3K6 | 9064 | 219278_at | -0.1822 | 0.3193 | |
| GSE53622 | MAP3K6 | 9064 | 20046 | -0.1016 | 0.1168 | |
| GSE53624 | MAP3K6 | 9064 | 111616 | -0.5864 | 0.0000 | |
| GSE63941 | MAP3K6 | 9064 | 219278_at | -0.8914 | 0.0647 | |
| GSE77861 | MAP3K6 | 9064 | 219278_at | -0.5141 | 0.0646 | |
| GSE97050 | MAP3K6 | 9064 | A_33_P3404418 | 0.0304 | 0.9022 | |
| SRP007169 | MAP3K6 | 9064 | RNAseq | -1.1912 | 0.0215 | |
| SRP008496 | MAP3K6 | 9064 | RNAseq | -1.2159 | 0.0000 | |
| SRP064894 | MAP3K6 | 9064 | RNAseq | 0.0913 | 0.6769 | |
| SRP133303 | MAP3K6 | 9064 | RNAseq | -0.5017 | 0.0452 | |
| SRP159526 | MAP3K6 | 9064 | RNAseq | -1.0869 | 0.0001 | |
| SRP193095 | MAP3K6 | 9064 | RNAseq | -0.3353 | 0.1421 | |
| SRP219564 | MAP3K6 | 9064 | RNAseq | -1.0114 | 0.0013 | |
| TCGA | MAP3K6 | 9064 | RNAseq | 0.0514 | 0.4700 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by MAP3K6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MAP3K6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MAP3K6 | 9064 | 0 | 6 | 24 | |
| GSE20123 | MAP3K6 | 9064 | 0 | 5 | 25 | |
| GSE43470 | MAP3K6 | 9064 | 4 | 6 | 33 | |
| GSE46452 | MAP3K6 | 9064 | 5 | 1 | 53 | |
| GSE47630 | MAP3K6 | 9064 | 8 | 3 | 29 | |
| GSE54993 | MAP3K6 | 9064 | 2 | 1 | 67 | |
| GSE54994 | MAP3K6 | 9064 | 10 | 4 | 39 | |
| GSE60625 | MAP3K6 | 9064 | 0 | 0 | 11 | |
| GSE74703 | MAP3K6 | 9064 | 3 | 4 | 29 | |
| GSE74704 | MAP3K6 | 9064 | 0 | 0 | 20 | |
| TCGA | MAP3K6 | 9064 | 11 | 24 | 61 |
Total number of gains: 43; Total number of losses: 54; Total Number of normals: 391.
Somatic mutations of MAP3K6:
Generating mutation plots.
Highly correlated genes for MAP3K6:
Showing top 20/139 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MAP3K6 | TLCD2 | 0.70656 | 4 | 0 | 3 |
| MAP3K6 | GJD4 | 0.695592 | 3 | 0 | 3 |
| MAP3K6 | KIRREL2 | 0.673965 | 3 | 0 | 3 |
| MAP3K6 | LRFN3 | 0.667317 | 4 | 0 | 3 |
| MAP3K6 | KCNK12 | 0.666326 | 3 | 0 | 3 |
| MAP3K6 | FXYD2 | 0.660318 | 3 | 0 | 3 |
| MAP3K6 | DUOXA2 | 0.656424 | 4 | 0 | 4 |
| MAP3K6 | TNR | 0.645052 | 5 | 0 | 3 |
| MAP3K6 | ANKDD1A | 0.642914 | 4 | 0 | 3 |
| MAP3K6 | ETFB | 0.639033 | 3 | 0 | 3 |
| MAP3K6 | KCP | 0.636142 | 5 | 0 | 5 |
| MAP3K6 | PPM1N | 0.632704 | 3 | 0 | 3 |
| MAP3K6 | DNASE1 | 0.629166 | 4 | 0 | 4 |
| MAP3K6 | TNFRSF14 | 0.627975 | 5 | 0 | 3 |
| MAP3K6 | MAST4 | 0.620889 | 9 | 0 | 6 |
| MAP3K6 | ANKRD33 | 0.620021 | 4 | 0 | 3 |
| MAP3K6 | KRTAP2-1 | 0.612702 | 4 | 0 | 3 |
| MAP3K6 | LARP4B | 0.611334 | 5 | 0 | 3 |
| MAP3K6 | ABCD3 | 0.606483 | 5 | 0 | 3 |
| MAP3K6 | REEP6 | 0.603429 | 4 | 0 | 4 |
For details and further investigation, click here
