| Full name: TLC domain containing 2 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 17p13.3 | ||
| Entrez ID: 727910 | HGNC ID: HGNC:33522 | Ensembl Gene: ENSG00000185561 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of TLCD2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TLCD2 | 727910 | 241359_at | -0.6057 | 0.5327 | |
| GSE26886 | TLCD2 | 727910 | 241359_at | -0.8606 | 0.0264 | |
| GSE45670 | TLCD2 | 727910 | 241359_at | 0.0630 | 0.8675 | |
| GSE53622 | TLCD2 | 727910 | 38105 | -0.5573 | 0.0000 | |
| GSE53624 | TLCD2 | 727910 | 38105 | -0.4584 | 0.0000 | |
| GSE63941 | TLCD2 | 727910 | 241359_at | -1.6594 | 0.0600 | |
| GSE77861 | TLCD2 | 727910 | 241359_at | -0.4515 | 0.0782 | |
| GSE97050 | TLCD2 | 727910 | A_33_P3345210 | 0.0909 | 0.7200 | |
| SRP007169 | TLCD2 | 727910 | RNAseq | -0.5883 | 0.2230 | |
| SRP008496 | TLCD2 | 727910 | RNAseq | -0.2641 | 0.4440 | |
| SRP064894 | TLCD2 | 727910 | RNAseq | -0.2908 | 0.1569 | |
| SRP133303 | TLCD2 | 727910 | RNAseq | -0.5574 | 0.0000 | |
| SRP159526 | TLCD2 | 727910 | RNAseq | -0.6055 | 0.0733 | |
| SRP193095 | TLCD2 | 727910 | RNAseq | -0.5856 | 0.0000 | |
| SRP219564 | TLCD2 | 727910 | RNAseq | -0.4925 | 0.2811 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by TLCD2 expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of TLCD2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TLCD2 | 727910 | 5 | 2 | 23 | |
| GSE20123 | TLCD2 | 727910 | 5 | 3 | 22 | |
| GSE43470 | TLCD2 | 727910 | 3 | 6 | 34 | |
| GSE46452 | TLCD2 | 727910 | 34 | 1 | 24 | |
| GSE47630 | TLCD2 | 727910 | 8 | 1 | 31 | |
| GSE54993 | TLCD2 | 727910 | 9 | 3 | 58 | |
| GSE54994 | TLCD2 | 727910 | 8 | 8 | 37 | |
| GSE60625 | TLCD2 | 727910 | 4 | 0 | 7 | |
| GSE74703 | TLCD2 | 727910 | 2 | 3 | 31 | |
| GSE74704 | TLCD2 | 727910 | 3 | 1 | 16 | |
| TCGA | TLCD2 | 727910 | 20 | 21 | 55 |
Total number of gains: 101; Total number of losses: 49; Total Number of normals: 338.
Somatic mutations of TLCD2:
Generating mutation plots.
Highly correlated genes for TLCD2:
Showing top 20/206 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TLCD2 | MAP3K6 | 0.70656 | 4 | 0 | 3 |
| TLCD2 | CNDP2 | 0.702542 | 3 | 0 | 3 |
| TLCD2 | FBF1 | 0.696057 | 3 | 0 | 3 |
| TLCD2 | RXFP3 | 0.660378 | 3 | 0 | 3 |
| TLCD2 | SLC22A25 | 0.648086 | 3 | 0 | 3 |
| TLCD2 | MAST4 | 0.646796 | 6 | 0 | 5 |
| TLCD2 | ANXA11 | 0.645628 | 4 | 0 | 4 |
| TLCD2 | NSG1 | 0.644909 | 4 | 0 | 3 |
| TLCD2 | DLK2 | 0.643783 | 3 | 0 | 3 |
| TLCD2 | MAPKAPK3 | 0.642385 | 5 | 0 | 4 |
| TLCD2 | ITM2B | 0.636722 | 5 | 0 | 3 |
| TLCD2 | SFTPB | 0.624099 | 3 | 0 | 3 |
| TLCD2 | PPIC | 0.622422 | 6 | 0 | 4 |
| TLCD2 | RPIA | 0.617563 | 3 | 0 | 3 |
| TLCD2 | EML2 | 0.617094 | 4 | 0 | 4 |
| TLCD2 | SLC37A2 | 0.613265 | 4 | 0 | 4 |
| TLCD2 | REEP6 | 0.612572 | 4 | 0 | 4 |
| TLCD2 | CALML3 | 0.610647 | 4 | 0 | 3 |
| TLCD2 | NIPAL2 | 0.60536 | 5 | 0 | 3 |
| TLCD2 | PAFAH1B1 | 0.603966 | 4 | 0 | 3 |
For details and further investigation, click here
