MAPK14

 

Full name: mitogen-activated protein kinase 14 Alias Symbol: PRKM14|p38|Mxi2|PRKM15
Type: protein-coding gene Cytoband: 6p21.31
Entrez ID: 1432 HGNC ID: HGNC:6876 Ensembl Gene: ENSG00000112062 OMIM ID: 600289
Drug and gene relationship at DGIdb
Screen Evidence:

 

MAPK14 involved pathways:

KEGG pathway Description View
hsa04010MAPK signaling pathway
hsa04015Rap1 signaling pathway
hsa04068FoxO signaling pathway
hsa04071Sphingolipid signaling pathway
hsa04261Adrenergic signaling in cardiomyocytes
hsa04370VEGF signaling pathway
hsa04380Osteoclast differentiation
hsa04550Signaling pathways regulating pluripotency of stem cells
hsa04611Platelet activation
hsa04620Toll-like receptor signaling pathway
hsa04621NOD-like receptor signaling pathway
hsa04622RIG-I-like receptor signaling pathway
hsa04660T cell receptor signaling pathway
hsa04664Fc epsilon RI signaling pathway
hsa04668TNF signaling pathway
hsa04670Leukocyte transendothelial migration
hsa04722Neurotrophin signaling pathway
hsa04723Retrograde endocannabinoid signaling
hsa04728Dopaminergic synapse
hsa04750Inflammatory mediator regulation of TRP channels
hsa04912GnRH signaling pathway
hsa04914Progesterone-mediated oocyte maturation
hsa04917Prolactin signaling pathway
hsa04933AGE-RAGE signaling pathway in diabetic complications
hsa05014Amyotrophic lateral sclerosis (ALS)
hsa05120Epithelial cell signaling in Helicobacter pylori infection
hsa05131Shigellosis
hsa05132Salmonella infection
hsa05133Pertussis
hsa05140Leishmaniasis
hsa05142Chagas disease (American trypanosomiasis)
hsa05145Toxoplasmosis
hsa05152Tuberculosis
hsa05160Hepatitis C
hsa05164Influenza A
hsa05169Epstein-Barr virus infection
hsa05205Proteoglycans in cancer

 

Expression of MAPK14:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 MAPK14 1432 202530_at 0.0698 0.8214
GSE20347 MAPK14 1432 202530_at -0.3435 0.0012
GSE23400 MAPK14 1432 202530_at -0.0611 0.2391
GSE26886 MAPK14 1432 202530_at -0.8687 0.0002
GSE29001 MAPK14 1432 202530_at -0.1731 0.2730
GSE38129 MAPK14 1432 202530_at -0.3176 0.0001
GSE45670 MAPK14 1432 202530_at -0.0559 0.6637
GSE53622 MAPK14 1432 147336 -0.4541 0.0000
GSE53624 MAPK14 1432 147336 -0.7213 0.0000
GSE63941 MAPK14 1432 202530_at -0.5885 0.0826
GSE77861 MAPK14 1432 202530_at -0.3498 0.0909
GSE97050 MAPK14 1432 A_24_P283288 -0.0284 0.9301
SRP007169 MAPK14 1432 RNAseq -1.0352 0.0049
SRP008496 MAPK14 1432 RNAseq -0.9060 0.0000
SRP064894 MAPK14 1432 RNAseq -0.0964 0.4861
SRP133303 MAPK14 1432 RNAseq -0.2995 0.0052
SRP159526 MAPK14 1432 RNAseq -0.2336 0.3583
SRP193095 MAPK14 1432 RNAseq -0.4516 0.0000
SRP219564 MAPK14 1432 RNAseq -0.2193 0.2658
TCGA MAPK14 1432 RNAseq -0.0386 0.3965

Upregulated datasets: 0; Downregulated datasets: 1.  

 

Survival by MAPK14 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of MAPK14:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 MAPK14 1432 5 0 25
GSE20123 MAPK14 1432 5 0 25
GSE43470 MAPK14 1432 5 1 37
GSE46452 MAPK14 1432 2 9 48
GSE47630 MAPK14 1432 8 4 28
GSE54993 MAPK14 1432 3 1 66
GSE54994 MAPK14 1432 11 4 38
GSE60625 MAPK14 1432 1 0 10
GSE74703 MAPK14 1432 5 0 31
GSE74704 MAPK14 1432 2 0 18
TCGA MAPK14 1432 15 15 66

Total number of gains: 62; Total number of losses: 34; Total Number of normals: 392.  

 

Somatic mutations of MAPK14:

 

Generating mutation plots.

 

Highly correlated genes for MAPK14:

 

Showing top 20/565 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
MAPK14ABHD16A0.752203303
MAPK14FAM214A0.687834404
MAPK14EPGN0.687488303
MAPK14CAPN140.68624404
MAPK14SPINK70.682185404
MAPK14ARID4A0.674102303
MAPK14OMA10.670117303
MAPK14OR2Z10.669867303
MAPK14TTC220.668256505
MAPK14MUC150.668222404
MAPK14ATP13A40.663995505
MAPK14ANKRD310.661288303
MAPK14SERPINB60.656775706
MAPK14C15orf480.654992505
MAPK14BTBD90.653494504
MAPK14NPRL20.652253404
MAPK14KLHL100.651213303
MAPK14ZNF4310.649558303
MAPK14ZBTB10.647884403
MAPK14STK390.64784706

For details and further investigation, click here