| Full name: serine/threonine kinase 39 | Alias Symbol: DCHT|SPAK | ||
| Type: protein-coding gene | Cytoband: 2q24.3 | ||
| Entrez ID: 27347 | HGNC ID: HGNC:17717 | Ensembl Gene: ENSG00000198648 | OMIM ID: 607648 |
| Drug and gene relationship at DGIdb | |||
Expression of STK39:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | STK39 | 27347 | 202786_at | -0.8727 | 0.0998 | |
| GSE20347 | STK39 | 27347 | 202786_at | -1.8300 | 0.0000 | |
| GSE23400 | STK39 | 27347 | 202786_at | -1.4882 | 0.0000 | |
| GSE26886 | STK39 | 27347 | 202786_at | -1.6570 | 0.0000 | |
| GSE29001 | STK39 | 27347 | 202786_at | -1.8364 | 0.0001 | |
| GSE38129 | STK39 | 27347 | 202786_at | -1.4753 | 0.0000 | |
| GSE45670 | STK39 | 27347 | 202786_at | -1.0461 | 0.0064 | |
| GSE53622 | STK39 | 27347 | 32683 | -1.4701 | 0.0000 | |
| GSE53624 | STK39 | 27347 | 32683 | -1.8030 | 0.0000 | |
| GSE63941 | STK39 | 27347 | 202786_at | -0.9657 | 0.2686 | |
| GSE77861 | STK39 | 27347 | 202786_at | -1.6593 | 0.0010 | |
| GSE97050 | STK39 | 27347 | A_24_P19544 | -1.2215 | 0.0594 | |
| SRP007169 | STK39 | 27347 | RNAseq | -2.5315 | 0.0001 | |
| SRP008496 | STK39 | 27347 | RNAseq | -2.8235 | 0.0000 | |
| SRP064894 | STK39 | 27347 | RNAseq | -2.0494 | 0.0000 | |
| SRP133303 | STK39 | 27347 | RNAseq | -0.9076 | 0.0001 | |
| SRP159526 | STK39 | 27347 | RNAseq | -1.9805 | 0.0000 | |
| SRP193095 | STK39 | 27347 | RNAseq | -1.5263 | 0.0000 | |
| SRP219564 | STK39 | 27347 | RNAseq | -1.4665 | 0.0015 | |
| TCGA | STK39 | 27347 | RNAseq | -0.3552 | 0.0001 |
Upregulated datasets: 0; Downregulated datasets: 15.
Survival by STK39 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of STK39:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | STK39 | 27347 | 6 | 0 | 24 | |
| GSE20123 | STK39 | 27347 | 6 | 0 | 24 | |
| GSE43470 | STK39 | 27347 | 5 | 1 | 37 | |
| GSE46452 | STK39 | 27347 | 1 | 4 | 54 | |
| GSE47630 | STK39 | 27347 | 5 | 3 | 32 | |
| GSE54993 | STK39 | 27347 | 0 | 5 | 65 | |
| GSE54994 | STK39 | 27347 | 11 | 2 | 40 | |
| GSE60625 | STK39 | 27347 | 0 | 3 | 8 | |
| GSE74703 | STK39 | 27347 | 4 | 1 | 31 | |
| GSE74704 | STK39 | 27347 | 3 | 0 | 17 | |
| TCGA | STK39 | 27347 | 25 | 9 | 62 |
Total number of gains: 66; Total number of losses: 28; Total Number of normals: 394.
Somatic mutations of STK39:
Generating mutation plots.
Highly correlated genes for STK39:
Showing top 20/1866 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| STK39 | CGNL1 | 0.817476 | 7 | 0 | 7 |
| STK39 | UBL3 | 0.814858 | 10 | 0 | 10 |
| STK39 | KAT2B | 0.810329 | 11 | 0 | 11 |
| STK39 | KIAA0232 | 0.80841 | 10 | 0 | 10 |
| STK39 | HPGD | 0.804097 | 11 | 0 | 11 |
| STK39 | SCNN1B | 0.801222 | 10 | 0 | 10 |
| STK39 | SHROOM3 | 0.800937 | 7 | 0 | 7 |
| STK39 | NUCB2 | 0.798937 | 11 | 0 | 11 |
| STK39 | HDHD2 | 0.798133 | 5 | 0 | 5 |
| STK39 | FCHO2 | 0.797339 | 7 | 0 | 6 |
| STK39 | RBM20 | 0.79152 | 5 | 0 | 5 |
| STK39 | SNORA68 | 0.790284 | 4 | 0 | 4 |
| STK39 | RAB11A | 0.789797 | 10 | 0 | 10 |
| STK39 | CYP2J2 | 0.789327 | 10 | 0 | 10 |
| STK39 | BLNK | 0.786025 | 11 | 0 | 11 |
| STK39 | SORT1 | 0.784646 | 11 | 0 | 11 |
| STK39 | PLEKHA7 | 0.782925 | 7 | 0 | 7 |
| STK39 | LRRFIP2 | 0.781907 | 11 | 0 | 11 |
| STK39 | GYS2 | 0.781462 | 10 | 0 | 10 |
| STK39 | CA13 | 0.781001 | 3 | 0 | 3 |
For details and further investigation, click here
