| Full name: microtubule associated protein RP/EB family member 1 | Alias Symbol: EB1 | ||
| Type: protein-coding gene | Cytoband: 20q11.21 | ||
| Entrez ID: 22919 | HGNC ID: HGNC:6890 | Ensembl Gene: ENSG00000101367 | OMIM ID: 603108 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of MAPRE1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MAPRE1 | 22919 | 200713_s_at | 0.5623 | 0.2011 | |
| GSE20347 | MAPRE1 | 22919 | 200713_s_at | 0.3871 | 0.0102 | |
| GSE23400 | MAPRE1 | 22919 | 200713_s_at | 0.4433 | 0.0000 | |
| GSE26886 | MAPRE1 | 22919 | 200713_s_at | -0.3160 | 0.0331 | |
| GSE29001 | MAPRE1 | 22919 | 200713_s_at | 0.6949 | 0.0016 | |
| GSE38129 | MAPRE1 | 22919 | 200713_s_at | 0.3765 | 0.0047 | |
| GSE45670 | MAPRE1 | 22919 | 200713_s_at | 0.2690 | 0.1219 | |
| GSE53622 | MAPRE1 | 22919 | 30062 | 0.2041 | 0.0015 | |
| GSE53624 | MAPRE1 | 22919 | 30062 | 0.4343 | 0.0000 | |
| GSE63941 | MAPRE1 | 22919 | 200713_s_at | 0.7012 | 0.0527 | |
| GSE77861 | MAPRE1 | 22919 | 200713_s_at | 0.6488 | 0.0479 | |
| GSE97050 | MAPRE1 | 22919 | A_24_P220058 | 0.0071 | 0.9898 | |
| SRP007169 | MAPRE1 | 22919 | RNAseq | 0.3305 | 0.3453 | |
| SRP008496 | MAPRE1 | 22919 | RNAseq | 0.4567 | 0.0277 | |
| SRP064894 | MAPRE1 | 22919 | RNAseq | 0.5928 | 0.0063 | |
| SRP133303 | MAPRE1 | 22919 | RNAseq | 0.5514 | 0.0000 | |
| SRP159526 | MAPRE1 | 22919 | RNAseq | 0.2595 | 0.3424 | |
| SRP193095 | MAPRE1 | 22919 | RNAseq | 0.3482 | 0.0008 | |
| SRP219564 | MAPRE1 | 22919 | RNAseq | 0.0845 | 0.8351 | |
| TCGA | MAPRE1 | 22919 | RNAseq | 0.1075 | 0.0127 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by MAPRE1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MAPRE1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MAPRE1 | 22919 | 15 | 0 | 15 | |
| GSE20123 | MAPRE1 | 22919 | 15 | 0 | 15 | |
| GSE43470 | MAPRE1 | 22919 | 12 | 0 | 31 | |
| GSE46452 | MAPRE1 | 22919 | 29 | 0 | 30 | |
| GSE47630 | MAPRE1 | 22919 | 24 | 1 | 15 | |
| GSE54993 | MAPRE1 | 22919 | 0 | 18 | 52 | |
| GSE54994 | MAPRE1 | 22919 | 26 | 1 | 26 | |
| GSE60625 | MAPRE1 | 22919 | 0 | 0 | 11 | |
| GSE74703 | MAPRE1 | 22919 | 11 | 0 | 25 | |
| GSE74704 | MAPRE1 | 22919 | 10 | 0 | 10 | |
| TCGA | MAPRE1 | 22919 | 50 | 1 | 45 |
Total number of gains: 192; Total number of losses: 21; Total Number of normals: 275.
Somatic mutations of MAPRE1:
Generating mutation plots.
Highly correlated genes for MAPRE1:
Showing top 20/783 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MAPRE1 | IRF1 | 0.709968 | 3 | 0 | 3 |
| MAPRE1 | GTF2B | 0.703151 | 3 | 0 | 3 |
| MAPRE1 | ADAMDEC1 | 0.70087 | 3 | 0 | 3 |
| MAPRE1 | ACSS2 | 0.7 | 3 | 0 | 3 |
| MAPRE1 | CRLS1 | 0.695871 | 5 | 0 | 5 |
| MAPRE1 | SFR1 | 0.695688 | 3 | 0 | 3 |
| MAPRE1 | RLIM | 0.694834 | 3 | 0 | 3 |
| MAPRE1 | CERCAM | 0.693597 | 3 | 0 | 3 |
| MAPRE1 | RPL37A | 0.688163 | 3 | 0 | 3 |
| MAPRE1 | RSPRY1 | 0.683262 | 3 | 0 | 3 |
| MAPRE1 | YWHAH | 0.676157 | 10 | 0 | 9 |
| MAPRE1 | AEBP2 | 0.672442 | 3 | 0 | 3 |
| MAPRE1 | ZNF343 | 0.669081 | 4 | 0 | 4 |
| MAPRE1 | TMEM230 | 0.664754 | 8 | 0 | 7 |
| MAPRE1 | USP14 | 0.664111 | 6 | 0 | 5 |
| MAPRE1 | THAP11 | 0.662 | 5 | 0 | 5 |
| MAPRE1 | RAB21 | 0.661344 | 3 | 0 | 3 |
| MAPRE1 | CD44 | 0.661245 | 4 | 0 | 3 |
| MAPRE1 | ZFP91 | 0.661227 | 3 | 0 | 3 |
| MAPRE1 | ZDHHC4 | 0.659676 | 5 | 0 | 4 |
For details and further investigation, click here
