| Full name: general transcription factor IIB | Alias Symbol: TFIIB | ||
| Type: protein-coding gene | Cytoband: 1p22.2 | ||
| Entrez ID: 2959 | HGNC ID: HGNC:4648 | Ensembl Gene: ENSG00000137947 | OMIM ID: 189963 |
| Drug and gene relationship at DGIdb | |||
Expression of GTF2B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GTF2B | 2959 | 208066_s_at | -0.1823 | 0.7058 | |
| GSE20347 | GTF2B | 2959 | 208066_s_at | -0.4573 | 0.0073 | |
| GSE23400 | GTF2B | 2959 | 208066_s_at | -0.1527 | 0.0396 | |
| GSE26886 | GTF2B | 2959 | 208066_s_at | -0.6392 | 0.0019 | |
| GSE29001 | GTF2B | 2959 | 208066_s_at | -0.2024 | 0.3702 | |
| GSE38129 | GTF2B | 2959 | 208066_s_at | -0.3018 | 0.0391 | |
| GSE45670 | GTF2B | 2959 | 208066_s_at | -0.0847 | 0.5116 | |
| GSE53622 | GTF2B | 2959 | 1220 | -0.1972 | 0.0009 | |
| GSE53624 | GTF2B | 2959 | 1220 | -0.2295 | 0.0001 | |
| GSE63941 | GTF2B | 2959 | 208066_s_at | 0.2968 | 0.5395 | |
| GSE77861 | GTF2B | 2959 | 208066_s_at | -0.5543 | 0.0426 | |
| GSE97050 | GTF2B | 2959 | A_23_P34628 | -0.1265 | 0.6361 | |
| SRP007169 | GTF2B | 2959 | RNAseq | -1.4009 | 0.0004 | |
| SRP008496 | GTF2B | 2959 | RNAseq | -1.3880 | 0.0000 | |
| SRP064894 | GTF2B | 2959 | RNAseq | -0.5539 | 0.0000 | |
| SRP133303 | GTF2B | 2959 | RNAseq | -0.0203 | 0.9120 | |
| SRP159526 | GTF2B | 2959 | RNAseq | -0.7656 | 0.0000 | |
| SRP193095 | GTF2B | 2959 | RNAseq | -0.4354 | 0.0228 | |
| SRP219564 | GTF2B | 2959 | RNAseq | -0.5981 | 0.0207 | |
| TCGA | GTF2B | 2959 | RNAseq | -0.0146 | 0.7878 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by GTF2B expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GTF2B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GTF2B | 2959 | 0 | 8 | 22 | |
| GSE20123 | GTF2B | 2959 | 0 | 8 | 22 | |
| GSE43470 | GTF2B | 2959 | 2 | 4 | 37 | |
| GSE46452 | GTF2B | 2959 | 1 | 1 | 57 | |
| GSE47630 | GTF2B | 2959 | 8 | 5 | 27 | |
| GSE54993 | GTF2B | 2959 | 0 | 1 | 69 | |
| GSE54994 | GTF2B | 2959 | 6 | 2 | 45 | |
| GSE60625 | GTF2B | 2959 | 0 | 0 | 11 | |
| GSE74703 | GTF2B | 2959 | 1 | 3 | 32 | |
| GSE74704 | GTF2B | 2959 | 0 | 5 | 15 | |
| TCGA | GTF2B | 2959 | 6 | 23 | 67 |
Total number of gains: 24; Total number of losses: 60; Total Number of normals: 404.
Somatic mutations of GTF2B:
Generating mutation plots.
Highly correlated genes for GTF2B:
Showing top 20/699 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GTF2B | POLR2C | 0.824471 | 3 | 0 | 3 |
| GTF2B | TBC1D20 | 0.765481 | 3 | 0 | 3 |
| GTF2B | ZRANB1 | 0.764779 | 3 | 0 | 3 |
| GTF2B | MTUS1 | 0.762099 | 3 | 0 | 3 |
| GTF2B | TMOD2 | 0.761748 | 3 | 0 | 3 |
| GTF2B | SDCBP | 0.761041 | 3 | 0 | 3 |
| GTF2B | BLOC1S2 | 0.749909 | 3 | 0 | 3 |
| GTF2B | TRAPPC6B | 0.742846 | 3 | 0 | 3 |
| GTF2B | ZNF844 | 0.740287 | 3 | 0 | 3 |
| GTF2B | LEPROT | 0.728757 | 5 | 0 | 5 |
| GTF2B | FAM83D | 0.721461 | 4 | 0 | 4 |
| GTF2B | PPM1A | 0.719747 | 4 | 0 | 4 |
| GTF2B | GPBP1 | 0.719531 | 3 | 0 | 3 |
| GTF2B | NPTN | 0.719379 | 3 | 0 | 3 |
| GTF2B | SNX13 | 0.717058 | 4 | 0 | 4 |
| GTF2B | BDH2 | 0.716907 | 3 | 0 | 3 |
| GTF2B | ARHGAP5 | 0.7141 | 3 | 0 | 3 |
| GTF2B | AP3M1 | 0.709153 | 3 | 0 | 3 |
| GTF2B | MAPRE1 | 0.703151 | 3 | 0 | 3 |
| GTF2B | MTX3 | 0.70231 | 3 | 0 | 3 |
For details and further investigation, click here
