| Full name: methionine adenosyltransferase 2A | Alias Symbol: SAMS2|MATA2|MATII | ||
| Type: protein-coding gene | Cytoband: 2p11.2 | ||
| Entrez ID: 4144 | HGNC ID: HGNC:6904 | Ensembl Gene: ENSG00000168906 | OMIM ID: 601468 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of MAT2A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MAT2A | 4144 | 200768_s_at | -0.0462 | 0.9479 | |
| GSE20347 | MAT2A | 4144 | 200768_s_at | 0.1215 | 0.5098 | |
| GSE23400 | MAT2A | 4144 | 200768_s_at | -0.0296 | 0.7287 | |
| GSE26886 | MAT2A | 4144 | 200768_s_at | 0.2581 | 0.1450 | |
| GSE29001 | MAT2A | 4144 | 200768_s_at | -0.0856 | 0.7604 | |
| GSE38129 | MAT2A | 4144 | 200768_s_at | 0.0768 | 0.6362 | |
| GSE45670 | MAT2A | 4144 | 200768_s_at | 0.0592 | 0.7808 | |
| GSE53622 | MAT2A | 4144 | 39556 | -0.1024 | 0.2425 | |
| GSE53624 | MAT2A | 4144 | 36617 | -0.1332 | 0.0436 | |
| GSE63941 | MAT2A | 4144 | 200768_s_at | -0.2847 | 0.2257 | |
| GSE77861 | MAT2A | 4144 | 200768_s_at | 0.1103 | 0.6582 | |
| GSE97050 | MAT2A | 4144 | A_33_P3403044 | -0.0860 | 0.8624 | |
| SRP007169 | MAT2A | 4144 | RNAseq | -0.3312 | 0.4671 | |
| SRP008496 | MAT2A | 4144 | RNAseq | -0.1115 | 0.6938 | |
| SRP064894 | MAT2A | 4144 | RNAseq | -0.8611 | 0.0005 | |
| SRP133303 | MAT2A | 4144 | RNAseq | -0.0820 | 0.5828 | |
| SRP159526 | MAT2A | 4144 | RNAseq | -0.1692 | 0.6011 | |
| SRP193095 | MAT2A | 4144 | RNAseq | 0.0199 | 0.8496 | |
| SRP219564 | MAT2A | 4144 | RNAseq | -0.3050 | 0.4665 | |
| TCGA | MAT2A | 4144 | RNAseq | -0.2343 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by MAT2A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MAT2A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MAT2A | 4144 | 9 | 2 | 19 | |
| GSE20123 | MAT2A | 4144 | 9 | 2 | 19 | |
| GSE43470 | MAT2A | 4144 | 6 | 2 | 35 | |
| GSE46452 | MAT2A | 4144 | 2 | 3 | 54 | |
| GSE47630 | MAT2A | 4144 | 7 | 0 | 33 | |
| GSE54993 | MAT2A | 4144 | 0 | 6 | 64 | |
| GSE54994 | MAT2A | 4144 | 10 | 0 | 43 | |
| GSE60625 | MAT2A | 4144 | 0 | 3 | 8 | |
| GSE74703 | MAT2A | 4144 | 5 | 1 | 30 | |
| GSE74704 | MAT2A | 4144 | 7 | 0 | 13 | |
| TCGA | MAT2A | 4144 | 35 | 3 | 58 |
Total number of gains: 90; Total number of losses: 22; Total Number of normals: 376.
Somatic mutations of MAT2A:
Generating mutation plots.
Highly correlated genes for MAT2A:
Showing top 20/43 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MAT2A | CYBRD1 | 0.698977 | 3 | 0 | 3 |
| MAT2A | JUND | 0.645156 | 4 | 0 | 3 |
| MAT2A | C5orf24 | 0.634078 | 3 | 0 | 3 |
| MAT2A | FBXO30 | 0.631564 | 3 | 0 | 3 |
| MAT2A | KIF3A | 0.621345 | 3 | 0 | 3 |
| MAT2A | ZBTB43 | 0.614563 | 3 | 0 | 3 |
| MAT2A | FNIP1 | 0.612558 | 3 | 0 | 3 |
| MAT2A | CDC16 | 0.607588 | 3 | 0 | 3 |
| MAT2A | DDX59 | 0.606567 | 3 | 0 | 3 |
| MAT2A | ZNF322 | 0.602527 | 3 | 0 | 3 |
| MAT2A | ARF1 | 0.598913 | 3 | 0 | 3 |
| MAT2A | LPGAT1 | 0.59643 | 3 | 0 | 3 |
| MAT2A | CCNL1 | 0.591795 | 5 | 0 | 4 |
| MAT2A | SHPRH | 0.591079 | 4 | 0 | 3 |
| MAT2A | C9orf64 | 0.590201 | 3 | 0 | 3 |
| MAT2A | LIG3 | 0.588963 | 4 | 0 | 3 |
| MAT2A | PHRF1 | 0.578313 | 4 | 0 | 3 |
| MAT2A | ZNF300 | 0.571554 | 3 | 0 | 3 |
| MAT2A | SLC25A29 | 0.571423 | 3 | 0 | 3 |
| MAT2A | SLC22A3 | 0.570199 | 3 | 0 | 3 |
For details and further investigation, click here
