| Full name: pterin-4 alpha-carbinolamine dehydratase 1 | Alias Symbol: PCD | ||
| Type: protein-coding gene | Cytoband: 10q22.1 | ||
| Entrez ID: 5092 | HGNC ID: HGNC:8646 | Ensembl Gene: ENSG00000166228 | OMIM ID: 126090 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of PCBD1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PCBD1 | 5092 | 203557_s_at | 0.0057 | 0.9951 | |
| GSE20347 | PCBD1 | 5092 | 203557_s_at | -0.1681 | 0.3519 | |
| GSE23400 | PCBD1 | 5092 | 203557_s_at | -0.3016 | 0.0000 | |
| GSE26886 | PCBD1 | 5092 | 203557_s_at | -0.5347 | 0.0756 | |
| GSE29001 | PCBD1 | 5092 | 203557_s_at | -0.2873 | 0.1319 | |
| GSE38129 | PCBD1 | 5092 | 203557_s_at | -0.1346 | 0.4675 | |
| GSE45670 | PCBD1 | 5092 | 203557_s_at | -0.2711 | 0.1174 | |
| GSE53622 | PCBD1 | 5092 | 62330 | -0.3462 | 0.0000 | |
| GSE53624 | PCBD1 | 5092 | 62330 | -0.2027 | 0.0002 | |
| GSE63941 | PCBD1 | 5092 | 203557_s_at | 2.5177 | 0.0003 | |
| GSE77861 | PCBD1 | 5092 | 203557_s_at | -0.4092 | 0.0957 | |
| GSE97050 | PCBD1 | 5092 | A_23_P367405 | -0.4391 | 0.2763 | |
| SRP007169 | PCBD1 | 5092 | RNAseq | -0.9677 | 0.0269 | |
| SRP008496 | PCBD1 | 5092 | RNAseq | -0.8452 | 0.0041 | |
| SRP064894 | PCBD1 | 5092 | RNAseq | -0.4455 | 0.1375 | |
| SRP133303 | PCBD1 | 5092 | RNAseq | -0.0699 | 0.7298 | |
| SRP159526 | PCBD1 | 5092 | RNAseq | -0.1724 | 0.6748 | |
| SRP193095 | PCBD1 | 5092 | RNAseq | -0.2422 | 0.1028 | |
| SRP219564 | PCBD1 | 5092 | RNAseq | -0.2963 | 0.5117 | |
| TCGA | PCBD1 | 5092 | RNAseq | -0.1111 | 0.0721 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by PCBD1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PCBD1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PCBD1 | 5092 | 2 | 4 | 24 | |
| GSE20123 | PCBD1 | 5092 | 2 | 3 | 25 | |
| GSE43470 | PCBD1 | 5092 | 1 | 7 | 35 | |
| GSE46452 | PCBD1 | 5092 | 0 | 11 | 48 | |
| GSE47630 | PCBD1 | 5092 | 2 | 14 | 24 | |
| GSE54993 | PCBD1 | 5092 | 7 | 0 | 63 | |
| GSE54994 | PCBD1 | 5092 | 2 | 11 | 40 | |
| GSE60625 | PCBD1 | 5092 | 0 | 0 | 11 | |
| GSE74703 | PCBD1 | 5092 | 1 | 4 | 31 | |
| GSE74704 | PCBD1 | 5092 | 1 | 1 | 18 | |
| TCGA | PCBD1 | 5092 | 10 | 24 | 62 |
Total number of gains: 28; Total number of losses: 79; Total Number of normals: 381.
Somatic mutations of PCBD1:
Generating mutation plots.
Highly correlated genes for PCBD1:
Showing top 20/143 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PCBD1 | TMEM125 | 0.69604 | 3 | 0 | 3 |
| PCBD1 | THBS4 | 0.683017 | 3 | 0 | 3 |
| PCBD1 | ADCK1 | 0.669427 | 3 | 0 | 3 |
| PCBD1 | YBX2 | 0.663694 | 3 | 0 | 3 |
| PCBD1 | CCDC88C | 0.659337 | 3 | 0 | 3 |
| PCBD1 | LINC00323 | 0.641691 | 3 | 0 | 3 |
| PCBD1 | DHPS | 0.640777 | 3 | 0 | 3 |
| PCBD1 | C2orf73 | 0.637318 | 3 | 0 | 3 |
| PCBD1 | TRIM26 | 0.636471 | 3 | 0 | 3 |
| PCBD1 | ERGIC3 | 0.630347 | 4 | 0 | 3 |
| PCBD1 | VRK3 | 0.626886 | 4 | 0 | 3 |
| PCBD1 | PCMT1 | 0.624691 | 3 | 0 | 3 |
| PCBD1 | TMEM219 | 0.623747 | 4 | 0 | 3 |
| PCBD1 | MOSPD3 | 0.618094 | 3 | 0 | 3 |
| PCBD1 | TOB1-AS1 | 0.617481 | 6 | 0 | 5 |
| PCBD1 | RSBN1 | 0.615152 | 5 | 0 | 3 |
| PCBD1 | SP1 | 0.610093 | 4 | 0 | 3 |
| PCBD1 | MBP | 0.608897 | 3 | 0 | 3 |
| PCBD1 | IBA57 | 0.606328 | 3 | 0 | 3 |
| PCBD1 | DISP1 | 0.606115 | 5 | 0 | 4 |
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