| Full name: dishevelled segment polarity protein 2 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 17p13.1 | ||
| Entrez ID: 1856 | HGNC ID: HGNC:3086 | Ensembl Gene: ENSG00000004975 | OMIM ID: 602151 |
| Drug and gene relationship at DGIdb | |||
DVL2 involved pathways:
Expression of DVL2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DVL2 | 1856 | 57532_at | 0.2664 | 0.3860 | |
| GSE20347 | DVL2 | 1856 | 57532_at | 0.6885 | 0.0000 | |
| GSE23400 | DVL2 | 1856 | 57532_at | 0.3492 | 0.0000 | |
| GSE26886 | DVL2 | 1856 | 57532_at | 1.1661 | 0.0000 | |
| GSE29001 | DVL2 | 1856 | 57532_at | 0.4933 | 0.0425 | |
| GSE38129 | DVL2 | 1856 | 57532_at | 0.5836 | 0.0000 | |
| GSE45670 | DVL2 | 1856 | 57532_at | 0.1024 | 0.6137 | |
| GSE63941 | DVL2 | 1856 | 57532_at | -0.1946 | 0.5736 | |
| GSE77861 | DVL2 | 1856 | 57532_at | 0.7311 | 0.0007 | |
| GSE97050 | DVL2 | 1856 | A_23_P55342 | -0.0290 | 0.9126 | |
| SRP007169 | DVL2 | 1856 | RNAseq | 0.2676 | 0.5282 | |
| SRP008496 | DVL2 | 1856 | RNAseq | 0.2445 | 0.3168 | |
| SRP064894 | DVL2 | 1856 | RNAseq | -0.0206 | 0.8764 | |
| SRP133303 | DVL2 | 1856 | RNAseq | 0.1697 | 0.2697 | |
| SRP159526 | DVL2 | 1856 | RNAseq | 0.5302 | 0.0023 | |
| SRP193095 | DVL2 | 1856 | RNAseq | 0.5575 | 0.0000 | |
| SRP219564 | DVL2 | 1856 | RNAseq | 0.1515 | 0.6385 | |
| TCGA | DVL2 | 1856 | RNAseq | 0.2778 | 0.0000 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by DVL2 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of DVL2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DVL2 | 1856 | 4 | 2 | 24 | |
| GSE20123 | DVL2 | 1856 | 4 | 3 | 23 | |
| GSE43470 | DVL2 | 1856 | 1 | 4 | 38 | |
| GSE46452 | DVL2 | 1856 | 34 | 1 | 24 | |
| GSE47630 | DVL2 | 1856 | 7 | 1 | 32 | |
| GSE54993 | DVL2 | 1856 | 4 | 3 | 63 | |
| GSE54994 | DVL2 | 1856 | 5 | 8 | 40 | |
| GSE60625 | DVL2 | 1856 | 4 | 0 | 7 | |
| GSE74703 | DVL2 | 1856 | 1 | 2 | 33 | |
| GSE74704 | DVL2 | 1856 | 2 | 1 | 17 | |
| TCGA | DVL2 | 1856 | 17 | 21 | 58 |
Total number of gains: 83; Total number of losses: 46; Total Number of normals: 359.
Somatic mutations of DVL2:
Generating mutation plots.
Highly correlated genes for DVL2:
Showing top 20/1090 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DVL2 | ALKBH6 | 0.818654 | 3 | 0 | 3 |
| DVL2 | PLBD2 | 0.785202 | 3 | 0 | 3 |
| DVL2 | STAT2 | 0.753489 | 3 | 0 | 3 |
| DVL2 | HOXC9 | 0.742325 | 3 | 0 | 3 |
| DVL2 | SLC41A1 | 0.733909 | 3 | 0 | 3 |
| DVL2 | NOP58 | 0.732422 | 4 | 0 | 3 |
| DVL2 | STIM2 | 0.726579 | 4 | 0 | 3 |
| DVL2 | WDR66 | 0.723832 | 3 | 0 | 3 |
| DVL2 | SPATA17 | 0.713845 | 3 | 0 | 3 |
| DVL2 | DNAJC2 | 0.711814 | 7 | 0 | 6 |
| DVL2 | TBX1 | 0.709532 | 3 | 0 | 3 |
| DVL2 | TAF1 | 0.708643 | 4 | 0 | 3 |
| DVL2 | UBAP2L | 0.707311 | 6 | 0 | 6 |
| DVL2 | PDE7A | 0.698649 | 3 | 0 | 3 |
| DVL2 | HEXB | 0.695555 | 3 | 0 | 3 |
| DVL2 | LRRC8D | 0.691199 | 6 | 0 | 6 |
| DVL2 | PLCG2 | 0.690442 | 3 | 0 | 3 |
| DVL2 | MSTO1 | 0.688761 | 4 | 0 | 3 |
| DVL2 | DLX6-AS1 | 0.688048 | 3 | 0 | 3 |
| DVL2 | HOXD8 | 0.687626 | 3 | 0 | 3 |
For details and further investigation, click here
